Acne vulgaris during pregnancy – management ensuring both maternal and fetal safety

Authors

DOI:

https://doi.org/10.15584/ejcem.2024.3.19

Keywords:

acne vulgaris, dermatology, pregnancy

Abstract

Introduction and aim. Acne vulgaris represents a condition commonly encountered by women during pregnancy. However, its treatment becomes particularly demanding when occurring during gestation. The aim of this review is to present multiple strategies for management of acne in pregnant women, prioritizing both maternal and fetal safety.

Material and methods. Review and analysis of the scientific literature available in November and December 2023.

Analysis of literature. The study describes commonly used topical treatments and oral medications emphasizing difficulty and responsibility of assessing the safety of drug use during pregnancy. Apart from that, the importance of skin care is stressed with a focus on usage appropriate to the condition and pregnancy-safe cosmetics. The influence of diet and physical activity on acne development is also underlined, as well as the significant association between acne and mental health.

Conclusion. Dealing with acne during pregnancy might be difficult; however, there are effective and safe acne treatments suitable for pregnant women, along with various supportive approaches. Considering above, the authors highlight a holistic nature of acne management that includes not just medication but also procedural interventions, skin care practices, diet, physical activity, and psychological support.

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References

Dréno B, Blouin E, Moyse D, Bodokh I, Chantal Knol A, Khammari A. Acne in Pregnant Women: A French Survey. Acta Derm Venereol. 2013;94(1):82-83. doi: 10.2340/00015555-1594

Bechstein SK, Ochsendorf F. Acne and rosacea in pregnancy. Hautarzt. 2017;68(2):111-119. doi: 10.1007/s00105-016-3918-8

Bergler-Czop B. Trądzik. In: Contemporary dermatology. 1st ed. Rudnicka L, Olszewska M, Rakowska A, Sar-Pomian M. Warszawa: PZWL Wydawnictwo Lekarskie; 2022;2:22-25.

Ly S, Kamal K, Manjaly P, Barbieri JS, Mostaghimi A. Treatment of Acne Vulgaris During Pregnancy and Lactation: A Narrative Review. Dermatol Ther (Heidelb). 2023;13(1):115-130. doi: 10.1007/s13555-022-00854-3

Kutlu Ö, Karadağ AS, Ünal E, et al. Acne in pregnancy: A prospectivemulticenter, cross-sectionalstudy of 295 patients in Turkey. Int J Dermatol. 2020;59:1098-1105.

Awan SZ, Lu J. Management of severe acne during pregnancy: A case report and review of the literature. Int J Womens Dermatol. 2017;3(3):145-150. doi: 10.1016/j.ijwd.2017.06.001

Bedi A, Khatu SS, Poulkar CB, Palaskar N, Chaudhari ND, Patokar AS. The Spectrum of Mucocutaneous Manifestation during Pregnancy: An Observational Study of 170 Pregnant Women Visiting a Tertiary Care Hospital. Medical Journal of Dr. D.Y. Patil Vidyapeeth. 2023;16(4):521-527. doi: 10.4103/2589-8302.335113

Yang CC, Huang YT, Yu CH, Wu MC, Hsu CC, Chen W. Inflammatory facial acne during uncomplicated pregnancy and post-partum in adult women: a preliminary hospital-based prospective observational study of 35 cases from Taiwan. J Eur Acad Dermatol Venereol. 2016;30(10):1787-1789. doi: 10.1111/jdv.13667

Chien AL, Qi J, Rainer B, Sachs DL, Helfrich YR. Treatment of acne in pregnancy. J Am Board Fam Med. 2016;29:254-262.

Tan I, Cohen BA. Managing Acne Vulgaris During Pregnancy and Lactation. Dermatology Times. 2023;44(7).

Matin T, Goodman MB. Benzoyl Peroxide. National Library of Medicine. https://www.ncbi.nlm.nih.gov/books/NBK537220/. Updated October 10, 2022. Accessed November 29, 2023.

Graber E. Acne vulgaris: Overview of management. UpToDate. https://www.uptodate.com/contents/acne-vulgaris-overview-of-management/. Updated February 23, 2023. Accessed November 29, 2023.

