The effects of breathing and coughing exercises on respiratory parameters in COVID-19 patients
DOI:
https://doi.org/10.15584/ejcem.2026.1.12Keywords:
cough exercise, COVID-19, deep breathing, nursing care, pneumonia, TriflowAbstract
Introduction and aim. COVID-19 primarily affects the respiratory system, often resulting in pneumonia and dyspnea that may persist after recovery. This study aimed to evaluate the effect of deep breathing and coughing exercises using a Triflow device on respiratory parameters in patients with COVID-19 pneumonia.
Material and methods. This single-blinded randomized controlled study was conducted with 326 patients diagnosed with COVID-19 pneumonia. Participants were randomly assigned to an experimental group (n=163) or a control group (n=163). The experimental group performed exercises for 10 consecutive days. The control group received routine hospital care, which included routine nurse-led monitoring of vital signs, peripheral oxygen saturation (SpO₂) assessment, medical treatment per clinical guidelines, and supportive care, but no structured breathing-exercise education. Data were analyzed using descriptive statistics, ANOVA, chi-square, and post hoc tests.
Results. After 10 days of intervention, Dyspnea-12 scores decreased more markedly in the experimental group than in the control group (mean change −15 vs. −8 points; p<0.001). Arterial oxygen and SpO₂ levels also improved significantly in the experimental group compared to controls (p<0.001), while respiratory rate decreased to a greater extent (p<0.001). No adverse effects were observed.
Conclusion. Deep breathing and coughing exercises with the Trilow device significantly reduced the severity of dyspnea and improved oxygenation in COVID-19 pneumonia patients. These findings suggest that incorporating structured respiratory exercises into standard care may enhance clinical outcomes and support recovery in this population.
Supporting Agencies
This study was funded by a grant from the Bartin University Scientific Research Projects Unit (Grant No: 2021-FEN-A-016).Downloads
References
Special Expert Group for Control of the Epidemic of Novel Coronavirus Pneumonia of the Chinese Preventive Medicine Association. An update on the epidemiological characteristics of novel coronavirus pneumonia (COVID-19). Zhonghua Liu Xing Bing Xue Za Zhi. 2020;41(2):139-144. doi:10.3760/cma.j.issn.0254-6450.2020.02.002
Li Q, Guan X, Wu P, et al. Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia. N Engl J Med. 2020;382(13):1199-1207. doi:10.1056/NEJMoa2001316
Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395(10223):497-506. doi:10.1016/S0140-6736(20)30183-5
Wang D, Hu B, Hu C, et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. JAMA. 2020;323(11):1061-1069. doi:10.1001/jama.2020.1585
Prabawa IMY, Silakarma D, Manuaba IBAP, Widnyana M, Jeviana A. Chest therapy and breathing exercise in COVID-19 patient: A case report. Bali Medical Journal. 2021;10(2):495-498. doi:10.15562/bmj.v10i2.2403
Guan WJ, Ni ZY, Hu Y, et al. Clinical characteristics of 2019 novel coronavirus infection in China. medRxiv. 2020;1-30. doi:10.1101/2020.02.06.20020974
Gonzalez-Gerez JJ, Bernal-Utrera C, Anarte-Lazo E, Garcia-Vidal JA, Botella-Rico JM, Rodriguez-Blanco C. Therapeutic pulmonary telerehabilitation protocol for patients affected by COVID-19, confined to their homes: study protocol for a randomized controlled trial. Trials. 2020;21(1). doi:10.1186/s13063-020-04494-w
Lewis LK, Williams MT, Olds TS. The active cycle of breathing technique: A systematic review and meta-analysis. Respir Med. 2012;106(2):155-172. doi:10.1016/J.RMED.2011.10.014
Felten-Barentsz KM, van Oorsouw R, Klooster E, et al. Recommendations for hospital-based physical therapists managing patients with COVID-19. Phys Ther. 2020;100(9):1444-1457. doi:10.1093/ptj/pzaa114
Polastri M. Physiotherapy in hospitalised patients with COVID-19 Disease: what we know so far. Int J Ther Rehabil. 2020;27(3). doi:10.12968/ijtr.2020.0035
Sheikh S, Rostami A, Shahbazi A, et al. Clinical effectiveness of guided breathing exercises in reducing anxiety, stress, and depression in COVID-19 patients. Sci Rep. 2024;14(1):1-10. doi:10.1038/s41598-024-78162-3
Frutos-Reoyo EJ, Cantalapiedra-Puentes E, González-Rebollo AM. Rehabilitación domiciliaria en el paciente con COVID-19. Rehabilitacion. 2020;55(2):83. doi:10.1016/J.RH.2020.10.004
Sümbüloğlu K, Sümbüloğlu V. Biostatistics. 17th ed. Edited by Hatipoğlu T. Ankara: Hatiboğlu Yayınevi; 2016.
