Radionuclide evaluation of relationship between the left ventricle pefusion and function and the serum level of brain natriuretic peptide in cases of coronary artery disease

Authors

  • Edyta Matusik Z Katedry i Kliniki Neurologii, Śląskiej Akademii Medycznej, Katowice-Ligota
  • Andrzej Wajgt Z Katedry i Kliniki Neurologii, Śląskiej Akademii Medycznej, Katowice-Ligota
  • Joanna Janowska Katedra i Zakład Patofizjologii, Śląska Akademia Medyczna, Katowice
  • Barbara Zahorska-Markiewicz Katedra i Zakład Patofizjologii, Śląska Akademia Medyczna, Katowice

Keywords:

ischemic stroke, adhesion molecules, sICAM-1, sVCAM-1

Abstract

It exists strong interaction between nervous and immune system during cerebral ischemia. The consequence are the complex interactions which lead to the immune cells migration through the blood-brain barrier. In this barrier crossing adhesion molecules play the crucial role, which soluble forms are releasing into the circulation. The aim of the study was to establish that soluble forms of adhesion molecules correlate with the volume of ischemic region. The study was conducted in 36 patients with ischemic stroke. In the study group (SG) of stroke patients sICAM-1 (soluble intracellular adhesion molecule-1) and sVCAM-1 (soluble vascular cell adhesion molecule-1) levels in the 1st, 5th and 14th day of ischemic stroke were assessed (ELISA). The volume of ischemic focus based on CT scans was assessed in every patient. Significant correlation (r = 0,332; p< 0,05) between initial sICAM-1 level and stroke volume was observed. There were no significant correlation with sICAM-1 levels in the further phase of stroke. sVCAM-1 levels did not correlate significantly with stroke volume. The following conclusion was drawn: The initial level of sICAM-1 may be the indication of the focus volume in ischemic stroke.

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Published

2007-07-30

How to Cite

Matusik, E., Wajgt, A., Janowska, J., & Zahorska-Markiewicz, B. (2007). Radionuclide evaluation of relationship between the left ventricle pefusion and function and the serum level of brain natriuretic peptide in cases of coronary artery disease. European Journal of Clinical and Experimental Medicine, 5(2), 121–126. Retrieved from https://journals.ur.edu.pl/ejcem/article/view/13336

Issue

Vol. 5 No. 2 (2007): Medical Journal of the Rzeszow University

Section

ORIGINAL PAPERS

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Copyright (c) 2007 Medical Journal of the Rzeszow University

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