Bilberry plant – prospects of new applications in prevention and supportive treatment of civilisation diseases
Keywords:
bilberry, anthocyanins, phenolic acids, oxidative stressAbstract
Bilberry fruits are part of a traditional diet contributing to the intake of natural antioxidants, such as anthocyanins and phenolic acids. A specific nature of these agents promotes a wide use of bilberry in prevention and supportive treatment of many civilisation diseases, including cardiovascular diseases, cancer, neurodegenerative and other age-related diseases.
Downloads
References
Kohlműmzer S.: Farmakognozja , PZWL, 2000
Ożarowski A.: Ziołolecznictwo, PZWL, 1980
van Wyk B-E, Wink M.: Rośliny lecznicze świata, MedPharm Polska 2008
Duthie S.J. Berry phytochemicals, genomic stability and cancer: Evidence for chemoprotection at several stages in the carcinogenic process. Mol. Nutr. Food Res. 2007; 51, 665-674
Prior R.L., Wu X.: Anthocyanins: Structural characteristics that results in unique metabolic patterns and biologicals activities. Free Radic. Res. 2006; 40, 1014-1028
Felgines C., Terier O., Besson C., Fraisse D., Lamaison J.L., Remesy C.: Blackberry anthocyanins are slightly bioavailable in rats, J. Nutr. 2002; 132 (6), 1249-1253
Erlund I., Freese R., Marniemi J., Hakala P., Alfthan G.: Bioavailability of quercitin from berries and the diet, Nutr. Cancer 2006; 54(1), 13-17
Canter P.H., Ernst E.: Anthocyanosides of Vaccinium myrtillus (bilberry) for night vision-a systematic review of placebo-controlled trials. Surv. Ophthalmol. 2004; 49, 38-50
Zafra-Stone S., Yasmin T., Bagchi M., Chatterjee a, Vinson J.A., Benicia C.A.: Berry anthocyanins as novel antioxidants in human health and disease prevention. Mol. Nutr. Food Res. 2007; 51(6), 675-683
Matsunaga N., Imai S., Inokuchi Y., Shimazawa M., Yokata S., Araki Y., Hara H.: Bilberry and its main constituents have neuroprotective effects against retinal neuronal damage in vitro and in vivo. Mol. Nutr. Food Res. 2009; 53, 869-877
Kmieć K.: Rośliny z zielnika S.Wyspiańskiego , Panacea, 2008; 2 (23)
Nijveldt R.J.,Nood E., Hoom D.E.C., Boelens P.G., Norren K., Leeuwen P.A.M.: Flavonoids: a review of probable mechanisms of action and potential applications, Am J. Clin. Nutr. 2001; 74, 418-425.
Pietta P.G.: Flavonoids as antioxidants, J. Nat. Prod 2000; 63(7), 1035-1042
Seeram N.P.: Berry fruits:compositional elements, biochemical activities, and the impact of their intake on human health, performance, and disease, J. Agric. Food Chem., 2008; 13; 56(3), 627-629
Dai J., Gupte A., Gates L., Mumper R.J.: A comprehensive study of anthocyanin-containing extracts from selected blackberry cultivars: extraction methods, stability, anticancer properties and mechanisms; Food Chem.Toxicol. 2009; 47; 837-847
Katsube N., Iwashita T., Tsushida T., Hamaki K., Kobori M.: Induction of apoptosis in cancer cells by bilberry (Vaccinium myrtillus) and the anthocyanins. J. Agric. Food Chem. 2003; 51, 68-75
Rahman I., Biswas S.K., Kirkham P.A.: Regulation of inflammation and redox signaling by dietary polyphenols. Biochem. Pharmacol. 2006; 72(11), 1439-1452
Lee K.F., Chung W.Y., Benzie I.F.: Urine 8-oxi-7,8-dihydro-2’-deoxyguanosine(8-oxodG), a specific marker of oxidative stress, using direct, isocratic LC-MS/MS: Method evaluation and application in study of biological variation in heathy adults. Clin. Chem. Acta 2010; 411, 416-422
Freese R., Vaarala O., Turpeinen A.M., Mutanen M.: No difference in platelet activation or inflammation markers after diets rich or poor in vegetables, berrirs and apple in healthy subjects. Eur. J. Nutr. 2004; 43, 175-182
Karlsen A., Paur I., Bohn S.K., Sakhi G.I., Borge G.I., Serafini M., Erlund I., Laake P., Tonstad S., Blomhoff R.: Bilberry juice modulates plasma concentration of NF-kappaB related inflammatory markers in subjects at increased risk of CVD. Eur. J. Nutr. 2010; 49(6), 435-355
Seeram N.P.: Berry fruits for cancer prevention: current status and future prospects. J. Agric. Food Chem. 2008; 56(3), 630-635
Seeram N.P., Adams L.S., Zhang Y., Lee R., Sand D., Scheuller H.S., Heber D.: Blackberry, black raspberry, blueberry, cranberry, red raspberry, and strawberry extracts inhibit growth and stimulate apoptosis of human cancer cells in vitro, J. Agric Food Chem. 2006; 54, 9329-9339
