Investigation of pharmaceuticals by nuclear magnetic resonance imaging and spectroscopy

Authors

  • Zuzanna Bober Center for Innovative Research in Medical and Natural Sciences, Faculty of Medicine, University of Rzeszow, Rzeszow, Poland https://orcid.org/0000-0002-7035-0677
  • David Aebisher Department of Human Immunology, Faculty of Medicine, University of Rzeszow, Rzeszow, Poland https://orcid.org/0000-0002-2661-6570
  • Jacek Tabarkiewicz Center for Innovative Research in Medical and Natural Sciences, Faculty of Medicine, University of Rzeszow, Rzeszow, Poland; Department of Human Immunology, Faculty of Medicine, University of Rzeszow, Rzeszow, Poland https://orcid.org/0000-0002-1264-2882
  • Wiesław Guz Center for Innovative Research in Medical and Natural Sciences, Faculty of Medicine, University of Rzeszow, Rzeszow, Poland; Department of Electroradiology, Faculty of Medicine, University of Rzeszow, Rzeszow, Poland https://orcid.org/0000-0002-1309-5374
  • Piotr Tutka Center for Innovative Research in Medical and Natural Sciences, Faculty of Medicine, University of Rzeszow, Rzeszow, Poland; Department of Experimental and Clinical Pharmacology, Faculty of Medicine, University of Rzeszow, Rzeszow, Poland https://orcid.org/0000-0002-8846-172X
  • Dorota Bartusik-Aebisher Department of Experimental and Clinical Pharmacology, Faculty of Medicine, University of Rzeszow, Rzeszow, Poland https://orcid.org/0000-0002-5557-5464

DOI:

https://doi.org/10.15584/ejcem.2017.2.2

Keywords:

drug delivery systems, drug forms, magnetic resonance imaging, pharmaceuticals

Abstract

Currently, new and easier ways of analyzing pharmaceutical drug forms and drug delivery mechanisms are being sought. Magnetic resonance imaging (MRI) is a non-invasive imaging technique that images drug forms such as tablets, liquids and topicals and drug form behavior in living organisms on both the tissue and cellular scale. The advantages of MRI include noninvasiveness, variable sample capacity and ease of transfer of phantom results to in vitro and in vivo studies. This review concerns the usefulness of clinical MRI that cannot be understated as this technique provides non-invasive and non-destructive insight into the properties of drug delivery systems. The research discussed here concerns the use of magnetic resonance, spectroscopy and chromatography to investigate selected pharmaceuticals and covers work of selecting drugs and antibodies for modification by synthesis for evaluation by MRI. Modifications have been aimed at improving therapeutic efficacy, delivery, and MRI. Modification conditions such as (pH, concentration, temperature, and the influence of other components present in the solutions) will be discussed to understand drug delivery system improvements and the reliability and repeatability of the results obtained. We hope to explore and expand the scope of pharmaceutical imaging with MRI for application in clinical medicine.

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References

Nebgen G, Gross D, Lehmann V, Muller F. 1H NMR microscopy of tablets. J Pharm Sci. 1995;84(3)283.

Hyde T, Gladden L, Payne R. A nuclear-magnetic-resonance imaging study of the effect of incorporating a macromolecular drug in poly(glycolicacid-co-DL-lactic acid). J Control Release. 1995;36(3)261-75.

Lee P, Adany P, Choi IY. Imaging based magnetic resonance spectroscopy (MRS) localization for quantitative neurochemical analysis and cerebral metabolism studies. Anal Biochem. 2017;529:40-47.

Cudalbu C, Cooper AJL. Editorial for the special issue on introduction to in vivo Magnetic Resonance Spectroscopy (MRS): A method to non-invasively study metabolism. Anal Biochem. 2017;529:1-3.

Capati A, Ijare OB, Bezabeh T. Diagnostic Applications of Nuclear Magnetic Resonance–Based Urinary Metabolomics. Magn Res Insights. 2017;10:1.

Gillinder L, Yi GS, Cowin G, et al. Quantification of intramyocardial metabolites by proton magnetic resonance spectroscopy. Front Cardiovasc Med. 2015;2:24.

Mandal P, Shukla D, Govind V, Boulard Y, Ersland L. Glutathione Conformations and Its Implications for in vivo Magnetic Resonance Spectroscopy. J Alzh Dis. 2017;10.3233/JAD-170350.

