The influence of oligosaccharide-containing formula feeding on establishment of intestinal biocenosis and protective functions of child’s organism

Authors

  • S. Nyankovskyy Danylo Halytskiy Lviv National Medical University, Ukraine, Department of Faculty and Hospital Pediatrics
  • O. Ivakhnenko Danylo Halytskiy Lviv National Medical University, Ukraine, Department of Faculty and Hospital Pediatrics

Keywords:

Prebiotics, FOS, GOS, oligosaccharides, intestinal flora, immunonutrition, immune system, infants

Abstract

Dietary modulation of the intestinal microflora and immune response is one of the important prob-lems in the nutritional sciences today. Human milk oligosaccharides play an important role in postnatal development of the intestinal flora and protective functions of child's organism. The present review sum-marizes the data of experimental research and clinical studies concerning the possible effects of probiotic mixture of galacto-oligosaccharides and fructo-oligosaccharides in Ukraine. The data demonstrate that prebiotic oligosaccharides such as studied mixture provide beneficial effects for formula fed infants. The results from several studies in Ukraine demonstrate that probiotic oligosaccharides stimulate the growth of bifidobacteria and lactobacilli, reduce the growth of pathogens, decrease faecal pH, normalize the stool consistency and modulate immune system as human milk does. 

Downloads

Download data is not yet available.

References

Abreu MT, Fukata M, Arditi M. TLR signaling in the gut in health and disease. J Immunol 2005;174:4453–60.

Arayev NL, Kaplina LE, Zborzyk OP, et al. An experience of using of adapted formulas with prebiotics “Nutrilon-1” and “Nutrilon-2” in infants. International Congress „Healthy nutrition, dysbiosis and it prophylaxis with prebiotic-containing products of new generation”; Kyiv; 2003, 23–4.

Agostoni C, Axelsson I, Braegger C, et al. Probiotic Bacteria in Dietetic Products for Infants: A Commentary by the ESPGHAN Committee on Nutrition. J Pediatr Gastroenterol Nutr 2004; 38:365–74.

Bjorksten B, Sepp E, Julge K, er al. Allergy development and the intestinal microflora during the first year of life. J Allergy Clin Immunol 2001,108:516–20.

Boehm G., Stahl B., Jelinek J, et al. Prebiotic carbohydrates in human milk and formulas. Acta Paediatrica 2005; 94:18–21.

Boehm G, Stahl B, Moro G. Prebiotics in infant formulas. Immune modulators during infancy. Nutrafoods 2005; 4:51–57.

Boehm G., Stahl B. Oligosaccharides. In: Mattila-Sandholm T, editor. Functional dairy products.

Cambridge: Woodhead Publ.; 2003, p 203–43.

Boehm G, Fanaro S, Jelinek J, Stahl B, Marini A Prebiotic concept for infant nutrition Acta Pacdiatrica 2003; 92: 64–7.

Boehm G, Lidestri M, Casetta P, Jelinek J, Negretti F, Stahl B, et al. Supplementation of an oligosaccharide mixture to a bovine milk formula increases counts of faecal bifidobacteria in preterm infants. Arch Dis Childh 2002;86:F178–81.

Calder PC. n-3 fatty Acids, Inflammation, and Immunity – relevance to postsurgical and Critically Ill patients. Lipids 2004;39 (12):1147–61.

Chandra R.K. The Relation between Immunology, Nutrition and Disease in Elderiy People. Age and Ageing 1990;19:25–31.

Coyne MJ, Reinap B, Lee MM, Comstock LE. Human symbionts use a host-like pathway for surface fucosylation. Science 2005;307:1778–81.

McCowen K, Bistrian B. Immunonutrition: problematic or problem solving. Am J Clin Nutr 2003; 77:764–70.

Daly J.M., Lirkerman M.D., Goldfine J. et al. Enteral nutrition with supplemental arginine, RNA and omega-3 fatty acids in patients after operation: immunologic, metabolic and clinical outcomes. Surgery 1992;112:56–7.

