Assessment of serum creatinine, urea, and aminotransferase levels among methamphetamine addicted individuals in Khartoum State

Authors

  • Al-Noor Opied Al-Tayeb Chemical Pathology Department, Faculty of Medical Laboratory Science, University of Medical Sciences and Technology, Khartoum, Sudan
  • Mohammed Hayati Abubakr Chemical Pathology Department, Faculty of Medical Laboratory Science, University of Medical Sciences and Technology, Khartoum, Sudan
  • Hafsa Ahmed Elrheima Chemical Pathology Department, Faculty of Medical Laboratory Science, University of Medical Sciences and Technology, Khartoum, Sudan https://orcid.org/0000-0003-3255-4529
  • Ahmed Khalid Habbani Histopathology and Cytology Department, Faculty of Medical Laboratory Science, University of Medical Sciences and Technology, Khartoum, Sudan
  • Rami Y. Hassab Elrasul Biostatistics, Faculty of Medical Laboratory Science, Nepta College, Khartoum, Sudan

DOI:

https://doi.org/10.15584/ejcem.2024.1.10

Keywords:

aminotransferases, creatinine, methamphetamine, urea

Abstract

Introduction and aim. Methamphetamine-use disorder is a pressing global public health issue. In Sudan, the escalating meth amphetamine (METH) consumption has become a significant social and health problem. This study aims to evaluate liver and kidney biomarkers in methamphetamine addicts in Khartoum state

Material and methods. The study was an analytical prospective cross-sectional hospital-based study. One hundred partici pants were enrolled in this study, fifty were cases (methamphetamine addicts), and others were healthy non-METH users as a comparative group.

Results. METH users had a mean age of (27±7) years and had been using METH for an average of (14±9) months. Urea and cre atinine levels were also significantly elevated in METH users compared to non-users, with p<0.001 and p=0.044, respectively. Their aspartate transaminase (AST) and alanine transaminase (ALT) levels were significantly higher compared to non-users, with p<0.001.

Conclusion. There was significant increases in creatinine, urea, and aminotransferases levels in the case group. ALT showed a moderate positive correlation with abuse duration, while AST showed no significant correlation. Urea and creatinine levels had strong and moderate positive correlations with abuse duration, respectively.

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References

Zhang Y, Shu G, Bai Y, Chao J, Chen X, Yao H. Effect of methamphetamine on the fasting blood glucose in methamphetamine abusers. Metab Brain Dis. 2018;33(5):1585-1597. doi: 10.1007/s11011-018-0265-8

Shiao Y, Chen Y, Yeh Y, Huang T. Positive Effects of Laser Acupuncture in Methamphetamine Users Undergoing Group Cognitive Behavioral Therapy: A Pilot Study. Evid Based Complement Alternat Med. 2021;2021:1-8. doi: 10.1155/2021/5514873

Bishop ML, Fody EP, Shoeff LE. Principle, Techniques, Correlations. Eight edition. Lippincott William & Wilkins. Philadelphia. 2018;798-803.

Halpin LE, Yamamoto BK. Peripheral ammonia as a mediator of methamphetamine neurotoxicity. J Neurosci. 2012;32(38):13155-13163. doi: 10.1523/JNEUROSCI.2530-12.2012

Isoardi K, Mudge D, Harris K, Dimeski G, Buckley N. Methamphetamine intoxication and acute kidney injury: A prospective observational case series. Nephrology. 2020;25(10):758-764. doi: 10.1111/nep.13762

Isoardi K, Ayles S, Harris K, Finch C, Page C. Methamphetamine presentations to an emergency department. Emerg Med Australas. 2018;31(4):593-599. doi: 10.1111/1742-6723.13219

Ozer J, Ratner M, Shaw M, Bailey W, Schomaker S. The current state of serum biomarkers of hepatotoxicity. Toxicology. 2008;245:194-205. doi: 10.1016/j.tox.2007.11.021

Kuo CJ, Tsai SY, Liao YT, et al. Elevated aspartate and alanine aminotransferase levels and natural death among patients with methamphetamine dependence. PloS One. 2012;7(1):e29325. doi: 10.1371/journal.pone.0029325

Basile D, Anderson M, Sutton T. Pathophysiology of Acute Kidney Injury. Compr Physiol. 2012;1303-1353. doi: 10.1002/cphy.c110041

Baradhi K, Pathireddy S, Bose S, Aeddula N. Methamphetamine (N-methylamphetamine)-induced renal disease: under evaluated cause of end-stage renal disease (ESRD). BMJ Case Rep. 2019;12(9):e230288. doi: 10.1136/bcr-2019-230288

Ago M, Ago K, Hara K, Kashimura S, Ogata M. Toxicological and histopathological analysis of a patient who died nine days after a single intravenous dose of methamphetamine: a case report. Leg Med. 2006;8:235-239. doi: 10.1016/j.legalmed.2006.03.002

Richards JR. Rhabdomyolysis and drugs of abuse. J Emerg Med. 2000;19(1):51-56. doi: 10.1016/s0736-4679(00)00180-3

Halpin LE, Gunning WT, Yamamoto BK. Methamphetamine causes acute hyperthermia‐dependent liver damage. Pharmacol Res Perspect. 2013;22;1(1):e00008. doi: 10.1002/prp2.8

Shannon B, Borron SW, Snook CP, et al. Haddad and Winchesters clinical management of poisons and drug overdose. Systems. 2006;133:1.

Wang T, Xu C, Xu S, et al. Untargeted metabolomics analysis by gas chromatography/time‐of‐flight mass spectrometry of human serum from methamphetamine abusers. Addict Biol. 2021;26(6):e13062. doi: 10.1111/adb.13062

Nazari A, Zahmatkesh M, Mortaz E, Hosseinzadeh S. Effect of methamphetamine exposure on the plasma levels of endothelial-derived microparticles. Drug Alcohol Depend. 2018;186:219-225. doi: 10.1016/j.drugalcdep.2018.02.015

Zhao T, Zhai C, Song H, et al. Methamphetamine-induced cognitive deficits and psychiatric symptoms are associated with serum markers of liver damage. Neurotox Res. 2020;37(1):67-76. doi: 10.1007/s12640-019-00115-w

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Published

2024-03-30

How to Cite

Al-Tayeb, A.-N. O., Abubakr, M. H., Elrheima, H. A., Habbani, A. K., & Elrasul, R. Y. H. (2024). Assessment of serum creatinine, urea, and aminotransferase levels among methamphetamine addicted individuals in Khartoum State. European Journal of Clinical and Experimental Medicine, 22(1), 68–72. https://doi.org/10.15584/ejcem.2024.1.10

Issue

Vol. 22 No. 1 (2024)

Section

ORIGINAL PAPERS

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