Srivastava A., Akoh C.C., Fischer J., Krewer G.: Effect of antocyanin fractions from selected cultivars of Georgia-grown blueberries on apoptosis and phase II enzymem, J. Agric. Food Chem. 2007; 55(8), 3180-3185
Yi W., Fischer J., Krewer G., Akoh C.C.: Phenolic compounds from blueberries can inhibit colon kancer cell proliferation and induce apoptosis, J. Agric. Food Chem. 2005; 53, 7320-7329
Bao L., Yao X.S., Tsi D., Yau C.C., Chia C.S., Nagai H., Kurihara H.: Protective effects of bilberry ((Vaccinium myrtillus) extract on KBrO3-induced kidney damage In mice, ,J. Agric. Food Chem, 2008; 56(2), 420-425
Bao L., Yao X.S., Yau C.C., Tsi D., Chia C.S., Nagai H., Kurihara H.: Protective effects of bilberry ((Vaccinium myrtillus) extract on restraint stress-induced liver damage In mice, J. Agric. Food Chem. 2008; 56,(17), 7803-7807
Puupponen-Pimiä R., Nohynek L., Ammann S., Oksman- Caldentey K.M., Buchert J.: Enzyme assisted processing increases antimicrobial and antioxidant activity of bilberry, J. Agric. Food Chem. 2008; 56(3), 681-688
Bermudez-Soto M.J., Larrosa M., Garcia-Cantalejo J.M., Spin J.C., Tomas-Barberan F.A., Garcia-Conesa M.T.: Up regulation of tumor suppressor carcinoembryonic antygen-related cell adhesion molekule 1 in human colon cancer Caco-2 cells following repetitive exposure to dietary levels of a polyphenol-rich chokeberry juice. J.Nutr. Biochem., 2007; 18, 259-271.
Coates E.M., Popa G., Gill C.I., McCann M.J., McDougall G.J., Steward D., Rowland I.: Colon –available raspberry polyphenols exhibit anti-cancer pisk. J Nutr. 2006; 136, 3046-3053.
Seeram N.P.: Berty fruits for kancer prevention current status and future prospects. J. Agric. Ford Chem., 2008; 56, 630-635.
Galvano F., La Fauci L., Lazzarino G., Fogliano V., Ritieni A., Ciapellano S., Battistini N.C., Tavazzi B., Galvano G.: Cyanidins: metabolizm and biological properties. J. Nutr. Biochem. 2004; 15, 2-11.
Zhao C., Giusti M.M., Malik M., Moyer M.P., Magnuson B.A.: Effects of commercial anthycyanin-rich extracts on colonic kancer and nontumorigenic colonic cell growth. J.Agric. Food Chem. 2004; 52, 6122-6128.
Boot C., Hargreaves D.F., Hadfield J.A., McGrown A.T., Potten C.S.: Isoflavones inhibit intestinal epithelial cell proliferatin and induce apoptosis In vitro. Br. J. Cancer, 1999; 80; 1550-1557.
Oshima M., Dinchuk J.E., Kargman S.L., Hancook B., Kong E., Trzaskos J.M., Evans J.F., Tapeto M.M.: Suppression of intestinal polyposis In Apc 716 knockout mice by inhibition of cyclooxygenase 2 (COX-2). Cell, 1996; 87, 803-809.
Prescot S.M., White R.L.: Self-promotion? Intimate connections between APC and prostaglandin H synthase-2. Cell, 1996; 87, 783-786.
Baghi D., sen C.K., Baghi M., Atalay M.: Anti-angiogenic, antioxidant, and anti-carcinogenic properties of a novel anthocyanin-rich berty extract formula. Biochemistry (Mosc.) 2004; 69, 75-80.
Brandstetter H., Grams F., Glitz D., Lang A., Huber R., Bode W., Krell H.W., Engh R.A.: The 1,8-A crystal structure of a matrix metalloproteinase 8-barbiturate inhibitor complex reveals a previously unobserved mechanizm for collagenase substrate recognition. J.Biol. Chem. 2001; 276, 17405-17412.
Fimognari C., Berti F., Usze M., Cantelli-Forti G., Hrelia P.: Induction of apoptosis In two human leukemia cell lines as well as differentiation In human promyelocytic Wells by cyanidin-3-O-beta-glucopyranoside. Biochem Pharmacol. 2004; 67, 2047-2056.
Rodrigo K.A., Rawal Y., Renner R.J., Schawartz S.J., Tian Q., Arsen P.E.:, Mallery S.R.: Suppression of the tumorigenic phenptype In human oral squamous cell carcinoma Wells by an etanol extract derived from freeze-dried black raspberries. Nutr. Cancer, 2006; 54, 58-68
Serafino A., Sinibaldi-Vallebona P., Lazzarino G., Tavazzi B., Rasi G., Pierimarchi P., Wells induced by cyanidin-3-O-beta- glucopyranoside. FASEB J. 2004; 18, 1940-1942.
Stoner G.D., wang L.S.,Casto B.C.: Andreola F., Moroni G., Galvano G., Galvano F., Garaci E.: Differentiation of human melanoma Laboratory and clinical studiem of cancer chemoprevention by antioxydants In berries. Carcinogenesis, 2008; 29; 1665-1674.