Mills OH Jr, Kligman AM, Pochi P, Comite H. Comparing 2.5%, 5%, and 10% benzoyl peroxide on inflammatory acne vulgaris. Int J Dermatol. 1986;25(10):664-667. doi: 10.1111/j.1365-4362.1986.tb04534.x

Tuszyński PK. Acne treatment during pregnancy. In: Drugs and pregnancy. Safe pharmacotherapy and supplementation of pregnant women. 2nd ed. Kraków: Wydawnictwo Farmaceutyczne; 2023:382-388.

Putra IB, Jusuf NK, Dewi NK. Skin Changes and Safety Profile of Topical Products During Pregnancy. J Clin Aesthet Dermatol. 2022;15(2):49-57.

Pugashetti R, Shinkai K. Treatment of acne vulgaris in pregnant patients. Dermatol Ther. 2013;26(4):302-311. doi: 10.1111/dth.12077

Murase JE, Heller MM, Butler DC. Safety of dermatologic medications in pregnancy and lactation: Part I. Pregnancy. J Am Acad Dermatol. 2014;70(3):401-414.

Reszke R, Szepietowski J. Azelaic acid in dermatological treatment – current state of knowledge. Przegl Dermatol. 2016;103:337-343. doi: 10.5114/dr.2016.61785

Măgerușan ȘE, Hancu G, Rusu A. A Comprehensive Bibliographic Review Concerning the Efficacy of Organic Acids for Chemical Peels Treating Acne Vulgaris. Molecules. 2023;28(20):7219. doi: 10.3390/molecules28207219

Wolverton SE. Comprehensive Dermatologic Drug Therapy. 3rd Edition, Philadelphia: Saunders Elsevier; 2012.

Kirtschig G, Schaefer C. Dermatological medications and local therapeutics. In: Drugs during pregnancy and lactation. 3rd ed. Schaefer C, Peters P, Miller RK. Oxford: Elsevier limited; 2015;467-492.

Plewig G. Diseases of skin appendages. In: Dermatology. 3rd ed. Braun-Falco. Lublin: Wydawnictwo Czelej sp. z o.o.; 2017:1017-1041.

Bechtold A, Zalewska -Janowska A. Diseases of the sebaceous and sweat glands. In: Dermatology in the primary health care doctor's office. 1st ed. Zalewska-Janowska A, Błaszczyk H. Warszawa: PZWL Wydawnictwo Lekarskie; 2021:191-215.

Wolska H. Seborrheic diseases. In: Dermatology in practice. 2nd ed. Błaszczyk-Kostanecka M, Wolska H. Warszawa: PZWL Wydawnictwo Lekarskie; 2017:147-158.

Lookingbill DP, Chalker DK, Lindholm JS, et al. Treatment of acne with a combination clindamycin/benzoyl peroxide gel compared with clindamycin gel, benzoyl peroxide gel and vehicle gel: combined results of two double-blind investigations. J Am Acad Dermatol. 1997;37(4):590-595. doi: 10.1016/s0190-9622(97)70177-4

Acne and related disorders. In: Dermatology. 2nd ed. Rycroft RJG, Robertson SJ, Wakelin SH. Boca Raton: CRC Press Taylor & Francis Group; 2010:76-81.

Daniel S, Doron M, Fishman B, Koren G, Lunenfeld E, Levy A. The safety of amoxicillin and clavulanic acid use during the first trimester of pregnancy. Br J Clin Pharmacol. 2019;85(12):2856-2863. doi: 10.1111/bcp.14118

Lin KJ, Mitchell AA, Yau WP, Louik C, Hernández-Díaz S. Maternal exposure to amoxicillin and the risk of oral clefts. Epidemiology. 2012;23(5):699-705. doi: 10.1097/EDE.0b013e318258cb05

Romøren M, Lindbæk M, Nordeng H. Pregnancy outcome after gestational exposure to erythromycin - a population-based register study from Norway. Br J Clin Pharmacol. 2012;74(6):1053-1062. doi: 10.1111/j.1365-2125.2012.04286.x

Kong YL, Tey HL. Treatment of acne vulgaris during pregnancy and lactation. Drugs. 2013;73(8):779-787. doi: 10.1007/s40265-013-0060-0

Woroń J. Drug therapy during pregnancy. In. Pregnancy and chronic diseases. 1st ed. Olesińska M, Teliga-Czajkowska J. Warszawa: PZWL Wydawnictwo Lekarskie; 2023:741-750.

