Macro and micronutrient deficiency in inflammatory bowel diseases
DOI:
https://doi.org/10.15584/ejcem.2017.4.7Keywords:
Crohn’s disease, IBD, ulcerative colitis, vitaminsAbstract
Introduction. Inflammatory bowel disease (IBD) is group of global range inflammatory conditions. There has been a regular increase in the number of IBD cases. Patients exclude whole food groups from their diet fearing the emergence of disease symptoms or due to learning from unreliable sources. Doing so, they might deepen the already existing vitamin deficiencies which occur along with the shortage of many minerals. These deficiencies might intensify the disease process or cause a new one. The most common deficits pointed out by numerous researchers concern vitamin D, calcium, cobalamin, folic acid and iron. It is well worth introducing selenium, zinc and ascorbic acid into a diet because of their immunomodulating effect. Important aspect of the healing process is a personalized diet which is designed to compensate for, or prevent vitamin and mineral deficiencies.
Aim. The purpose of the study was to review the literature about vitamin and mineral deficiency in Inflammatory Bowel Diseases.
Materials and method. Analysis of literature.
Downloads
References
Kaplan GG, Ng SC. Understanding and Preventing the Global Increase of Inflammatory Bowel Disease. Gastroenterology. 2017;152(2):313-321.
Matsuoka K, Kanai T. The gut microbiota and inflammatory bowel disease. Semin Immunopathol. 2015;37(1):47-55.
Hendrickson BA, Gokhale R, Cho JH. Clinical Aspects and Pathophysiology of Inflammatory Bowel Disease. Clin Microbiol Rev. 2002;15(1):79-94.
Limbergen J, Radford-Smith G, Satsangi J. Advances in IBD genetics. Nature Reviews Gastroenterology & Hepatology. 2014;11, 372–385.
Khor B, Gardet A, Xavier RJ. Genetics and pathogenesis of inflammatory bowel disease. Nature. 2011;15,474(7351):307–317.
Buttó LF, Haller D. Dysbiosis in Crohn's disease - Joint action of stochastic injuries and focal inflammation in the gut. Gut Microbes. 2017;8(1):53–58.
Ahmed I, Roy BC, Khan SA, Septer S, Umar S. Microbiome, Metabolome and Inflammatory Bowel Disease. Microorganisms. 2016;4(2):20.
Darfeuille-Michaud, Boudeau J, Bulois P, et al. High prevalence of adherent-invasive Escherichia coli associated with ileal mucosa in Crohn’s disease. Gastroenterology. 2004;127:412–421.
Manichanh C, Rigottier‐Gois L, Bonnaud E, et al. Reduced diversity of faecal microbiota in Crohn's disease revealed by a metagenomic approach. Gut. 2006;55(2): 205–211.
Bonaz BL, Bernstein ChN. Brain-Gut Interactions in Inflammatory Bowel Disease. Gastroenterology. 2013;144:36–49.
Ng V, Millard W, Lebrun C, Howard J. Low-intensity exercise improves quality of life in patients with Crohn's disease. Clin J Sport Med. 2007;17(5):384-388.
Ananthakrishnan AN. Epidemiology and risk factors for IBD. Nature Reviews Gastroenterology & Hepatology. 2014;12:205–217.
Packer N, Hoffman-Goetz L, Ward G. Does physical activity affect quality of life, disease symptoms and immune measures in patients with inflammatory bowel disease? A systematic review. J Sports Med Phys Fitness. 2010;50(1):1-18.
Ananthakrishnan AN, Khalili H, Konijeti GG, et al. Sleep duration affects risk for ulcerative colitis: a prospective cohort study. Clin Gastroenterol Hepatol. 2014;12(11):1879-1886.
Rapozo DC, Bernardazzi C, de Souza HSP. Diet and microbiota in inflammatory bowel disease: The gut in disharmony. World J Gastroenterol. 2017;28,23(12):2124–2140.
Barnes EL, Nestor M, Onyewadume L, De Silva P, Korzenik JR. High Dietary Intake of Specific Fatty Acids Increases Risk of Flares in Patients With Ulcerative Colitis in Remission During Treatment With Aminosalicylates. Clin Gastroenterol Hepatol. 2017;15(9):1390-1396.
Cheng L, Jin H, Qiang Y, et al. High fat diet exacerbates dextran sulfate sodium induced colitis through disturbing mucosal dendritic cell homeostasis. Int Immunopharmacol. 2016;40:1-10.