Zhang Y, An L, Shen J. Fast Computation of Full Density Matrix of Multispin Systems for Spatially Localized In Vivo Magnetic Resonance Spectroscopy. Med Phys J. 2017;10.1002/mp.12375.

Sheikh ASF, Mohamed M. Magnetic resonance spectroscopy and magnetic resonance spectroscopic imaging in Cerebral Autosomal-Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy: A literature review. J Pak Med Assoc. 2017;67(6):912-16.

Younisa S, Hougaarda A, Vestergaardb M, Larssonb H, Ashinaa M. Migraine and magnetic resonance spectroscopy: a systematic review. Curr Opin Neur J. 2017;30(3):246.

Guo L, Wang D, Bo G, Zhang H, Tao W, Shi Y. Early identification of hypoxic‑ischemic encephalopathy by combination of magnetic resonance (MR) imaging and proton MR spectroscopy. Exp Therap Med J. 2016;12:2835-42.

Bertholdo D, Watcharakorn A, Castillo M. Brain proton magnetic resonance spectroscopy: introduction and overview. Neuroimag Clin N Am. 2013;23(3):359-80.

Soares DP, Law M. Magnetic resonance spectroscopy of the brain: review of metabolites and clinical applications. Clin Radiol. 2009;64(1):12-21.

Pagani E, Bizzi A, Di Salle F, De Stefano N, Filippi M. Basic concepts of advanced MRI techniques. Neurol Sci. 2008;29,3:290-95.

Richardson JC, Bowtell R, Mäder K, Melia C. Pharmaceutical applications of magnetic resonance imaging (MRI). Adv Drug Deliv Rev. 2005;57,1191.

Figueiredo P, Lintinen K, Kiriazis A, et al. In vitro evaluation of biodegradable lignin-based nanoparticles for drug delivery and enhanced antiproliferation effect in cancer cells. Biomaterials. 2017;121:97-108.

Sua X, Chana C, Shia J, et al. A graphene quantum dot@Fe3O4@SiO2 based nanoprobe for drug delivery sensing and dual-modal fluorescence and MRI imaging in cancer cells. Biosens Bioelectron. 2017;92:489-95.

Feng Q, Zhang Y, Zhang W, et al. Programmed near-infrared light-responsive drug delivery system forcombined magnetic tumor-targeting magnetic resonance imaging and chemo-phototherapy. Acta Biomat. 2017;49:402-13.

Banoa S, Afzal M, Waraich M, Alamgire K, Nazir S. Paclitaxel loaded magnetic nanocomposites with folate modified chitosan/carboxymethyl surface; a vehicle for imaging and targeted drug delivery. Intern J Pharm. 2016;513:554-63.

Chen Y, Ai K, Liu J, Sun G, Yin Q, Lu L. Multifunctional envelope-type mesoporous silica nanoparticles for pH-responsive drug delivery and magnetic resonance imaging. Biomaterials. 2015;60:111-20.

Ma Y, Ge Y, Li L. Advancement of multifunctional hybrid nanogel systems: Construction and application in drug co-delivery and imaging technique. Mat Sci Eng. 2017;71:1281-92.

Raggi P, Baldassarre D, Day S, de Groot E, Fayad ZA. Non-invasive imaging of atherosclerosis regression with magnetic resonance to guide drug development. Atherosclerosis. 2016;251:476-82.

Lin B, Su H, Jin R, Li D, Wu C, Jiang X, Xia C, Gong Q, Song B, Ai H. Multifunctional dextran micelles as drug delivery carriers and magnetic resonance imaging probes. Sci Bull. 2015;60(14):1272.

Punčochová K, Ewing AV, Gajdošová M, et al. Identifying the mechanisms of drug release from amorphous solid dispersions using MRI and ATR-FTIR spectroscopic imaging. Intern J Pharm. 2015;483:256.

Um SY, Par JH, Chung MW, Choic KH, Lee HJ. 1H-Nuclear magnetic resonance-based metabolic profiling ofnonsteroidal anti-inflammatory drug-induced adverse effects in rats. J Pharm Biomed Anal. 2016;129:492-01.