Yang YG, Zou XB, Zhao H, Zhang YJ, Li HJ. Photodynamic therapy of condyloma acuminata in pregnant women. Chin Med J (Engl). 2012;125(16):2925-2928.

Taub AF. Procedural treatments for acne vulgaris. Dermatol Surg. 2007;33(9):1005-1026. doi: 10.1111/j.1524-4725.2007.33215.x

Waleśkiewicz-Ogórek K. Skin care during pregnancy. Forum of Obstetrics and Gynecology.

Del Rosso JQ. The role of skin care as an integral component in the management of acne vulgaris: part 1: the importance of cleanser and moisturizer ingredients, design, and product selection. J Clin Aesthet Dermatol. 2013;6(12):19-27.

Deda A. Acne vulgaris. In: Basics of therapeutic cosmetology. 1 st ed. Wcisło-Dziadecka D. Warszawa: PZWL Wydawnictwo Lekarskie; 2022:1-38.

Li H, Zheng J, Wang H et al. Maternal cosmetics use during pregnancy and risks of adverse outcomes: a prospective cohort study. Sci Rep. 2019;9:8030. doi 10.1038/s41598-019-44546-z

Dulska A, Kubiak B, Drosdzol-Cop A, Dudek M, Pawlica PJ. Care and cosmetic treatments during pregnancy. Forum of Obstetrics and Gynecology.

Dreno B, Bagatin E, Blume-Peytavi U, Rocha M, Gollnick H. Female type of adult acne: Physiological and psychological considerations and management. Journal of the German Society of Dermatology. 2018;16(10):1177-1301. doi: 10.1111/ddg.13664

Kowalska H, Sysa-Jędrzejowska A, Woźniacka A. Role of diet in the etiopathogenesis of acne. Dermatology Review. 2018;105:51-62. doi: 10.5114/dr.2018.74166

Pappas A. The relationship of diet and acne: A review. Dermatoendocrinol. 2009;1(5):262-267. doi: 10.4161/derm.1.5.10192

Aghasi M, Golzarand M, Shab-Bidar S, Aminianfar A, Omidian M, Taheri F. Dairy intake and acne development: A meta-analysis of observational studies. Clin Nutr. 2019;38(3):1067-1075. doi: 10.1016/j.clnu.2018.04.015

Bastos Maia S, Rolland Souza AS, Costa Caminha MF, et al. Vitamin A and Pregnancy: A Narrative Review. Nutrients. 2019;11(3):681. doi: 10.3390/nu11030681

Downs DS, Chasan-Taber L, Evenson KR, Leiferman J, Yeo S. Physical activity and pregnancy: past and present evidence and future recommendations. Res Q Exerc Sport. 2012;83(4):485-502. doi: 10.1080/02701367.2012.10599138

Karwańska A, Kulbat A, Świercz K, et al. The impact of physical activity, diet and stress on acne vulgaris. Pathogenesis and therapeutic procedures. J Educ Health Sport. 2023;13(3):18-23.

Picardi A, Mazzotti E, Pasquini P. Prevalence and correlates of suicidal ideation among patients with skin disease. J Am Acad Dermatol. 2006;54(3):420-426. doi: 10.1016/j.jaad.2005.11.1103

Makara-Studzińska M, Wdowiak A, Plewik I, Kryś KM. Sexuality of pregnant women. Seksuologia Polska. 2011;9(2):85-90.

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Published

2024-09-30

How to Cite

Kurzeja, J., Maciejewska, D., Bartczak, M., Guderska, U., Urbanek, A., Rasmus-Czternasta, A., & Czternasty, F. (2024). Acne vulgaris during pregnancy – management ensuring both maternal and fetal safety. European Journal of Clinical and Experimental Medicine, 22(3), 646–652. https://doi.org/10.15584/ejcem.2024.3.19

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