Nootropics: Phytochemicals with Neuroprotective and Neurocognitive Enhancing Properties
DOI:
https://doi.org/10.15584/ejcem.2019.3.9Keywords:
cognitive enhancers, phytochemicals, neurologic conditions, B vitamins, Hericium erinaceus, Ginkgo bilobaAbstract
Introduction. Neurological chronic conditions represent a healthcare concern worldwide. They hinder a person’s functionality affecting family, social interactions, as well as academic and work performance. In addition, the complexity of these illnesses and the variable response to treatments, as well as the side-effects, call for the research and implementation of phytochemicals known as Nootropics to form part of an integrative treatment.
Aim. To present the influence of nootropics on neuroprotection and neurocognition.
Material and methods. Analysis of literature data found in the PubMed database.
Results. Nootropics, which can be synthetic or natural, possess properties that translate in enhancement of mental or neurocognitive functions. Within the natural options, vitamins, plants and even fungi have been found to produce cognitive enhancement with less side-effects. Continuing research has shown promising therapeutic uses for B vitamins, Hericium herinaceus and Ginkgo biloba as coadjuvants in the treatment of neurologic chronic conditions to improve an individual’s neurocognitive functions and quality of life.
Conclusion. Nootropics open the door for new research, clinical implementation and promotion of integrative health especially in cognitive neuroscience by implementing products of natural sources. This is particularly important in order to identify side-effects, drug-herb interactions, proper posology and synergic actions that may prove to improve neurocognitive functioning and health improvement.
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References
Lanni C, Lenzken SC, Pascale A, et al. Cognition enhancers between treating and doping the mind. Pharmacol Res. 2008;57:196–213.
Hanumanthachar J, Charan CS, Majed AA. Antiamnesic and Neuroprotective Effects of Leaves of Mimusops Elengi on Brain Aging and Chemically Induced Amnesia in Mice. Biomed J Sci &Tech Res. 2018;4(2):1-5.
World Health Organization. Atlas: country resources for neurological disorders. 2nd ed. Geneva: World Health Organization; 2017:10-11.
Thongasa W, Tilokskulchai K, Chompoopong S, Tantisira MH. Effect of Centella asiatica on pathophysiology of mild chronic cerebral hypoperfusion in rats. Avicenna J Phytomed. 2018;8(3):210-226.
Steiner GZ, Mathersul DC, MacMillan F, et al. A systematic review of intervention studies examining nutritional and herbal therapies for mild cognitive impairment and Dementia using neuroimaging methods: Study characteristics and intervention efficacy. eCAM, 2017; 2017:1-21.
Sohlberg MM, Turkstra LS. Optimizing cognitive rehabilitation. Effective
Ovais M, Zia N, Ahmad I, et al. Phyto-Therapeutic and Nanomedicinal Approaches to Cure Alzheimer's Disease: Present Status and Future Opportunities. Aging Neurosci. 2018;10:284.
Alzheimer’s and Association. 2017 Alzheimer’s disease facts and figures. Alzheimers Dement. 2017;13:325–373. doi:10.1016/j.jalz.2017.02.001
Chiroma SM, Taib CNM, Moklas MAM, Baharuldin MTH, Amom Z, Jagadeesan S. The use of nootropics in Alzheimer’s disease: is there light at the end of the tunnel? Biomed. Res. Ther. 2019;6(1):2937-2944.
Trovato Salinaro A, Pennis, M, Di Paola R, et al. Neuroinflammation and neurohormesis in the pathogenesis of Alzheimer's disease and Alzheimer-linked pathologies: modulation by nutritional mushrooms. Immunity & ageing: I&A. 2018;15(8).
Cooper EL, Ma MJ. Alzheimer Disease: Clues from traditional and complementary medicine. J Tradit Complement Med. 2017;7(4):380–385.
Crespo-Bujosa HB, González MJ. Phytochemicals for the Treatment of Multiple Sclerosis? A Review of Scientific Evidence. J Orthomol Med. 2018;33(1).
Varo-Sánchez GM, Cuenca-López MD, Fernández-Fernández O, Jordan J. Dianas farmacológicas en la esclerosis múltiple. Rev Neurol. 2011;53(1): 27-34.
Huang WJ, Chen WW, Zhang X. Multiple sclerosis: Pathology, diagnosis and treatments. Exp Ther Med.2017;13(6):3163–3166.
Majdinasab N, Namjoyan F, Taghizadeh M, Saki H. The effect of evening primrose oil on fatigue and quality of life in patients with multiple sclerosis. Neuropsychiatr Dis Treat. 2018;14:1505–1512.
Gumus H, Akpinar Z, Yilmaz H. Effects of Multiple Sclerosis on Female Sexuality: A Controlled Study. J Sex Med. 2014;11:481–486.
Farzaei MH, Shahpiri Z, Bahramsoltani R, Nia MM, Najafi F, Rahimi R. Efficacy and tolerability of phytomedicines in Multiple Sclerosis Patients: A review. CNS Drugs. 2017;31:867–889.
Ghasemi N, Razavi S, Nikzad E. Multiple Sclerosis: Pathogenesis, Symptoms, Diagnoses and Cell-Based Therapy. Cell J. 2017;19(1):1–10.
Oyama MC, Louro ID. Multiple sclerosis. In. Chamberlin SL, & Narins B, eds. The gale encyclopedia of neurological disorders. Volume II. New York: Thompson/Gale; 2005: 561-565.
Thornton AE, De Freitas VG. The neuropsychology of multiple sclerosis. In. Grant I, & Adams KM, eds. Neuropsychological assessment of neuropsychiatric and neuromedical disorders. 3rd ed. New York: Oxford University Press; 2009:280-305.
