The effect of diabetes on the connective tissue and the bone-joint system

Authors

DOI:

https://doi.org/10.15584/ejcem.2018.3.10

Keywords:

diabetes mellitus, diabetic osteopathy, limited joint mobility, joint disorders

Abstract

Introduction. Diabetes is associated with a number of complications, including renal disease, peripheral neuropathy, retinopathy, and vascular events.

Aim. Article presents the research results reported in the scientific literature about the influence of diabetes on connective tissue and the bone-joint system.

Material and methods. Analysis of literature.

Conclusion. Due to its multi-systemic nature, the development of additional manifestations, such as musculoskeletal complications, is possible including, for example diabetic osteopathy, limited joint mobility, joint disorders, and other, many of which are subclinical and correlated with the disease duration and its inadequate control. They should be recognized and treated properly, because their management improves the patients’ quality of life. 

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References

Otto-Buczkowska E. Diabetes mellitus influence on motor organs. Otto-Buczkowska E ed. Type 1 diabetes mellitus. Wrocław: Cornetis; 2006:369-376.

Merashli M, Chowdhury TA, Jawad AS. Musculoskeletal manifestations of diabetes mellitus. QJM. 2015;108:853-857.

Singla R, Gupta Y, Kalra S. Musculoskeletal effects of diabetes mellitus. J Pak Med Assoc. 2015;65:1024-1027.

Silva MB, Skare TL. Musculoskeletal disorders in diabetes mellitus. Rev Bras Reumatol. 2012;52:601-609.

Parada-Turska J, Majdan M. Motor system in diabetic patients. Post Hig. 2005;59: 236-244.

Fajardo RJ, Karim L, Calley VI, Bouxsein ML. A review of rodent models of type 2 diabetic skeletal fragility. J Bone Miner Res. 2014;29:1025-1040.

Sellmeyer DE, Civitelli R, Hofbauer LC, Khosla S, Lecka-Czernik B, Schwartz AV. Skeletal metabolism, fracture risk, and fracture outcomes in type 1 and type 2 diabetes. Diabetes. 2016;65:1757-1766.

Adami S. Bone health in diabetes: considerations for clinical management. Curr Med Res Opin. 2009;25:1057-1072.

Montagnani A, Gonnelli S, Alessandri M, Nuti R. Osteoporosis and risk of fracture in patients with diabetes: an update. Aging Clin Exp Res. 2011;23:84-90.

Dede AD, Tournis S, Dontas I, Trovas G. Type 2 diabetes mellitus and fracture risk. Metabolism. 2014;63:1480-1490.

Shanbhogue VV, Mitchell DM, Rosen CJ, Bouxsein ML. Type 2 diabetes and the skeleton: new insights into sweet bones. Lancet Diabetes Endocrinol. 2016;4:159-173.

Sellmeyer DE, Civitelli R, Hofbauer LC, Khosla S, Lecka-Czernik B, Schwartz AV. Skeletal metabolism, fracture risk, and fracture outcomes in type 1 and type 2 diabetes. Diabetes. 2016;65:1757-1766.

Ferrari S. Diabetes and Bone. Calcif Tissue Int. 2017;100:107-108.

Dhaliwal R, Cibula D, Ghosh C, Weinstock RS, Moses AM, Bone quality assessment in type 2 diabetes mellitus. Osteoporos Int. 2014;25:1969-1973.

Kim JH, Choi HJ, Ku EJ, et al. Trabecular bone score as an indicator for skeletal deterioration in diabetes. J Clin Endocrinol Metab. 2015;100:475-482.

Chobot AP, Haffke A, Polanska J, et al. Quantitative ultrasound bone measurements in pre-pubertal children with type 1 diabetes. Ultrasound Med Biol. 2012;38: 1109-1115.

Heilman K, Zilmer M, Zilmer K, Tillmann V. Lower bone mineral density in children with type 1 diabetes is associated with poor glycemic control and higher serum ICAM-1 and urinary isoprostane levels. J Bone Miner Metab. 2009;27:598-604.

Brandao FR, Vicente EJ, Daltro CH, Sacramento M, Moreira A, Adan L. Bone metabolism is linked to disease duration and metabolic control in type 1 diabetes mellitus. Diabetes Res Clin Pract. 2007;78:334-339.

Chobot AP, Haffke A, Polanska J, et al. Bone status in adolescents with type 1 diabetes. Diabetologia. 2010;53:1754-1760.

Valerio G, del Puente A, Esposito-del Puente A, Buono P, Mozzillo E, Franzese A. The lumbar bone mineral density is affected by long-term poor metabolic control in adolescents with type 1 diabetes mellitus. Horm Res. 2002;58:266-272.

Kanazawa I, Yamaguchi T, Yamamoto M, Yamauchi M, Yano S, Sugimoto T. Combination of obesity with hyperglycemia is a risk factor for the presence of vertebral fractures in type 2 diabetic men. Calcif Tissue Int. 2008;83:324-331.

Kanazawa I, Yamaguchi T, Sugimoto T. Serum insulin-like growth factor-I is a marker for assessing the severity of vertebral fractures in postmenopausal women with type 2 diabetes mellitus. Osteoporos Int. 2011;22:1191-1198.

Kanazawa I, Yamaguchi T, Yamamoto M, Yamauchi M, Yano S, Sugimoto T. Serum osteocalcin/bone-specific alkaline phosphatase ratio is a predictor for the presence of vertebral fractures in men with type 2 diabetes. Calcif Tissue Int. 2009;85:228-234.