Pacheco-Torres J, Mukherjee N, Walko M, et al. Image guided drug release from pH-sensitive Ion channel-functionalized stealth liposomes into an in vivo glioblastoma model. Nanomed: Nanotech Biol Med. 2015;11:1345-54.

Li L, Zhang R, Guo Y, et al. Functional magnetic porous silica for T1–T2 dual-modal magnetic resonance imaging and pH-responsive drug delivery of basic drugs. Nanotech. 2016;27(48):485702.

Gao N, Bozeman E, Qian W, et al. Tumor Penetrating Theranostic Nanoparticles for Enhancement of Targeted and Image-guided Drug Delivery into Peritoneal umors following Intraperitoneal Delivery. Theranostics. 2017;7(6):1689-94.

Melia CD, Rajabi-Siahboomi A, Bowtell R. Magnetic resonance imaging of controlled release pharmaceutical dosage forms. Pharm Sci & Techn Today. 1998;1,1:32-35.

Bowtell R, Sharp J, Peters A, et al. NMR microscopy of hydrating hydrophilic matrix pharmaceutical tablets. Magn Reson Imag. 1994;12(2):361-4.

Tung NT, Tran CS, Nguyen TL, Hoang T, Trinh TD, Nguyen TN. Formulation and biopharmaceutical evaluation of bitter taste masking microparticles containing azithromycin loaded in dispersible tablets. Eur J Pharm Biopharm 2017; doi: 10.1016/j.ejpb.2017.03.017

Fyfe CA, Blazek A. Investigation of hydrogel formation from hydroxypropylmethylcellulose (HPMC) by NMR spectroscopy and NMR imaging techniques. Macromolecules. 1997;30:6230.

Wang X, Roeloffs V, Kłosowski J, et al. Model-based T1 mapping with sparsity constraints using single-shot inversion-recovery radial FLASH. Magn Reson Med. 2017; DOI: 10.1002/mrm.26726.

Mazumdar A, Siegel MJ, Narra V, Luchtman-Jones L. Whole-Body Fast Inversion Recovery MR Imaging of Small Cell Neoplasms in Pediatric Patients: A Pilot Study. Am J Roentgen. 2002;179:1261-1266.

Gupta RK. A modified fast inversion-recovery technique for spin-lattice relaxation measurements. J Magn Reson. 1980;38(3):447-452.

Helms G, Hagberg GE. In vivo quantification of the bound pool T1 in human white matter using the binary spin–bath model of progressive magnetization transfer saturation. Phys Med & Biol. 2009;54:23-25.

Chow K, Flewitt JA, Green JD, Pagano JJ, Friedrich MG, Thompson RB. Saturation recovery single-shot acquisition (SASHA) for myocardial T1 mapping. Magn Reson Med. 2013;71(6):2082-95.

Deoni SCL, Peters TM, Rutt BK. Determination of optimal angles for variable nutation proton magnetic spin-lattice, T1, and spin-spin, T2, relaxation times measurement. Magn Reson Med. 2003;51(1):194-99.

Messroghli DR, Nordmeyer S, Dietrich T, et al. Assessment of Diffuse Myocardial Fibrosis in Rats Using Small-Animal Look-Locker Inversion Recovery T1 Mapping. Cardiovascr Imag. 2011;4:636-40.

Träber F, Block W, Lamerichs R, Gieseke J, Schild HH. 1H metabolite relaxation times at 3.0 tesla: Measurements of T1 and T2 values in normal brain and determination of regional differences in transverse relaxation. J Magn Reson Imag. 2004;19(5):537-45.

Mlynárik V, Gruber S, Moser E. Proton T1 and T2 relaxation times of human brain metabolites at 3 Tesla. NMR in Biomed. 2001;14(5):325-31.

Bouhrara M, Bonny JM. B₁ mapping with selective pulses. Magn Reson Med. 2012;68(5):1472-80.

Dai W, Garcia D, de Bazelaire C, Alsop DC. Continuous flow-driven inversion for arterial spin labeling using pulsed radio frequency and gradient fields. Magn Reson Med 2008;60(6):1488-97.

Gelman N, Ewing JR, Gorell JM, Spickler EM, Salomon EG. Interregional variation of longitudinal relaxation rates in human brain at 3.0 T: Relation to estimated iron and water contents. Magn Reson Med. 2001;45(1):71-79.