Dobson R, Giovannon G. Multiple sclerosis – a review. Eur J Neurol. 2019;26:27–40.
Ramagopalan SV, Dobson R, Meie UC, Giovannoni G. Multiple sclerosis: risk factors, prodromes, and potential causal pathways. Lancet Neurol. 2010;9(7):727–739.
Crespo-Bujosa HB. Esclerosis Multiple. Retomando la vida. Manual de educación e intervención basada en la evidencia. USA; Createspace; 2014:23-25.
Cree B, Hollenbach JA, Bove R, et al. Silent progression in disease activity-free relapsing multiple sclerosis. Ann Neurol. 2019;85(5): 653–666. doi:10.1002/ana.25463
Fernández O, Tintoré M, Saiz A, et al. Revisión de las novedades del Congreso ECTRIMS 2017, presentadas en la X Reunión Post-ECTRIMS (II). Rev Neurol. 2018;67:50-62.
Kalász H, Ojh, S, Tekes K, et al. Pharmacognostical sources of popular medicine to treat Alzheimer’s Disease. Open Med Chem J. 2018;12:23-35.
Pranav J. A review on natural memory enhancers (nootropics). UJEAS. 2013;1(1):8-18.
Margineanu DG. A weird concept with unusual fate: Nootropic drug. Revue des Questions Scientifiques. 2011;182(1):33-52.
Jampilek J, Zaruba K, Oravec M, et al. Preparation of Silica Nanoparticles Loaded with Nootropics and Their In Vivo Permeation through Blood-Brain Barrier. BioMed Research International. 2015;2015.
Froestl W, Pfeifer A, Muhs A. Cognitive Enhancers (Nootropics). Part 1:
Froestl W, Pfeifer A, Muhs A. Cognitive Enhancers (Nootropics). Part 2: Drugs Interacting with Enzymes. JAD. 2013;33:547–658.
Froestl W, Pfeifer A, Muhs A. Cognitive Enhancers (Nootropics). Part 3: Drugs Interacting with Targets other than Receptors or Enzymes. Disease-modifying Drugs. JAD. 2013;34:1-114.
Froestl W, Muhs A, Pfeifer A. Cognitive Enhancers (Nootropics). Part 1: Drugs Interacting with Receptors. Update 2014. JAD. 2014;41:961–1019.
Froestl W, Muhs A, Pfeifer A. Cognitive Enhancers (Nootropics). Part 2: Drugs Interacting with Enzymes. Update 2014. JAD. 2014;42:1–68.
Froestl W, Pfeifer A, Muhs A. Cognitive Enhancers (Nootropics). Part 3: Drugs Interacting with Targets other than Receptors or Enzymes. Update 2014. Disease-modifying Drugs. JAD. 2014;42:1079–1149.
Suliman NA, Mat Taib CN, Mohd Moklas MA, Adenan MI., Hidayat Baharuldin MT, Basir R. Establishing Natural Nootropics: Recent Molecular Enhancement Influenced by Natural Nootropic. eCAM, 2016; 2016:4391375.
Sharadha S, Joel C, Prathyusha K, Krishnamohan G, Uma Maheswara Rao V. Evalution of nootropic and anti-nociceptive activity of green tea in comparison with Medha Rasayana. Chem Sci J. 2014;5:82.
Tabassum N, Rasool S, Malik ZA, Ahmad F. Natural Cognitive Enhancers. Journal of Pharmacy Research, 2012;5(1):153-160.
Kumar GP, Khanum F. Neuroprotective potential of phytochemicals. Pharmacogn Rev. 2012;6(12):81–90.
Kumar GP, Anilakumar KR, Naveen S. Phytochemicals having neuroprotective properties from dietary sources and medicinal herb. Pharmacognosy Journal, 2015;7(1): 1-17.
Schellack G, Harirari P, Schellack N. B-complex vitamin deficiency and supplementation. S Afr Pharm J., 2015;82(4):28-33.
Sesso HD. The truth about vitamins and minerals. Choosing the nutrients you need to stay healthy. Boston, USA: Harvard Health Publications. 2019.
Mozaffarian D. The truth about vitamins and minerals. Choosing the nutrients you need to stay healthy. Boston, USA: Harvard Health Publications. 2012.
Vigna L, Morelli F, Agnell, GM, et al. Hericium erinaceus Improves Mood and Sleep Disorders in Patients Affected by Overweight or Obesity: Could Circulating Pro-BDNF and BDNF Be Potential Biomarkers? eCAM, 2019;2019:7861297.
Spelman K, Sutherland E, Bagade A. Neurological Activity of Lion’s Mane (Hericium erinaceus). JRM. 2017;6:19-26.
Jiang S, Wang S, Sun Y, Zhang Q. Medicinal properties of Hericium erinaceus and its potential to formulate novel mushroom-based pharmaceuticals. Appl Microbiol Biotechnol. 2014;98:7661–7670.
Ratto D, Corana F, Mannucci B, et al. Hericium erinaceus Improves Recognition Memory and Induces Hippocampal and Cerebellar Neurogenesis in Frail Mice during Aging. Nutrients. 2019;11(4):715.
Brondino N, De Silvestri A, Re S, Lanati N, et al. A systematic review and meta-analysis of Ginkgo biloba in neuropsychiatric disorders: From ancient tradition to modern-day medicine. eCAM 2013; 1-11.
Gauthier S, & Schlaefke S. Efficacy and tolerability of Ginkgo biloba extract EGb 761 in dementia: a systematic review and meta-analysis of randomized placebo-controlled trials. Clin Interv Aging. 2017;9:2065-2077.
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