Costea I, Mack DR, Lemaitre RN, et al. Interactions between the dietary polyunsaturated fatty acid ratio and genetic factors determine susceptibility to pediatric Crohn's disease. Gastroenterology. 2014;146(4):929-931.
Chassaing B, Van de Wiele T, De Bodt J, Marzorati M, Gewirtz AT. Dietary emulsifiers directly alter human microbiota composition and gene expression ex vivo potentiating intestinal inflammation. Gut. 2017;66(8):1414-1427.
Ananthakrishnan AN, Khalili H, Gauree G, et al. A Prospective Study of Long-term Intake of Dietary Fiber and Risk of Crohn’s Disease and Ulcerative Colitis. Gastroenterology. 2013;145(5):970–977.
Czeczot H. Folic acid in physiology and pathology. Postepy Hig Med Dosw. 2008;62: 405-419.
Bartnik W. Wytyczne postępowania w nieswoistych chorobach zapalnych jelit. Przegl Gastroenterol. 2007;2(5):215-229.
Krzysik M, Biernat J, Grajeta H. The influence of Chosen Nutrients on Immune System Functioning Part II. Immunomodulatory Effects of Vitamins and Trace Elements on the Human Body. Adv Clin Exp Med. 2007;16,1:123–133.
Timms C, Forton DM, Poullis A. Social media use in patients with inflammatory bowel disease and chronic viral hepatitis. Clin Med (Lond). 2014;14(2):215.
Choi JM, Deen WK, Nguyen L, et al. The Value Of Social Media In Inflammatory Bowel Diseases. Journal of Crohn's and Colitis. 2014;8(1):201.
Vavricka SR, Rogler G. Intestinal absorption and vitamin levels: is a new focus needed? Dig Dis. 2012;30(3):73-80.
Cantorna MT, Mahon BD. Mounting evidence for vitamin D as an environmental factor affecting autoimmune disease prevalence. Exp Biol Med (Maywood). 2004;229(11):1136-1142.
Kuryłowicz A, Bednarczuk T, Nauman J. The influence of vitamin D deficiency on cancers and autoimmune diseases development. Endokrynol Pol. 2007;58(2):140-152.
Schulte C, Dignass AU, Mann K, Goebell H. Reduced bone mineral density and unbalanced bone metabolism in patients with inflammatory bowel disease. Inflamm Bowel Dis. 1998;4(4):268-275.
Bischoff SC, Herrmann A, Göke M, Manns MP, von zur Mühlen A, Brabant G. Altered bone metabolism in inflammatory bowel disease. Am J Gastroenterol. 1997;92(7):1157-1163.
Scott E, Gaywood I, Scott B. Guidelines for osteoporosis in coeliac disease and inflammatory bowel disease. Gut. 2000;46(1):11–18.
Holick MF. Vitamin D: importance in the prevention of cancers, type 1 diabetes, heart disease, and osteoporosis. Am J Clin Nutr. 2004;79(3):362-371.
Brash DE, Rudolph JA, Simon JA, et al. A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma. Proc Natl Acad Sci USA. 1991;15,88(22): 10124–10128.
Dymarska E, Grochowalska A, Krauss H. The influence of nutrition on immune system. Immunomodulation by fatty acids, vitamins, minerals and antioxidants. Nowiny Lek. 2013;82,3:222–231.
Hengstermann S, Valentini L, Schaper L, et al. Altered status of antioxidant vitamins and fatty acids in patients with inactive inflammatory bowel disease. Clin Nutr. 2008;27(4):571-578.
Levavasseur M, Becquart C, Pape E, et al. Severe scurvy: an underestimated disease. Eur J Clin Nutr. 2015;69(9):1076-1077.
Burr NE, Hull MA, Subramanian V. Folic Acid Supplementation May Reduce Colorectal Cancer Risk in Patients With Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis. J Clin Gastroenterol. 2017;51(3):247-253.
Lucendo AJ, Arias Á, Roncero Ó, et al. Anemia at the time of diagnosis of inflammatory bowel disease: Prevalence and associated factors in adolescent and adult patients. Dig Liver Dis. 2017;49(4):405-411.