Kiessling F, Pichler BJ. Small Animal Imaging : Basics and Practical Guide. Springer Science & Business Media. 2010;150-55.

Shah B, Anderson SW, Scalera J, Jara H, Soto JA. Quantitative MR Imaging: Physical Principles and Sequence Design in Abdominal Imaging. RadioGraphics. 2010;31(3):867-80.

Huang J, Zhang M, Lu J, Cai C, Chen L, Cai S. A fast chemical exchange saturation transfer imaging scheme based on single-shot spatiotemporal encoding. Magn Reson Med. 2017;77(5):1786-96.

Bydder GM, Pennock JM, Steiner RE, Khenia S, Payne JA, Young IR. The short TI inversion recovery sequence--an approach to MR imaging of the abdomen. Magn Reson Imaging. 1985;3(3):251-54.

Kurland RJ. Strategies and tactics in NMR imaging relaxation time measurements. I. Minimizing relaxation time errors due to image noise--the ideal case. Magn Reson Med. 1985; 2(2):136-58.

Bydder GM, Pennock JM, Steiner RE, Khenia S, Payne JA, Young IR. The short TI inversion recovery sequence--an approach to MR imaging of the abdomen. Magn Reson Imaging. 1985;3(3):251-54.

Hardy CJ, Edelstein WA, Vatis D, Harms R, Adams WJ. Calculated T1 images derived from a partial saturation-inversion recovery pulse sequence with adiabatic fast passage. Magn Reson Imaging. 1985;3(2):107-16.

Pacheco-Torres J, Mukherjee N, Walko M, et al. Image guided drug release from pH-sensitive Ion channel-functionalized stealth liposomes into an in vivo glioblastoma model. Nanomedicine. 2015;11(6):1345-54.

Tayari N, Heerschap A, Scheenen TWJ, Kobus T. In vivo MR spectroscopic imaging of the prostate, from application to interpretation. Anal Biochem. 2017;529:158–70.

Al-Iedani O, Lechner-Scott J, Ribbons K, Ramadan S. Fast magnetic resonance spectroscopic imaging techniques in human brain- applications in multiple sclerosis. J Biomed Sci. 2017;24(1):17-20.

Thrippleton MJ, Parikh J, Harris BA, et al. Reliability of MRSI brain temperature mapping at 1.5 and 3 T. NMR in Biomedicine. 2013;27(2):183-90.

Kasten J, Lazeyras F, Van De Ville D. Data-driven MRSI spectral localization via low-rank component analysis. IEEE Trans Med Imaging. 2013;32(10):1853-63.

Fu Y, Serrai H. Fast magnetic resonance spectroscopic imaging (MRSI) using wavelet encoding and parallel imaging: in vitro results. J Magn Reson. 2011;211(1):45-51.

Madhu B, Hjartstam J, Soussi B. Studies of the internal flow process in polymers by H NMR microscopy at 500 MHz. J ControllRelease. 1998;56:95-04.

Hyde T, Gladden L. Simultaneous measurement of water and polymer concentration profiles during swelling of poly(ethylene oxide) using magnetic resonance imaging. Polymer. 1998;4:811-19.

Narasimhan B, Snaar J, Bowtell R, Morgan S, Melia C, Peppas N. Magnetic Resonance Imaging Analysis of Molecular Mobility during Dissolution of Poly(vinyl alcohol) in Water. Macromolecules. 1999;32(3):704–10.

Harding S, Baumann H, Gren T, Seo A. NMR microscopy of the uptake, distribution and mobility of dissolution media in small, sub-millimetre drug delivery systems. J Control Release. 2000;66(1):81–99.

Malveau C, Baille W, Zhu X, Marchessault R. NMR imaging of high-amylose starch tablets. 2. Effect of tablet size. Biomacromolecules. 2002;3(6):1249–54.

Johns M, Gladden L. Magnetic resonance studies of dissolving particulate solids. Magn Reson Imag. 2003;21(3–4):395–96.

Baumgartner S, Lahajnar G, Sepe A, Kristl J. Quantitative evaluation of polymer concentration profile during swelling of hydrophilic matrix tablets using 1H NMR and MRI methods. Eur J Pharm Biopharm. 2005;59(2):299–06.

