Simultaneous cardiac and cerebral infarction ‒ a case report
DOI:
https://doi.org/10.15584/ejcem.2026.1.24Keywords:
acute ischemic stroke, acute myocardial infarction, cardio-cerebral infarction, percutaneous coronary interventionAbstract
Introduction and aim. Concurrent cardiocerebral infarction (CCI) is a rare condition defined by the simultaneous presentation of acute myocardial infarction (AMI) and acute ischemic stroke (AIS). This case report aims to illustrate the clinical presentation, diagnostic challenges, and treatment considerations in a patient with CCI.
Description of the case. We describe the case of a 61-year-old Asian patient with symptoms of AMI, which was successfully treated with primary percutaneous coronary intervention (PCI). Six hours after the initial presentation, the patient developed symptoms of AIS. Imaging revealed an acute infarct in the left globus pallidus and small lacunar infarcts in the left thalamus region. Due to the location of the cerebral infarct, the patient was managed conservatively for AIS. The patient showed a positive response to the treatment, with no recurrence of chest pain or neurological symptoms observed at the six-month follow- up.
Conclusion. This case emphasizes the importance of prompt brain imaging to distinguish between different types of stroke and highlights the challenges in managing CCI, a condition linked to high mortality and morbidity. Early recognition and tailored therapy are crucial for improving prognosis.
Downloads
References
Habib M. Cardio-Cerebral infarction syndrome: definition, diagnosis, pathophysiology, and treatment. J Integr Cardiol. 2021;7. doi:10.15761/JIC.1000308
Lee J, Choi WY, Park GT, Park KT, Jeong HB, Won H. Concurrent Acute Ischemic Stroke and Myocardial Infarction Associated With Atrial Fibrillation. JACC Case Rep. 2024;29(1):102145. doi:10.1016/j.jaccas.2023.102145
Bao CH, Zhang C, Wang XM, Pan YB. Concurrent acute myocardial infarction and acute ischemic stroke: Case reports and literature review. Front Cardiovasc Med. 2022;9:1012345. doi:10.3389/fcvm.2022.1012345
Khairy M, Lu V, Ranasinghe N, Ranasinghe L. A case report on concurrent stroke and myocardial infarction. Asp Biomed Clin Case Rep. 2021;4(1):42-49. doi:10.36502/2021/ASJBCCR.6227
Bao CH, Zhang C, Wang XM, Pan YB. Concurrent acute myocardial infarction and acute ischemic stroke: Case reports and literature review. Front Cardiovasc Med. 2022;9:1012345. doi:10.3389/fcvm.2022.1012345
Yeo LLL, Andersson T, Yee KW, et al. Synchronous cardiocerebral infarction in the era of endovascular therapy: which to treat first?. J Thromb Thrombolysis. 2017;44(1):104-111. doi:10.1007/s11239-017-1484-2
Habib M. Cardio-Cerebral Infarction Syndrome: An overview. Int J Clin Case Rep Rev. 2021;8(1). doi:10.31579/2690-4861/140
Merkler AE, Diaz I, Wu X, et al. Duration of Heightened Ischemic Stroke Risk After Acute Myocardial Infarction. J Am Heart Assoc. 2018;7(22):e010782. doi:10.1161/JAHA.118.010782
Hachet O, Guenancia C, Stamboul K, et al. Frequency and predictors of stroke after acute myocardial infarction: specific aspects of in-hospital and postdischarge events. Stroke. 2014;45(12):3514-3520. doi:10.1161/STROKEAHA.114.006707
Chin PL, Kaminski J, Rout M. Myocardial infarction coincident with cerebrovascular accidents in the elderly. Age Ageing. 1977;6(1):29-37. doi:10.1093/ageing/6.1.29
Habib M, Alhout S. Concurrent cardio-cerebral infarction: Meta-analysis. Mathews J Case Rep. 2023;8(2):87. doi:10.30654/MJCR.10087
Lichtman JH, Krumholz HM, Wang Y, Radford MJ, Brass LM. Risk and predictors of stroke after myocardial infarction among the elderly: results from the Cooperative Cardiovascular Project. Circulation. 2002;105(9):1082-1087. doi:10.1161/hc0902.104708
Chiang CH, Hung WT, Huang WC, et al. The risk of stroke after acute myocardial infarction in patients with and without atrial fibrillation: A nationwide cohort study. J Chin Med Assoc. 2021;84(12):1126-1134. doi:10.1097/JCMA.0000000000000631
Abdi IA, Karataş M, Abdi AE, Hassan MS, Yusuf Mohamud MF. Simultaneous acute cardio- cerebral infarction associated with isolated left ventricle non-compaction cardiomyopathy. Ann Med Surg (Lond). 2022;80:104172. doi:10.1016/j.amsu.2022.104172
Powers WJ, Rabinstein AA, Ackerson T, et al. 2018 Guidelines for the Early Management of Patients With Acute Ischemic Stroke: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association. Stroke. 2018;49(3):e46-e110. doi:10.1161/STR.0000000000000158
Akinseye OA, Shahreyar M, Heckle MR, Khouzam RN. Simultaneous acute cardio-cerebral infarction: is there a consensus for management?. Ann Transl Med. 2018;6(1):7. doi:10.21037/atm.2017.11.06
Powers WJ, Rabinstein AA, Ackerson T, et al. Guidelines for the Early Management of Patients With Acute Ischemic Stroke: 2019 Update to the 2018 Guidelines for the Early Management of Acute Ischemic Stroke: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association. Stroke. 2019;50(12):e344-e418. doi:10.1161/STR.0000000000000211
Berge E, Whiteley W, Audebert H, et al. European Stroke Organisation (ESO) guidelines on intravenous thrombolysis for acute ischaemic stroke. Eur Stroke J. 2021;6(1):I-LXII. doi:10.1177/2396987321989865
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 European Journal of Clinical and Experimental Medicine

This work is licensed under a Creative Commons Attribution 4.0 International License.
Our open access policy is in accordance with the Budapest Open Access Initiative (BOAI) definition: this means that articles have free availability on the public Internet, permitting any users to read, download, copy, distribute, print, search, or link to the full texts of these articles, crawl them for indexing, pass them as data to software, or use them for any other lawful purpose, without financial, legal, or technical barriers other than those inseparable from having access to the Internet itself.
All articles are published with free open access under the CC-BY Creative Commons attribution license (the current version is CC-BY, version 4.0). If you submit your paper for publication by the Eur J Clin Exp Med, you agree to have the CC-BY license applied to your work. Under this Open Access license, you, as the author, agree that anyone may download and read the paper for free. In addition, the article may be reused and quoted provided that the original published version is cited. This facilitates freedom in re-use and also ensures that Eur J Clin Exp Med content can be mined without barriers for the research needs.




