Fundamentals of the use of Berberis as a medicinal plant
DOI:
https://doi.org/10.15584/ejcem.2018.1.7Keywords:
medicinal plants, phythotherapy, BerberisAbstract
Introduction. The daily use of medicinal plants has increased in recent years. The study of drugs of natural origin as an academic discipline and its applications in healthcare has changed remarkably but still focus on the quality of products and the development of new medicines.
Aim. This study covers all fundamental aspects of pharmacognosy as well as topics relating to the therapeutic use of plant drugs known as phythotherapy. The purpose of the study was to review the literature about the use of Berberis.
Material and methods. We reviewed the literature regarding the use of Berberis published between 1933 and 2018. We found more than 500 articles studying the properties of Berberis for digestive disorders, antibacterial, antidiabetic, hypotensive effects, anti-inflammatory effects, cholesterol regulation, cardiovascular disease, hyperlipidemia, cerebral ischemia trauma, mental disease, Alzheimer disease and osteoporosis. Our review includes recent studies regarding chemical composition and medicinal outcomes of Berberis.
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References
Habtemariam S. The therapeutic potential of berberis darwinii stem-bark: quantification of berberine and in vitro evidence for Alzheimer's disease therapy. Nat Prod Commun. 2011;6(8):1089-1090.
Yang J, Zhao P, Wan D, et al. Antidiabetic effect of methanolic extract from berberis julianae schneid. Via activation of AMP-activated protein kinase in type 2 diabetic mice. Evid Based Complement Alternat Med. 2014;2014:106206.
Zhang CR, Schutzki RE, Nair MG. Antioxidant and anti-inflammatory compounds in the popular landscape plant Berberis thunbergii var. atropurpurea. Nat Prod Commun. 2013;8(2):165-168.
Charehsaz M, Sipahi H, Celep E, et al. The fruit extract of berberis crataegina DC: Exerts potent antioxidant activity and protects DNA integrity. Daru. 2015;23(1):24.
Gulsoy S, Ozkan G, Ozkan K. Mineral elements, phenolics and organic acids of leaves and fruits from Berberis crataegina DC. Asian J Chem. 2011;23(7):3071.
Hussaini FA, Shoeb A. Isoquinoline derived alkaloids from berberis chitria. Phytochemistry. 1985;24(3):633.
Jia XJ, Li X, Wang F, Liu HQ, Zhang DJ, Chen Y. Berbamine exerts anti-inflammatory effects via inhibition of NF-κB and MAPK signaling pathways. Cell Physiol Biochem. 2017;41(6):2307-2318.
Nimisha, Rizvi DA, Fatima Z, Neema, Kaur CD. Antipsoriatic and anti-inflammatory studies of berberis aristata extract loaded nanovesicular gels. Pharmacogn Mag. 2017;13(3):587-594.
Kumar R, Gupta YK, Singh S. Anti-inflammatory and anti-granuloma activity of berberis aristata DC. in experimental models of inflammation. Indian J Pharmacol. 2016;48(2):155-161.
Hashmi K, Hafiz A. In vivo antibacterial activity of Berberis asiatica. J Pak Med Assoc. 1986;36(1):5-7.
Manosalva L, Mutis A, Urzúa A, Fajardo V, Quiroz A. Antibacterial Activity of Alkaloid Fractions from Berberis microphylla G. Forst and Study of Synergism with Ampicillin and Cephalothin. Molecules. 2016;21(1):76.
Ashraf H, Heidari R, Nejati V. Antihyperglycemic and antihyperlipidemic effects of fruit aqueous extract of berberis integerrima Bge. in streptozotocin-induced diabetic rats. Iran J Pharm Res. 2014;13(4):1313-1318.
Derosa G, Bonaventura A, Bianchi L, et al. Berberis aristata/Silybum marianum fixed combination on lipid profile and insulin secretion in dyslipidemic patients. Expert Opin Biol Ther. 2013;13(11):1495-1506.
Wang H, Zhu C, Ying Y, Luo L, Huang D, Luo Z. Metformin and berberine, two versatile drugs in treatment of common metabolic diseases. Oncotarget. 2017;9(11):10135-10146.
Abushouk AI, Abdo Salem AM, Abdel-Daim MM. Berberis vulgaris for cardiovascular disorders: a scoping literature review. Iran J Basic Med Sci. 2017;20:503-510.