Djemai A, Sinka I. NMR imaging of density distributions in tablets. Intern J Pharm. 2006;319;55–62.

Karakosta E, McDonald P. An MRI analysis of the dissolution of a soluble drug incorporated within an insoluble polymer tablet. Appl Magn Reson. 2007;32(1–2):75–91.

Therien-Aubin H, Zhu X, Ravenelle F, Marchessault R. Membrane formation and drug loading effects in high amylose starch tablets studied by NMR imaging. Biomacromolecules. 2008;9(4):1248–54.

Strübing S, Abboud T, Contri R, Metz H, Mäder K. New insights on poly(vinyl acetate)-based coated floating tablets: Characterisation of hydration and CO2 generation by benchtop MRI and its relation to drug release and floating strength. Eur. J. Pharm. Biopharm. 2008;69(2):708–17.

Haas A. Snapshot FLASH MRI. Applications to T1, T2 and Chemical-Shift Imaging. Magn Reson Med. 1990;13,77-89.

Keenan K, Stupic K, Boss M, et al. Multi-site, multi‐vendor comparison of T1 measurement using ISMRM/NIST system phantom. ISMRM 24th Annual Meeting. 2016;55:3290.

Yoshimura K, Kato H, Kuroda M, et al. Development of a Tissue-Equivalent MRI Phantom Using Carrageenan Gel. Magn Reson Med. 2003;50:1011–17.

Kato H, Kuroda M, Yoshimura K, et al. Composition of MRI phantom equivalent to human tissues. Am Assoc Phys Med. 2005; DOI: 10.1118/1.2047807.

Jensen M, Caruthers S, Jara H. Quantitative Magnetic Resonance Imaging With The Mixed Turbo Spin-echo Pulse Sequence: A Validation Study. The Internet J Radiol. 2000;2(1).

Morawski AM, Winter PM, Crowder KC, et al. Targeted nanoparticles for quantitative imaging of sparse molecular epitopes with MRI. Magn Reson Med. 2004;51(3):480-86.

Adriaensen H, Musse M, Quellec S, Vignaud A, Cambert M, Mariette F. MSE-MRI sequence optimisation for measurement of bi- and tri-exponential T2 relaxation in a phantom and fruit. Magn Reson Imag. 2013;31,1677–89.

Zeitler JA, Gladden LF. In-vitro tomography and non-destructive imaging at depth of pharmaceutical solid dosage forms. Eur J of Pharm Biopharm. 2009;71(1):2-22.

Nott KP. Magnetic resonance imaging of tablet dissolution. Eur J Pharm Biopharm 2010;74(1):78-83.

Lavdas I, Behan KC, Papadaki A, McRobbie DW, Aboagye EO. A phantom for diffusion-weighted MRI (DW-MRI). J Magn Reson Imag. 2013;38(1):173-79.

Pothayee N, Balasubramaniam S, Pothayee N, et al. Magnetic Nanoclusters with Hydrophilic Spacing for Dual Drug Delivery and Sensitive Magnetic Resonance Imaging. J Mater Chem B Mater Biol Med. 2013;1(8):1142–49.

Jain TK, Richey J, Strand M, Leslie-Pelecky DL, Flask C, Labhasetwar V. Magnetic Nanoparticles with Dual Functional Properties: Drug Delivery and Magn Reson Imag Biomater 2008;29(29):4012–21.

Singh A, Dilnawaz F, Mewar S, Sharma U, Jagannathan NR, Sahoo SK. Composite Polymeric Magnetic Nanoparticles for Co-Delivery of Hydrophobic and Hydrophilic Anticancer Drugs and MRI Imaging for Cancer Therapy. ACS Appl Mater Interfaces. 2011;3(3):842–56.

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Published

2017-06-30

How to Cite

Bober, Z., Aebisher, D., Tabarkiewicz, J., Guz, W., Tutka, P., & Bartusik-Aebisher, D. (2017). Investigation of pharmaceuticals by nuclear magnetic resonance imaging and spectroscopy. European Journal of Clinical and Experimental Medicine, 15(2), 99–108. https://doi.org/10.15584/ejcem.2017.2.2

Issue

Vol. 15 No. 2 (2017)

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REVIEW PAPERS

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