Atypical extra nasopharyngeal angiofibroma in an unusual location: tonsil posterior pillar (oropharynx)
DOI:
https://doi.org/10.15584/ejcem.2020.1.11Keywords:
atypical angiofibroma, extra nasopharyngeal (ENA), oropharynxAbstract
Introduction. Angiofibroma is a benign, locally aggressive highly vascular tumor that typically affects young adolescent males and has a pathognomonic epicenter of origin in the nasopharynx. The atypical angiofibromas share the same histological features as that of Juvenile nasopharyngeal angiofibroma, however they differ significantly in their clinical features.
Aim. Here we are reporting a very rare case of atypical angiofibroma in an adult male presenting as a non-vascular mass in the oropharynx with posterior pillar as the subsite.
Description of the case. A 26-years old male patient presented with chief complaints of foreign body sensation and mass in throat for one and a half months which was gradually progressive in size. Histopathological examination revealed a lesion with an intricate mixture of blood vessels, irregular fibrous stroma with loose edematous and fibrous area along with multinucleated stromal cells which was suggestive of angiofibroma.
Conclusion. Oropharyngeal angiofibroma, being an atypical angiofibroma in terms of site and presenting complaints, presents a diagnostic challenge. Though rare, it should always be kept as a differential diagnosis in any oropharyngeal mass irrespective of its vascularity, typical age or sex of the patient.
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Liu ZF, Wang DH, Sun XC, Wang JJ, Hu L, Dal PD. The site of origin and expansive routes of juvenile nasopharyngeal angiofibroma (JNA). Int. J Pediatr Otorhinolaryngol. 2011;75 (9):1088-92.
Celik B, Erisen L, Saraydaroglu O, Coskun H. Atypical angiofibromas: a report of four cases. Int J Pediatric Otorhinolaryngol. 2005;69:415-421.
Windfuhr JP, Vent J. Extra nasopharyngeal angiofibroma revisited. Clinical Otolaryngology. 2018;43:199-222.
Nomura K, Shimomura A, Awataguchi T, Murakami K, Kobayashi T. A case of angiofibroma originating from the inferior nasal turbinate. Auris Nasus Larynx. 2006; 33(2):191-193.
Perko M, Uehlinger E, Hjorting-Hansen E. Nasopharyngeal angiofibroma of the maxilla: report of case. J Oral Surg. 1969;27:645-648.
McDaniel RK, Glen D. Juvenile nasopharyngeal angiofibroma with lateral extension into the cheek: report of case. J Oral Maxillofac Surg. 1995;53:473-476.
Guo G, Paulino AFG. Lipomatous variant of nasopharyngeal angiofibroma: a case report. Arch Otolaryngol Head Neck Surg. 2002;128:448-450.
Rha KS, Byun SN, Kim TH, Kim YM. Bilateral juvenile nasopharyngeal angiofibroma. Otolaryngol Head Neck Surg. 2003;128:891-893.
Beeden AG, Alexander FW. An unusual pharyngeal tumor. J Laryngol Otol. 1971; 85: 733-735.
Gupta N, Dass A, Saini V, Anil Pol S, Mittal L. Extra nasopharyngeal Angiofibroma: A Diagnostic Dilemma. Philipp J Otolaryngol Head Neck Surg. 2018;33(1):39-42.
Eftekharian A, Samiei F, Rakhshan M. Angiofibroma with oropharyngeal origin. Pak J Med Sci. 2008;24:319-320.
Kim JK. A case of angiofibroma in the oropharynx. Korean J Otolaryngol.1972;15:69-72.
Ali S, Jones WI. Extranasopharyngeal angiofibromas. (Sex incidence and age distribution). J Laryngol Otol. 1982;96:559-565.
Chung YS, Kim JK, Kweon HW, Lee WS, Lee HH. Angiofibroma: an unusual presentation in soft palate. Korean J Otolaryngol.1995;38:779-785.
Cejas Mendez L, Espejo Castro E, Artazkoz del Toro JJ, Gil Curbelo JA, Saavedra de la Torre JA, de Miguel Hernandez B. Tonsillar angiofibroma. An Otorrinolaringol Ibero Am. 2000;27:605-611..
Mendoza-Ramıreza S, Martınez-Hernandeze J, Vicuna-Honoratob I, Mendoza-Ramırezd M, Murguıa-Pereza M. Angiofibroma atıpico dela amıgdala palatina. Rev Esp Patol. 2012;45:125-127.
Szymanska A, Szymanski M, Morshed K, Czekajska-Chehab E, Szczerbo-Trojanowska M. Extra nasopharyngeal angiofibroma: clinical and radiological presentation. Eur Arch Otorhinolaryngol. 2013;270:655-660.
Mehmet A, Orhan S, Supni M. Juvenile nasopharyngeal angiofibroma: Radiological Evaluation & preoperative Embolization. KBB Forum. 2006;5(1):58-61.
Makek MS, Andrews JC, Fisch U. Malignant transformation of a nasopharyngeal angiofibroma. Laryngoscope. 1989;99:1088-1092.
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