The lack of association of rs7951 C3 complement polymorphism with systemic lupus erythematosus patients

Authors

  • Izabela Korczowska Z Zakładu Reumatologii i Immunologii Klinicznej, Uniwersytet Medyczny w Poznaniu
  • Dorota Trzybulska Z Zakładu Reumatologii i Immunologii Klinicznej, Uniwersytet Medyczny w Poznaniu https://orcid.org/0000-0002-2883-1119
  • Natalia Pewińska Z Zakładu Reumatologii i Immunologii Klinicznej, Uniwersytet Medyczny w Poznaniu
  • Paweł Hrycaj Z Zakładu Reumatologii i Immunologii Klinicznej, Uniwersytet Medyczny w Poznaniu

Keywords:

systemic lupus erythematosus, genetic analysis, C3 complement

Abstract

Introduction: Systemic lupus erythematosus (SLE) is a complex multisystem autoimmune disease. The purpose of the study was to estimate the prevalence of polymorphism in C3 rs7951 gene in the control group (healthy people) and in the study group (people suffering from the SLE).

Materials and methods: Study has been subjected to 99 people suffering from the SLE, between 20-70 years old. Biological material used in the studies was DNA. The method of salting out was used to obtain the DNA, amplificated with PCR method and underwent enzymatic hydrolysis with usage of endonuclease HindIII.

Results: In comparison the study group to the control one the prevalence of risk allele T in gene C3 did not appear to be higher.

Conclusions: The study revealed that polymorphism of C3 gene (rs7951) does not contribute to prevalence of SLE.

Supporting Agencies

Work funded by the project MNiSzW: N N402 267836

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Published

2011-12-30

How to Cite

Korczowska, I., Trzybulska, D., Pewińska, N., & Hrycaj, P. (2011). The lack of association of rs7951 C3 complement polymorphism with systemic lupus erythematosus patients. European Journal of Clinical and Experimental Medicine, 9(4), 416–423. Retrieved from https://journals.ur.edu.pl/ejcem/article/view/12881

Issue

Vol. 9 No. 4 (2011): Medical Journal of the Rzeszow University and the National Medicines Institute, Warsaw

Section

ORIGINAL PAPERS

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Copyright (c) 2011 Medical Journal of the Rzeszow University and the National Medicines Institute, Warsaw

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