Thomasset S., Berty D.P., Cai H., West K., Marzyło T.H., Marsden D., Brown., Dennison A., Garcea G., Miller A., Hemingway D., Steward W.P., Gescher A.J.: Pilot study of oral anthycyanis for colorectal cancer chemoprevention. Cancer Prev. Res. 2009; 2; 625-633.
Janeczko Z., Bochenek B., Jurczyszyn A.: Właściwości biologiczne resweratrolu i możliwości jego stosowania w terapii szpiczaka mnogiego. Leki ziołowe. Panacea 2009, 2(27), 9-11.
Lyons M.M., Toma R.B., Cho S.Y., Reiboldt W., Lee J., van Breemen R.B. Resveratrol in raw and baked blueberries and bilberries. J. Agric. Food Chem. 2003, 51(20), 5867-5870.
Rimando A.M., Kalt W., Magee J.B., Dewey J., Ballington J.R. Resveratrol, pterostilbene and piceatannol in vaccinium berries. J. Agric. Food Chem. 2004, 52(15), 4713-4719.
Scalbert A., Williamson G.: Dietary intake and bioavailability of polyphenols. J. Nutr. 2000; 130 (supl. 8S); 2073S-2085S.
Biesalski H.K.: Polyphenols and inflamation: Basic interactions. Curr. Opin. Clin. Nutr. Metab. Care 2007; 10(6), 724-728.
Guo W., Kong E., Meydani M.: Dietary polyphenols, inflammation and cancer. Nutr. Cancer 2009; 61(6), 807-810.
Heinonen M.: Antioxidant activity and antimicrobial effect of berry phenolics-a Finnish perspective. Mol. Nutr. Food Res. 2007; 51(6), 684-691.
Sawicka T., Drozd J., Prosińska J., Borkowski B.: Aktywność immunostymulacyjna niektórych fenolokwasów i związków estrowych. Herba Pol., 1994; 40, 31-34.
Drozd J.: Zmiany aktywności immunostymulującej farmakopealnych surowców garbnikowych zachodzące podczas przechowywania. Biul. Inst. Leków, 1997; 4, 60-65.
Sawicka T., Rogala E., Strzelecka H., Drozd J., Prosińska J., Radomska-Leśniewska D., Skopińska-Różewska E.: Adaptacja testów biologicznych do oceny aktywności preparatów jeżówki purpurowej, część I-badanie in vivo (38-42), część II-badanie invitro. Terapia, 2001; 3 (2), 43-46.
Prosińska J., Sawicka T., Drozd J.: Investigations of the thymomimetic activity of a selected phytopharmaceutical preparation-Reumaherb tablets by flow cytometry; Acta Pol. Pharm-Drug Res 2002; 59, 267-275..
Drozd J. Sawicka T., Prosińska J.: Estimation of humoral aktivity of Eleuterococcus senticosus, Acta Polon Pharm-Drug Res 2002; 59, 395-400.
Drozd J., Tautt J.: Badania porównawcze aktywności immunostymujującej Fructus Myrtilli ze związkami o ustalonym działaniu na układ odpornościowy. Biul.Inst.Leków, 2002; 46, 1-2, 45-48.
Lu Y., Foo L.Y.: Polyphenolics of Salvia-a review. Phytochem, 2002; 59(2), 117-140.
Drozd J., Anuszewska E.: The influence of plant materiale, containing ellagic acid and selected antibiotics on immunological response in mice, Acta Pol. Pharm-Drug Res, 2005; 62,3,237-240.
Drozd J., Anuszewska E.: Effects of bilberry fruit aqueous extract and selected antibiotics on immune response in mice, Acta Pol. Pharm-Drug Res 2009; 66,2,181-184.
Fresco P., Borges F., Diniz C., Marques M.P.: New insights on the anticancer properties of dietary polyphenols. Med. Res. Rev. 2006; 26(6), 747-766.
Neto C.C.: Cranberry and bluberry: evidence for protective sffects against cancer and vascular diseases. Mol. Nutr. Food Res. 2007; 51(6), 652-664.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2013 Medical Journal of the Rzeszow University and the National Medicines Institute, Warsaw

This work is licensed under a Creative Commons Attribution 4.0 International License.
Our open access policy is in accordance with the Budapest Open Access Initiative (BOAI) definition: this means that articles have free availability on the public Internet, permitting any users to read, download, copy, distribute, print, search, or link to the full texts of these articles, crawl them for indexing, pass them as data to software, or use them for any other lawful purpose, without financial, legal, or technical barriers other than those inseparable from having access to the Internet itself.
All articles are published with free open access under the CC-BY Creative Commons attribution license (the current version is CC-BY, version 4.0). If you submit your paper for publication by the Eur J Clin Exp Med, you agree to have the CC-BY license applied to your work. Under this Open Access license, you, as the author, agree that anyone may download and read the paper for free. In addition, the article may be reused and quoted provided that the original published version is cited. This facilitates freedom in re-use and also ensures that Eur J Clin Exp Med content can be mined without barriers for the research needs.




