Increased chemokine CCL3/MIP-1 alpha serum level in severe bronchial asthma
Keywords:
chemokines, severe bronchial asthma, type 1 T cells, type 2 T cellsAbstract
Introduction. Bronchial asthma is a chronic inflammatory disease with the dominant role of type 2 T helper cells. In some asthma phenotypes, particularly in severe bronchial asthma, type 1 T helper cells may participate. Data on the role of CCL3/MIP-1 alpha, that is the type 1 chemokine, in the chronic asthma are divergent.
The aim of the study was to assess the relationship between the serum level of CCL3/MIP-1 alpha in asthmatics and the stage of the disease. 27 patients with chronic asthma, including 14 patients with mild-to-moderate asthma and 13 patients with severe asthma, and 22 controls were included into the study. Serum level of CCL3/MIP-1 alpha and total IgE level were measured.
Results and conclusion: CCL3/MIP-1 alpha levels were significantly higher in severe asthmatics than in mild-tomoderate asthma patients (p=0.02) and in the controls (p=0.001). There were no correlations between level of CCL3/MIP-1 alpha and age, asthma duration and total IgE level. Increased serum CCL3/MIP-1 alpha level may indicate the significance of Th1 response in the pathophysiology of chronic severe bronchial asthma.
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