The importance and characteristics of fatty acids elongases

Authors

  • Jagoda Drąg Z Zakładu Analityki Biochemicznej, Wydział Farmaceutyczny z Oddziałem Analityki Medycznej, Collegium Medicum Uniwersytetu Jagiellońskiego
  • Anna Goździalska Z Zakładu Analityki Biochemicznej, Wydział Farmaceutyczny z Oddziałem Analityki Medycznej, Collegium Medicum Uniwersytetu Jagiellońskiego
  • Anna Gawędzka Z Zakładu Analityki Biochemicznej, Wydział Farmaceutyczny z Oddziałem Analityki Medycznej, Collegium Medicum Uniwersytetu Jagiellońskiego
  • Małgorzata Knapik-Czajka Z Zakładu Analityki Biochemicznej, Wydział Farmaceutyczny z Oddziałem Analityki Medycznej, Collegium Medicum Uniwersytetu Jagiellońskiego
  • Adrian Kużdżał Z Instytutu Fizjoterapii, Wydział Medyczny, Uniwersytet Rzeszowski; Z Krakowskiej Wyższej Szkoły Promocji Zdrowia https://orcid.org/0000-0002-5685-3139
  • Jerzy Jaśkiewicz Z Zakładu Analityki Biochemicznej, Wydział Farmaceutyczny z Oddziałem Analityki Medycznej, Collegium Medicum Uniwersytetu Jagiellońskiego

Keywords:

elongases, elongation of fatty acids, fatty acid synthase (FAS), acetyl-Co A carboxylase (ACC)

Abstract

In humans and other mammals, the fatty acids, taken up by the diet or synthesized de novo, are further elongated into very long chain fatty acids. Elongation process is catalyzed by transmembrane enzymes, which are found mainly in endoplasmic reticulum. Fatty acid elongases enzymes can be divided into two major groups: elongases involved in the elongation of saturated and monounsaturated VLCFA (ELOVL 1, 3, 6, 7) and elongases of polyunsaturated fatty acids (ELOVL 2, 5). ELOVL 4, due to the specificity of substrates, is not included in any of these groups. This article describes in details the genes that encode elongases as well as role of these enzymes in a lipid metabolism.

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Published

2012-03-30

How to Cite

Drąg, J., Goździalska, A., Gawędzka, A., Knapik-Czajka, M., Kużdżał, A., & Jaśkiewicz, J. (2012). The importance and characteristics of fatty acids elongases. European Journal of Clinical and Experimental Medicine, 10(1), 109–115. Retrieved from https://journals.ur.edu.pl/ejcem/article/view/12787

Issue

Vol. 10 No. 1 (2012): Medical Journal of the Rzeszow University and the National Medicines Institute, Warsaw

Section

REVIEW PAPERS

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Copyright (c) 2012 Medical Journal of the Rzeszow University and the National Medicines Institute, Warsaw

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