Akpınar H, Çetiner M, Keshav S, Örmeci N, Törüner M. Diagnosis and treatment of iron deficiency anemia in patients with inflammatory Bowel disease and gastrointestinal bleeding: iron deficiency anemia working group consensus report. Turk J Gastroenterol. 2017;28(2):81-87.
Stein J, Hartmann F, Dignass AU. Diagnosis and management of iron deficiency anemia in patients with IBD. Nat Rev Gastroenterol Hepatol. 2010;7(11):599-610.
Bach U, Jensen HN, Rasmussen HH, Fallingborg J, Holst M. Dietary Habits in Patients with Ulcerative Colitis—Cause of Nutrient Deficiency? Food and Nutrition Sciences. 2014;5:1945-1950.
Hallberg L, Rossander L. Effect of different drinks on the absorption of non-heme iron from composite meals. Hum Nutr Appl Nutr. 1982;36(2):116-123.
Monsen ER. Iron nutrition and absorption: dietary factors which impact iron bioavailability. J Am Diet Assoc. 1988;88(7):786-790.
Bermejo F, Algaba A, Guerra I, et al. Should we monitor vitamin B12 and folate levels in Crohn's disease patients? Scand J Gastroenterol. 2013;48(11):1272-1277.
Headstrom PD, Rulyak SJ, Lee SD. Prevalence of and risk factors for vitamin B(12) deficiency in patients with Crohn's disease. Inflamm Bowel Dis. 2008;14(2):217-223.
Owczarek D, Rodacki T, Domagała-Rodacka R, Cibor D, Mach T. Diet and nutritional factors in inflammatory bowel diseases. World J Gastroenterol. 2016;21,22(3):895–905.
Weisshof R, Chermesh I. Micronutrient deficiencies in inflammatory bowel disease. Curr Opin Clin Nutr Metab Care. 2015;18(6):576-581.
Pan Y, Liu Y, Guo H, et al. Associations between Folate and Vitamin B12 Levels and Inflammatory Bowel Disease: A Meta-Analysis. Nutrients. 2017;9(4):382.
Pohl C, Hombach A, Kruis W. Chronic inflammatory bowel disease and cancer. Hepatogastroenterology. 2000;47(31):57-70.
Huang S, Ma J, Zhu M. Status of serum vitamin B12 and folate in patients with inflammatory bowel disease in China. Intest Res. 2017;15(1):103–108.
Leone S, Samhan-Arias A, Ben-Shachar I, et al. ECCO EFCCA Patient Guidelines on UC. Web site. https://www.ecco-ibd.eu/publications/ecco-efcca-patient-guidelines/uc-patient-guidelines/file/uc-patient-guidelines-in-polish.html?id=54. Published February, 2017.
Dudley M, Kojinkov M, Baraga D, et al. ECCO EFCCA Patient Guidelines on CD, 2017 Web site. https://www.ecco-ibd.eu/publications/ecco-efcca-patient-guidelines/cd-patient-guidelines/file/cd-patient-guidelines-in-polish.html?id=27. Published February, 2017.
Kornbluth A., Sachar DB. Ulcerative Colitis Practice Guidelines in Adults. American College of Gastroenterology, Practice Parameters Committee. Am J Gastroenterol. 2010;105(3):501-523. doi: 10.1038/ajg.2009.727.
Dignass A, Gasche C, Bettenworth D, et al. European Consensus on the Diagnosis and Management of Iron Deficiency and Anaemia in Inflammatory Bowel Diseases. J Crohns Colitis. 2015;9(3):211-222.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2017 European Journal of Clinical and Experimental Medicine
This work is licensed under a Creative Commons Attribution 4.0 International License.
Our open access policy is in accordance with the Budapest Open Access Initiative (BOAI) definition: this means that articles have free availability on the public Internet, permitting any users to read, download, copy, distribute, print, search, or link to the full texts of these articles, crawl them for indexing, pass them as data to software, or use them for any other lawful purpose, without financial, legal, or technical barriers other than those inseparable from having access to the Internet itself.
All articles are published with free open access under the CC-BY Creative Commons attribution license (the current version is CC-BY, version 4.0). If you submit your paper for publication by the Eur J Clin Exp Med, you agree to have the CC-BY license applied to your work. Under this Open Access license, you, as the author, agree that anyone may download and read the paper for free. In addition, the article may be reused and quoted provided that the original published version is cited. This facilitates freedom in re-use and also ensures that Eur J Clin Exp Med content can be mined without barriers for the research needs.
