The rs9939609T>A polymorphism of the FTO gene and overweight in survivors of ALL

Authors

  • Szymon Skoczen Chair of Clinical Immunology and Transplantation, Jagiellonian University Krakow, Poland
  • Miroslaw Bik-Multanowski Chair of Pediatrics, Jagiellonian University Krakow, Poland
  • Walentyna Balwierz Department of Oncology and Hematology, Jagiellonian University Krakow, Poland
  • Jacek J. Pietrzyk Chair of Pediatrics, Jagiellonian University Krakow, Poland

Keywords:

overweight, leukemia, genetic predisposition, population, FTO gene, cranial irradiation

Abstract

Background: Overweight is a serious late complication of acute lymphoblastic leukemia (ALL). The aim of the study was to assess the role of the rs9939609T>A polymorphism of the FTO gene in development of overweight in ALL survivors.

Methods: Genotyping for the above genetic variant was performed in 191 patients, who completed treatment for ALL.

Results: The presence of the rs9939609A allele correlated with post-treatment overweight incidence in patients receiving cranial radiotherapy, whereas the rs9939609T allele seemed to protect against overweight development.

Conclusion: The rs9939609T>A variant can influence overweight risk in selected patients with ALL.

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References

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Published

2011-06-30

How to Cite

Skoczen, S., Bik-Multanowski, M., Balwierz, W., & Pietrzyk, J. J. (2011). The rs9939609T>A polymorphism of the FTO gene and overweight in survivors of ALL. European Journal of Clinical and Experimental Medicine, 9(2), 174–177. Retrieved from https://journals.ur.edu.pl/ejcem/article/view/12955

Issue

Vol. 9 No. 2 (2011): Medical Journal of the Rzeszow University and the National Medicines Institute, Warsaw

Section

ORIGINAL PAPERS

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Copyright (c) 2011 Medical Journal of the Rzeszow University and the National Medicines Institute, Warsaw

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