Dorofeyeva G, Churylina A, Mahmutov R. The experience of using of new generation substitutes of human milk for nutrition of infants uffering from intestinal dysbiosis. The Conference “Food allergy in children:prophylaxis and therapeutic nutrition”; Kyiv; 2005, 10–12.

Dorofeyeva G, Churilina A, Yeroshenko I. et al. Up-to-date view on the rational feeding of infants, suffering from intestinal dysbiosis, using the new generation substitutes of human milk, produced by “Nutricia” company. International Congress “Healthy nutrition, dysbiosis and it prophylaxis with prebiotic-containing products of new generation”; Kyiv; 2003, 21–23.

Drannik G.N. Clinical immunology and allergology. M.: Medical news agency; 2003; 604 p.

Duka KD., Yelchenko SI. Corection of nutritional disorders and immune status in infants in condition of ecological stress. The Conference “Functional nutrition and it influence on immunity and health of infants”; Yalta; 2006, 14–5.

Fanaro S, Boehm G, Garsen J, et al. Galacto-oligosaccharides and long-chain fructo-oligosaccharides as prebiotics in infant formulas: A review. Acta Paediatrica 2005; 94:22–26.

Fanaro S, Chierici R, Guerrini P, Vigi V. Intestinal microflora in early infancy: composition and development. Acta Pediatr 2003;Suppl441:S48–55.

Fedortsiv O.E. The use of formula “Nutrilon” for nurse of children with malnutrition. International Congress “Healthy nutrition, dysbiosis and it prophylaxis with preiotic-containing products of new generation”; Kyiv; 2003, 49–50.

Forchielli ML, Walker WA. The role of gut-associated lymphoid tissues and mucosal defence British J. of Nutr 2005; 93, Suplpl.1: S41–48

Gibson GR, Collins MD. Concept of balanced colonic microbiota, prebiotics, and synbiotics. In: Hanson LA, Yolken RH, editors. Probiotics, other nutritional factors, and intestinal microflora. Nestle Nutrition Workshop Series, no. 42. Philadelphia: Lippincott-Raven Publishers; 1999. p.139–56.

Harmsen HJM, Wildeboer-Veloo ACM, Raangs GC. Analysis of intestinal flora development in breast fed and formula fed infants by using molecular identification and detection methods. Pediatr Gastroenterol Nutr 2000; 30:61–7

Hooper LV, Gordon JL. Commensal host-bacterial relationship in the gut. Science 2001;292:1115–8.

Isolauri E, Sutas Y, Kankaanpaa P, Arvilommi H, Salminen S. Probiotics: effects on immunity. Am J Clin Nutr 2001;73:S44–50.

Klymenko TM, Koroleva GA, Karatay OS, Leshchenko

RI. The influence of formula “Nutrilon with probiotic” on establishment of intestinal microbiota in new born children and infants. International Congress “Healthy nutrition, dysbiosis and it nutritional prophylaxis with prebiotic-containing products of new generation”; Kyiv; 2003, 20–21.

Knol J, Boehm G, Lidestri M, Negretti F, Jelinek J, Agosti M, et al. Increase of faecal bifidobacteria due to dietary oligosaccharides induces a reduction of clinically relevant pathogen germs in the faeces of formulafed preterm infants. Acta Paediatr 2005;94(Suppl 449): 31–3.

Kohler H, McCormick BA, Allan WW. Bacterial-enterocyte crosstalk: cellular mechanisms in health and disease. J Pediatr Gastroenterol Nutr 2003;36:175–85.

Macfarlane GT, Cummings JH. Probiotics, infection and immunity. Curr Opin Infect Dis 2002;15:501–6.

Macpherson AJ, Uhr T. Compartmentalization of the mucosal immune response to commensal intestinal bacteria. Ann N Y Acad Sci 2004;1029:36–43.

Moro G, Arslanoglu S, Stahl B, et al. A mixture of prebiotic oligosaccharides reduces the incidence of atopic dermatitis during the first six months of age. Arh Dis Child 2006;000:1–6 doi: 10.1136

Moro GE, Arslanoglu S. Reproducing the bifidogenic effect of milk in formula-fed infants: Why and how. Acta Paediatrica, 2005; 94:14–17.

