Prevalence, prescription patterns, and quality of life of anaemia in adults with chronic renal disease
DOI:
https://doi.org/10.15584/ejcem.2023.4.20Keywords:
anaemia, chronic kidney disease, prescribing pattern, quality of lifeAbstract
Introduction and aim. Anaemia is a chronic kidney disease (CKD) condition characterised by a decline in glomerular filtration rate (GFR) and impaired kidney function. The aim of this study was to assess the prevalence, prescribing patterns, and quality of life of anaemia in patients with chronic renal disease who were adults (>18 years of age) at a tertiary care hospital.
Material and methods. Data on demographic characteristics, laboratory results, medication prescriptions, and quality of life assessments were collected. Statistical tests were performed to determine associations between anaemia prevalence and factors like age, gender, and CKD stage. The study included 132 patients, with a gender distribution of 89 men and 43 women.
Results. The most frequently prescribed drugs are epoetin (15.06%), multivitamins (14.82%), iron (10.65%), folic acid (10.22%), calcium carbonate (8.17%), calcitriol (5.6%), and omeprazole (4.22%). The cardiovascular system, blood disorders, and blood-producing organs come after the gastrointestinal tract and metabolism in the first anatomical level of the ATC classification.
Conclusion. It suggests hospital audits and recommendations for improved prescription practices. Further investigation into anaemia causes and drug class appropriateness is needed, and implementing improvements could potentially improve health outcomes.
Supporting Agencies
The author, Dr. Shanmugam Anandakumar, would like to thank the Indian Council of Medical Research (ICMR) for his ICMR Research Associate (RA) Scheme (Project ID: 2021: 9012; No: BMI/11(16)/2022).Downloads
References
Kwon HY, Kim E, You KH. Health-Related Quality of Life for Patients with Chronic Obstructive Pulmonary Disease in South Korea. Val in Heal. 2014;17:A780. doi: 10.1016/j.jval.2014.08.370
Hussien H, Apetrii M, Covic A. Health-related quality of life in patients with chronic kidney disease. Exp Rev of Pharm & Outcome Res. 2020;21:43-54. doi: 10.1080/14737167.2021.1854091
Ahmed R, Ahmed T, Ud Din N, et al. Health Related Quality of Life Among Chronic Kidney Disease Patients Undergoing Hemodialysis in Pakistan. Pak J Kidney Dis. 2021;5:100-104. doi: 10.53778/pjkd54182
Kim S-H, Oh YM, Jo M-W. Health-related quality of life in chronic obstructive pulmonary disease patients in Korea. Health Qual Life Outcomes. 2014;12:57. doi: 10.1186/1477-7525-12-57
Malik M, Nisha IU, Hussain A. Assessment of Health Related Quality of Life among Chronic Kidney Disease Patients: Challenges for Nephrologists in Pakistan. Journal of Advances in Medical and Pharmaceutical Sciences. 2020:22(11);42-48. doi: 10.9734/jamps/2020/v22i1130204
Lee SJ, Son H. Comparison of health-related quality of life between patients with stage 3 and 4 chronic kidney disease and patients undergoing continuous ambulatory peritoneal dialysis. Jpn J Nurs Sci. 2015;13:166-173. doi: 10.1111/jjns.12101
Akca N, Saygili M, Ture AK. The relationship between the perception of chronic disease care and health-related quality of life in adults with chronic kidney disease. Chronic Illn. 2021;18:874-888. doi: 10.1177/17423953211039792
Zhang Y, Li J, Yang L. Health-related quality of life of Chinese patients with chronic kidney disease: a study based on four EQ-5D-3L value sets. Sci Rep. 2023;13:7863. doi: 10.1038/s41598-023-35002-0
Taptagaporn S, Mongkolsomlit S, Rakkapao N, Kaewdok T, Wattanasoei S. Quality of Life among Patients Suffering from Chronic Kidney Disease in Chronic Kidney Disease Clinic of Thailand. The Open Public Health Journal. 2021;14:417-424. doi: 10.2174/1874944502114010417
Johnston S. Prescribing in patients with chronic kidney disease. Nurse Prescribing. 2017;15:192-197. doi: 10.12968/npre.2017.15.4.192
Al-Rajhi W, Al Salmi I. Quality of life and health related quality of life among end-stage kidney disease patients: Methodology. Journal of Nephrology & Renal Therapy 2021;21. 10.24966/NRT-7313/100039
Bashar MA, Haque ME, Islam MZ. Nutritional Status and Health Related Quality of Life Of Chronic Kidney Disease Patients. JOPSOM. 2022;40:44-51. doi: 10.3329/jopsom.v40i2.61796
Horvat N, Locatelli I, Kos M, Janežič A. Medication adherence and health-related quality of life among patients with chronic obstructive pulmonary disease. Acta Pharmaceutica 2018;68:117–125. https://doi.org/10.2478/acph-2018-0006.
McAdams-DeMarco MA, Ying H, Olorundare I, et al. Frailty and Health-Related Quality of Life in End Stage Renal Disease Patients of All Ages. J Frailty Aging. 2016;5(3):174-179.