Kanazawa I, Yamaguchi T, Sugimoto T. Baseline serum total adiponectin level is positively associated with changes in bone mineral density after 1-year treatment of type 2 diabetes mellitus. Metabolism. 2010;59:1252-1256.

Miazgowski T, Noworyta-Ziętara M, Safranow K, Ziemak J, Widecka K. Serum adiponectin, bone mineral density and bone turnover markers in post-menopausal women with newly diagnosed Type 2 diabetes: a 12-month follow-up. Diabet Med. 2012;29:62-69.

Hayakawa N, Suzuki A. Diabetes mellitus and osteoporosis. Effect of antidiabetic medicine on osteoporotic fracture. Clin Calcium. 2012;22:1383-1390.

McCarthy AD, Cortizo AM, Sedlinsky C. Metformin revisited: Does this regulator of AMP-activated protein kinase secondarily affect bone metabolism and prevent diabetic osteopathy. World J Diabetes. 2016;7:122-133.

Epstein S, Defeudis G, Manfrini S, Napoli N, Pozzilli P. Scientific Committee of the First International Symposium on Diabetes and Bone. Diabetes and disordered bone metabolism (diabetic osteodystrophy): time for recognition. Osteoporos Int. 2016;27:1931-1951.

Otto-Buczkowska E. Is LJM syndrome a problem in diabetic patients? Pol Med Rodz. 2004;6:1039-1041.

Monnier VM, Sell DR, Strauch C, et al. DCCT Research Group. The association between skin collagen glucosepane and past progression of microvascular and neuropathic complications in type 1 diabetes. J Diabetes Complications. 2013;27: 141-149.

Genuth S, Sun W, Cleary P, Gao X, Sell DR, Lachin J. DCCT/EDIC Research Group, Monnier VM. Skin advanced glycation end products glucosepane and methylglyoxal hydroimidazolone are independently associated with long-term microvascular complication progression of type 1 diabetes. Diabetes. 2015;64:266-278.

Abate M, Schiavone C, Pelotti P, Salini V. Limited joint mobility (LJM) in elderly subjects with type II diabetes mellitus. Arch Gerontol Geriatr. 2011;53:135-140.

Pandey A, Usman K, Reddy H, Gutch M, Jain N, Qidwai S. Prevalence of hand disorders in type 2 diabetes mellitus and its correlation with microvascular complications. Ann Med Health Sci Res. 2013;3:349–354.

Petrulewicz-Salamon I, Otto Buczkowska E. Limited joint mobility in diabetic patients. Part I. Med Metabol. 2005;9:52-60.

Petrulewicz-Salamon I. The influence of diabetes mellitus on joint mobility. Ortop Traumatol Rehabil. 2006;8:555-565.

Rosenbloom AL. Limited joint mobility in childhood diabetes: discovery, description, and decline. J Clin Endocrinol Metab. 2013;98:466-473.

Lindsay JR, Kennedy L, Atkinson AB, et al. Reduced prevalence of limited joint mobility in type 1 diabetes in a U.K. clinic population over a 20-year period. Diabetes Care. 2005;28:658-661.

Mustafa KN, Khader YS, Bsoul AK, Ajlouni K. Musculoskeletal disorders of the hand in type 2 diabetes mellitus: prevalence and its associated factors. Int J Rheum Dis. 2016;19:730-735.

Pandey A, Usman K, Reddy H, Gutch M, Jain N, Qidwai S. Prevalence of hand disorders in type 2 diabetes mellitus and its correlation with microvascular complications. Ann Med Health Sci Res. 2013;3:349-354.

Gerrits EG, Landman GW, Nijenhuis-Rosien L, Bilo HJ. Limited joint mobility syndrome in diabetes mellitus: A minireview. World J Diabetes. 2015;6:1108-1112.

Upreti V, Vasdev V, Dhull P, Patnaik SK. Prayer sign in diabetes mellitus. Indian J Endocrinol Metab. 2013;17:769–770.

Kamińska-Winciorek G, Jarosz-Chobot P, Otto-Buczkowska E. Cheiroartropatia – Limited Joint Mobility – early diabetic complication? Prz Dermatol. 2007;94:17-22.

Petrulewicz-Salamon I, Jarosz-Chobot P, Polańska J, Otto-Buczkowska E. LJM in diabetes mellitus: assessment of incidence and selected clinical risk factors. Diabetol Pol. 2006;13:115-116.

López-Martín I, Benito Ortiz L, Rodríguez-Borlado B, Cano Langreo M, García-Martínez FJ, Martín Rodríguez MF. Association between limited joint mobility syndrome and risk of accidental falls in diabetic patients. Semergen. 2015;41:70-75.

Walsh JS, Vilaca T. Obesity, Type 2 Diabetes and Bone in Adults. Calcif Tissue Int. 2017;100:528-535.

Bhat TA, Dhar SA, Dar TA, et al. The Musculoskeletal Manifestations of Type 2 Diabetes Mellitus in a Kashmiri Population. Int J Health Sci (Qassim). 2016;10: 57-68.

Al-Homood IA. Rheumatic conditions in patients with diabetes mellitus. Clin Rheumatol. 2013;32:527-533.

Serban AL, Udrea GF. Rheumatic manifestations in diabetic patients. J Med Life. 2012;5:252-257.

Burner TW, Rosenthal AK. Diabetes and rheumatic diseases. Curr Opin Rheumatol. 2009;21:50-54.

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Published

2018-09-30

How to Cite

Chwalba, A., & Otto-Buczkowska, E. (2018). The effect of diabetes on the connective tissue and the bone-joint system. European Journal of Clinical and Experimental Medicine, 16(3), 233–238. https://doi.org/10.15584/ejcem.2018.3.10

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