Mukvich OM., Ott VD. The influence of formula “Nutrilon” with prebiotics on immunological and cytoprotective processes in children with intestinal dysbiosis. The Conference “Food allergy in children: prophylaxis and therapeutic nutrition”; Kyiv; 2005, 38–44.

Newburg DS, Neubauer SH. Carbohydrates in milks: analysis, quantities and significance. In. Jensen RG, editor. Handbook of milk composition. San Diego: Academic Press; 1995. p 273–349.

Nyankovskyy S, Ivakhnenko O. Immune-response modulating effect of nutrition. Perinatology and pediatrics (Ukr), 2006; 3:97–100.

Nyankovskyy S. Prophylactic and therapeutic nutrition of infants. Lviv: Kvart; 2005, 145 p.

Roberfroid MB, Bornet F, Bouley C, Cummings JH. Colonic microflora: nutrition and health. Nutr Rev 1995; 3: 127–30.

Ott VD, Mukvich EN, Tyshchenko VK. Prebiotics and their role in nutrition of infants. International Congress “Healthy nutrition, dysbiosis and it nutritional prophylaxis with prebiotic-containing products of new generation” Kyiv; 2003, 14–7

Prohorov EV, Ostrovskiy I.M, Akimochkina NA. The state of immunological resistance and colonic flora in children of the first 6 months of life with functional disorders of gastro-intestinal tract. The Conference “Functional nutrition and it influence on immunity and health of infants”; Yalta; 2006, 44–46.

Reznichenko Yu.G., Bessicalo R.I., Reznichenko N.Yu., Matsko O.S. An effectivness of formula feeding with prebiotics for prevention of polimorbidity in children from big industrial city. The Conference “Functional nutrition and it influence on immunity and health of infants”;

Yalta; 2006, 47–8.

Rudloff S, Stefan C, Pohlentz G, Cunz K. Detection of ligands for selectins in the oligosaccharide fraction of human milk. Eur J Nutr 2002;41:85–92.

Salminen S., Isolauri E. Intestinal cilinization, microbiota, and probiotics. J Pediatr. 2006; 149: S115–20.

Satokari RM, Vaughan EE, Fawier, at al. Diversity of Bifidobacterium and Lactobacillus spp. in breast-fed and formula-fed infants as assessed by 16S rDNA sequence differences. Microb Ecol Health Dis 2002; 14:97–105.

Shi HN, Walker A. Bacterial colonization and the development of intestinal defences. Can J Gastroenterol 2004;18:493–500.

Sullivan A, Nord CE. Probiotics and gastrointestinal disease. J Intern Med 2005;257:78–92.

Tissier H. Recherches sur la intestinale normale et pathologiquede nourisson.- Thede de Paris.- 1900

Tyshchenko VA, Bakay NS, Belozerova VL, Velichko EG. An experience of using formula with prebiotic in infant's nutrition. International Congress “Healthy nutrition, dysbiosis and it nutritional prophylaxis with prebiotic-containing products of new generation”; Kyiv; 2003, 17–9.

Weng M., Walker A. Bacterial colonization, probiotics, and clinical disease. J Pediatr 2006;149:S107–114.

Zolotareva SG, Vergiles AK, Lapina IG, et al. Assesment of changes of intestinal biocenosis in children fed with highly-adapted formula with prebiotic “Nutrilon-2”. International Congress “Healthy nutrition, dysbiosis and it prophylaxis with prebiotic-containing products of new generation”; Kyiv; 2003, 49–50.

Downloads

Published

2007-12-30

How to Cite

Nyankovskyy, S., & Ivakhnenko, O. (2007). The influence of oligosaccharide-containing formula feeding on establishment of intestinal biocenosis and protective functions of child’s organism. European Journal of Clinical and Experimental Medicine, 5(4), 380–387. Retrieved from https://journals.ur.edu.pl/ejcem/article/view/13315