Plants – a source of therapeutic material?
DOI:
https://doi.org/10.15584/ejcem.2018.1.5Keywords:
plants, natural products, drug, therapeutic materialAbstract
Introduction. The use of plants with therapeutic or medicinal properties is as ancient as human civilization and for many years prior to the 20th century, plants and animal products were the main source of therapeutic medicinal drugs.
Aim. The discovery of new plant-derived drugs continues to be an active field of research in medical science today. The aim of this article is to describe several main classes of natural products currently under investigation.
Material and methods. Analysis of literature.
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References
Habtemariam S, Lentini G. Plant-derived anticancer agents: lessons from the pharmacology of geniposide and its aglycone, genipin. Biomedicines. 2018;6(2). doi: 10.3390/biomedicines6020039.
Manh Hung LV, Song YW, Cho SK. Effects of the combination of gliotoxin and adriamycin on the adriamycin-resistant non-small-cell lung cancer A549 cell line. Mar Drugs. 2018;16(4). doi: 10.3390/md16040105.
Moga MA, Dimienescu OG, Arvătescu CA, Ifteni P, Pleş L. Anticancer activity of toxins from bee and snake venom-an overview on ovarian cancer. Molecules. 2018;23(3). doi: 10.3390/molecules23030692.
Abdel-Kahaar E, Zolk O. Prescribing of anticancer drugs in renal impairment: why can't we do better? Naunyn Schmiedebergs Arch Pharmacol. 2018;391(2):107-109.
Liu Y, Liu K, Li X, et al. A novel self-assembled nanoparticle platform based on pectin-eight-arm polyethylene glycol-drug conjugates for co-delivery of anticancer drugs. Mater Sci Eng C Mater Biol Appl. 2018;86:28-41.
Kingston DG, Gerhart BB, Ionescu F, Mangino MM, Sami SM. Plant anticancer agents V: new bisindole alkaloids from Tabernaemontana johnstonii stem bark. J Pharm Sci. 1978;67(2):249-251.
Umsumarng S, Pitchakarn P, Yodkeeree S, et al. Modulation of P-glycoprotein by Stemona alkaloids in human multidrug resistance leukemic cells and structural relationships. Phytomedicine. 2017;34:182-190.
Croaker A, King GJ, Pyne JH, Anoopkumar-Dukie S, Liu L. Sanguinaria canadensis: traditional medicine, phytochemical composition, biological activities and current uses. Int J Mol Sci. 2016;17(9).
Umsumarng S, Pitchakarn P, Yodkeeree S, et al. Modulation of P-glycoprotein by Stemona alkaloids in human multidrug resistance leukemic cells and structural relationships. Phytomedicine. 2017;34:182-190.
Tian Y, Zhang C, Guo M. Comparative study on alkaloids and their anti-proliferative activities from three Zanthoxylum species. BMC Complement Altern Med. 2017;17(1):460.
Plodek A, Bracher F. New perspectives in the chemistry of Marine Pyridoacridine alkaloids. Mar Drugs. 2016;14(2).
Fandy TE, Abdallah I, Khayat M, Colby DA, Hassan HE. In vitro characterization of transport and metabolism of the alkaloids: vincamine, vinpocetine and eburnamonine. Cancer Chemother Pharmacol. 2016;77(2):259-267.
Wang C, Zhang Z, Wang Y, He X. Cytotoxic indole alkaloids against human leukemia cell lines from the toxic plant Peganum harmala. Toxins (Basel). 2015;7(11):4507-4518.
El-Readi MZ, Eid S, Ashour ML, Tahrani A, Wink M. Modulation of multidrug resistance in cancer cells by chelidonine and Chelidonium majus alkaloids. Phytomedicine. 2013;20(3-4):282-294.
Zheng X, Aly NA, Zhou Y, et al. A structural examination and collision cross section database for over 500 metabolites and xenobiotics using drift tube ion mobility spectrometry. Chem Sci. 2017;8(11):7724-7736.
Waladkhani AR, Clemens MR. Effect of dietary phytochemicals on cancer development (review). Int J Mol Med. 1998;1(4):747-753.
Fröhlich RH, Kunze M, Kiefer I. Cancer preventive value of natural, non-nutritive food constituents. Acta Med Austriaca. 1997;24(3):108-113.
Gadducci A, Guerrieri ME, Cosio S, et al. Rates, sites and times of recurrence and clinical outcome of endometrial cancer patients with histologically-positive nodes: an italian two-center retrospective study. Anticancer Res. 2018;38(3):1695-1703.
Renouard S, Corbin C, Drouet S, et al. Investigation of Linum flavum (L.) hairy root cultures for the production of anticancer Aryltetralin lignans. Int J Mol Sci. 2018;19(4).
Melo MNO, Oliveira AP, Wiecikowski AF, et al. Phenolic compounds from Viscum album tinctures enhanced antitumor activity in melanoma murine cancer cells. Saudi Pharm J. 2018;26(3):311-322.
Ionkova I. Anticancer lignans- from discovery to biotechnology. Mini Rev Med Chem. 2011;11(10):843-856.
Botta B, Delle Monache G, Misiti D, Vitali A, Zappia G. Aryltetralin lignans: chemistry, pharmacology and biotransformations. Curr Med Chem. 2001;8(11):1363-1381.
Ivanova D, Zhelev Z, Lazarova D, Getsov P, Bakalova R, Aoki I. Vitamins C and K3: A powerful redox system for sensitizing leukemia lymphocytes to everolimus and barasertib. Anticancer Res. 2018;38(3):1407-1414.
Abdel-Hamid NI, El-Azab MF, Moustafa YM. Macrolide antibiotics differentially influence human HepG2 cytotoxicity and modulate intrinsic/extrinsic apoptotic pathways in rat hepatocellular carcinoma model. Naunyn Schmiedebergs Arch Pharmacol. 2017;390(4):379-395.
Qi Y, Ma S. The medicinal potential of promising marine macrolides with anticancer activity. Chem Med Chem. 2011;6(3):399-409.
Shi QW, Li LG, Wang YF, Huo CH, Zhang ML. The recent research progress of chemistry of marine natural products. Yao Xue Xue Bao. 2010;45(10):1212-1223.
Aygün A, Pindur U. Chemistry and biology of new marine alkaloids from the indole and annelated indole series. Curr Med Chem. 2003;10(13):1113-1127.
Saad HE, el-Sharkawy SH, Shier WT. Biological activities of pyrrolidinoindoline alkaloids from Calycodendron milnei. Planta Med. 1995;61(4):313-316.
Floros DJ, Jensen PR, Dorrestein PC, Koyama N. A metabolomics guided exploration of marine natural product chemical space. Metabolomics. 2016;12(9).
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