Yorke J, Moosavi SH, Shuldham C, Jones PW. Quantification of dyspnoea using descriptors: development and initial testing of the dyspnoea-12. Thorax. 2010;65(1):21. doi:10.1136/THX.2009.118521
Gök Metin Z, Helvacı A. Dispne-12 ölçeğinin Türkçe geçerlik ve güvenirlik çalışması. Hacettepe Univ Hemşirelik Fakültesi Derg. 2018;5(2):102-115. doi:10.31125/hunhemsire.454354
T.C. Ministry of Health. COVID-19 Adult treatment algorithm. Accessed May 6, 2025. https://covid19.saglik.gov.tr/TR-66328/eriskin-tedavi-algoritmasi.html.
Kader M, Hossain MA, Reddy V, Perera NKP, Rashid M. Effects of short-term breathing exercises on respiratory recovery in patients with COVID-19: A quasi-experimental study. BMC Sports Sci Med Rehabil. 2022;14(1):1-10. doi:10.1186/s13102-022-00451-z
Öner Cengiz H, Ayhan M, Güner R. Effect of deep breathing exercise with Triflo on dyspnoea, anxiety and quality of life in patients receiving COVID-19 treatment: A randomized controlled trial. J Clin Nurs. 2021;31(23):3439-3453. doi:10.1111/jocn.16171
Allali G, Marti C, Grosgurin O, Morélot-Panzini C, Similowski T, Adler D. Dyspnea: the vanished warning symptom of COVID-19 pneumonia. J Med Virol. 2020;92(11):2272-2273. doi:10.1002/jmv.26172
Zha L, Xu X, Wang D, Qiao G, Zhuang W, Huang S. Modified rehabilitation exercises for mild cases of COVID-19. Ann Cardiothorac Surg. 2020;9(5):3100-3106. doi:10.21037/apm-20-753
Abdullahi A. Safety and efficacy of chest physiotherapy in patients with COVID-19: A critical review. Front Med. 2020;7:1-6. doi:10.3389/fmed.2020.00454
Khan MA, Khan ZA, Charles M, et al. Cytokine storm and mucus hypersecretion in COVID-19: review of mechanisms. J Inflamm Res. 2021;14:175-189. doi:10.2147/JIR.S271292
Kumar SS, Binu A, Devan Aswathy R, Nath Lekshmi R. Mucus targeting as a plausible approach to improve lung function in COVID-19 patients. Med Hypotheses. 2021;156(110680):1-9. doi:10.1016/j.mehy.2021.110680
Mollerup A, Henriksen M, Larsen SC, et al. Effect of PEP flute self-care versus usual care in early COVID-19: non-drug, open-label, randomised controlled trial in a Danish community setting. BMJ. 2021;375:e066952. doi:10.1136/bmj-2021-066952
Li K, Wu J, Wu F, et al. The clinical and chest CT features associated with severe and critical COVID-19 pneumonia. Invest Radiol. 2020;55(6):327-331. doi: 10.1097/RLI.0000000000000672
Li X, Ma X. Acute respiratory failure in COVID-19: Is tt "Typical" ARDS? Crit Care. 2020;24(1):1-5. doi:10.1186/s13054-020-02911-9
Nouri-Vaskeh M, Sharifi A, Khalili N, Zand R, Sharifi A. Dyspneic and non-dyspneic (silent) hypoxemia in COVID-19: possible neurological mechanism. Clin Neurol Neurosurg. 2020;198:106217. doi:10.1016/j.clineuro.2020.106217
Pan F, Yang L, Li Y, et al. Factors associated with death outcome in patients with severe coronavirus disease-19 (COVID-19): A case-control study. Int J Med Sci. 2020;17(9):1281-1292. doi:10.7150/ijms.46614
Zheng QN, Xu MY, Zheng Y Le, Wang XY, Zhao H. Prediction of the rehabilitation duration and risk management for mild-moderate COVID-19. Disaster Med Public Health Prep. 2020;14(5):652-657. doi:10.1017/DMP.2020.214
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 European Journal of Clinical and Experimental Medicine

This work is licensed under a Creative Commons Attribution 4.0 International License.
Our open access policy is in accordance with the Budapest Open Access Initiative (BOAI) definition: this means that articles have free availability on the public Internet, permitting any users to read, download, copy, distribute, print, search, or link to the full texts of these articles, crawl them for indexing, pass them as data to software, or use them for any other lawful purpose, without financial, legal, or technical barriers other than those inseparable from having access to the Internet itself.
All articles are published with free open access under the CC-BY Creative Commons attribution license (the current version is CC-BY, version 4.0). If you submit your paper for publication by the Eur J Clin Exp Med, you agree to have the CC-BY license applied to your work. Under this Open Access license, you, as the author, agree that anyone may download and read the paper for free. In addition, the article may be reused and quoted provided that the original published version is cited. This facilitates freedom in re-use and also ensures that Eur J Clin Exp Med content can be mined without barriers for the research needs.