Unruh ML, Hess R. Assessment of Health-Related Quality of Life Among Patients With Chronic Kidney Disease. Adv Chronic Kidney Dis. 2007;14:345-352. doi: 10.1053/j.ackd.2007.07.011
Parekh AJ. Systematic Review on Quality of Life of Patients with Chronic Kidney Disease. Inter J Psych Rehab. 2020;24:7432-7444. doi: 10.37200/ijpr/v24i5/pr2020777
Chen L, Wang J, Huang X, et al. Association between diabetes mellitus and health-related quality of life among patients with chronic kidney disease: results from the Chinese Cohort Study of Chronic Kidney Disease (C-STRIDE). Health Qual Life Outcomes. 2020;18. doi: 10.1186/s12955-020-01519-5
Aly A, Kharshid A, Syed Sulaiman S. Evaluation of Health-Related Quality of Life among Malaysian non Dialysis dependent Chronic Kidney Disease Patients. Value in Health. 2017;20: A896-A897. doi: 10.1016/j.jval.2017.08.2736
Jyotsna B. A Descriptive Analysis of Prescribing Patterns of Drugs in Chronic Kidney Disease Patients on Maintenance Hemodialysis. JMSCR. 2019;7:126. doi: 10.18535/jmscr/v7i5.126
Alrajhi W. SAT-220 Quality Of Life and Health Related Quality of Life in Patients with End Stage Kidney Disease. Kidney Int Rep. 2020;5:94. doi: 10.1016/j.ekir.2020.02.235
Krishnan A, Lim W, Teixeira-Pinto A, Craig J, Wong G. SUN-098 Health Related Quality Of Life In Patients With Chronic Kidney Disease. Kidney Int Rep. 2019;4:197. doi: 10.1016/j.ekir.2019.05.495
Andayani T, Puspitasari C. The Association Hemoglobin Levels with Health-Related Quality of Life of Patients with Chronic Kidney Disease. Value in Health. 2017;20:A492. doi: 10.1016/j.jval.2017.08.3026
Senanayake S, Gunawardena N, Palihawadana P, et al. Health related quality of life in chronic kidney disease; a descriptive study in a rural Sri Lankan community affected by chronic kidney disease. Health Qual Life Outcomes. 2020;18(1):106. doi: 10.1186/s12955-020-01369-1
Morga A, Alexandre AF, Koochaki P, Georgiadis A, Desvignes-Gleizes C. MO555 Assessment of Health-Related Quality of Life (Hrqol) Measures for Paediatric Patients with Anaemia of Chronic Kidney Disease (CKD). Nephrology Dialysis Transplantation. 2021;36:gfab085.0018. doi: 10.1093/ndt/gfab085.0018
Finkelstein FO, Finkelstein SH. The Impact of Anemia Treatment on Health-Related Quality of Life in Patients with Chronic Kidney Disease in the Contemporary Era. Adv Chronic Kidney Dis. 2019;26:250-252. doi: 10.1053/j.ackd.2019.04.003
Hsu Y-C, Lee P-H, Lei C-C, Shih Y-H, Lin C-L. Analgesic use, parents’ clan, and coffee intake are three independent risk factors of chronic kidney disease in middle and elderly-aged population: a community-based study. Renal Fail. 2014;36:361-366. doi: 10.3109/0886022x.2013.866017
Moon J. Perfluoroalkyl substances (PFASs) exposure and kidney damage: Causal interpretation using the US 2003–2018 National Health and Nutrition Examination Survey (NHANES) datasets. Environ Poll. 2021;288:117707. doi: 10.1016/j.envpol.2021.117707
Rao MV, Qiu Y, Wang C, Bakris G. Hypertension and CKD: Kidney Early Evaluation Program (KEEP) and National Health and Nutrition Examination Survey (NHANES), 1999-2004. Am J Kidney Dis. 2008; 51: 30–37. doi: 10.1053/j.ajkd.2007.12.012
Fehr T, Ammann P, Garzoni D, et al. Interpretation of erythropoietin levels in patients with various degrees of renal insufficiency and anemia. Kidney Inter. 2004; 66:1206-1211. doi: 10.1111/j.1523-1755.2004.00880.x
Al Salmi I. Quality of Life and Health-Related Quality of Life among end-stage Kidney Disease Patients: Testing the concepts and assessing the Measures. Nep Ren Therap. 2020;6:1-24. doi: 10.24966/nrt-7313/100041
Fidan C, Ağırbaş İ. The Effect of Renal Replacement Therapy on Quality of Life in Chronic Renal Failure: A Meta-Analysis. Clin Exp Nephrol. 2023;27(10):829-846. doi: 10.1007/s10157-023-02377-3
Han T-C, Lin H-S, Chen C-M. Association between Chronic Disease Self-Management, Health Status, and Quality of Life in Older Taiwanese Adults with Chronic Illnesses. Health. 2022;10:609. doi: 10.3390/healthcare10040609
Barile JP, Thompson WW, Zack MM, Krahn GL, Horner-Johnson W, Bowen SE. Multiple Chronic Medical Conditions and Health-Related Quality of Life in Older Adults, 2004–2006. Prev Chronic Dis. 2013;10:E162. doi: 10.5888/pcd10.120282
Bennett L. Patient independence in chronic kidney disease and anaemia: implications of the 2012 kdigo guideline. J Ren Care. 2013;39:108-117. doi: 10.1111/j.1755-6686.2013.12010.x
Chamney M, Pugh-Clarke K, Kafkia T, Wittwer I. CE: Continuing Education Article Management of anaemia in chronic kidney disease. J Ren Care. 2010;36:102-111. doi: 10.1111/j.1755-6686.2010.00149.x
Jenkins K. Measuring quality of life in anaemia management. J Renal Nurs. 2012;4:26-27. doi: 10.12968/jorn.2012.4.1.26
D’Souza MS, Rathinasamy EL. Education and Exercise on the Quality of Life among Adults with Chronic Renal Disease. Endocrinology and Disorders. 2018;2:1-7. doi: 10.31579/2640-1045/037
Stevens PE. Anaemia, diabetes and chronic kidney disease: where are we now. J Ren Care. 2012;38:67-77. doi: 10.1111/j.1755-6686.2012.00281.x
Wittwer I. Iron deficiency anaemia in chronic kidney disease. J Ren Care. 2013;39:182-188. doi: 10.1111/j.1755-6686.2013.12026.x
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