Pai KS, Srilatha P, Suryakant K, et al. Anticancer activity of Berberis aristata in Ehrlich ascites carcinoma-bearing mice: a preliminary study. Pharm Biol. 2012;50(3):270-277.
Qadir SA, Kwon MC, Han JG, et al. Effect of different extraction protocols on anticancer and antioxidant activities of berberis koreana bark extracts. J Biosci Bioeng. 2009;107(3):331-338.
Kamrani Rad SZ, Rameshrad M, Hosseinzadeh H. Toxicology effects of Berberis vulgaris (barberry) and its active constituent, berberine: a review. Iran J Basic Med Sci. 2017;20:516-529.
Khan I, Qayum A, Qureshi Z. Study of the hypotensive action of berbamine, an alkaloid isolated from berberis lycium. Life Sci. 1969;8(17):993-1001.
Tomosaka H, Chin Y, Salim AA, Keller WJ, Chai H, Kinghorn AD. Antioxidant and cytoprotective compounds from Berberis vulgaris (Barberry). Phytother Res. 2008;22:979-981.
Khan I, Najeebullah S, Ali M, Khan Shinwari Z. Phytopharmacological and ethnomedicinal uses of the Genus Berberis (Berberidaceae): A review. Trop J Pharm Res. 2016;15(9):2047-2057.
Mokhber-Dezfuli N, Saeidnia S, Gohari AR, Kurepaz-Mahmoodabadi M. Phytochemistry and pharmacology of berberis species. Pharmacogn Rev. 2014;8(15):8-15.
Srivastava S, Srivastava M, Misra A, Pandey G, Rawat AKS. A review on biological and chemical diversity in Berberis (Berberidaceae). EXCLI J. 2015;14:247-267.
Bhardwaj D, Kaushik N. Phytochemical and pharmacological studies in genus berberis. Pharmacogn Rev. 2012;11(4):523-542.
Rahaman MS, Chaudhary MA, Ahmad B, Alamgeer A. Rationalization of traditional uses of berberis lycium in gastrointestinal disorders. Br J Med Med Res. 2013;3(4):868-879.
Bakht J, Iftikhar Z, Shafi M, Iqbal A. Report - Screening of medicinally important berberis lyceum for their antimicrobial activity by disc diffusion assay. Pak J Pharm Sci. 2017;30(5):1783-1789.
Imenshahidi M, Hosseinzadeh H. Berberis vulgaris and berberine: an update review. Phytother Res. 2016;30(11):1745-1764.
Rahimi-Madiseh M, Lorigoini Z, Zamani-Gharaghoshi H, Rafieian-Kopaei M. Berberis vulgaris: specifications and traditional uses. Iran J Basic Med Sci. 2017;20(5):569-587.
Imanshahidi M, Hosseinzadeh H. Pharmacological and therapeutic effects of berberis vulgaris and its active constituent, berberine. Phytother Res, 2008;22(8):999-1012.
Arayne MS, Sultana N, Bahadur SS. The berberis story: Berberis vulgaris in therapeutics. Pak J Pharm Sci. 2007;20(1):83-92.
Di Pierro F, Putignano P, Villanova N. Retrospective analysis of the effects of a highly standardized mixture of Berberis aristata, Silybum marianum, and monacolins K and KA in diabetic patients with dyslipidemia. Acta Biomed. 2018;88(4):462-469.
Fallah H, Akbari H, Abolhassani M, Mohammadi A, Gholamhosseinian A. Berberis integerrima ameliorates insulin resistance in high- fructose-fed insulin-resistant rats. Iran J Basic Med Sci. 2017;20(10):1093-1101.
Guarino G, Strollo F, Carbone L, et al. Bioimpedance analysis, metabolic effects and safety of the association Berberis aristata/Bilybum marianum: a 52-week double-blind, placebo-controlled study in obese patients with type 2 diabetes. J Biol Regul Homeost Agents. 2017;31(2):495-502.
Fatehi M, Saleh TM, Fatehi-Hassanabad Z, Farrokhfal K, Jafarzadeh M, Davodi S. A pharmacological study on Berberis vulgaris fruit extract. J Ethnopharmacol. 2005;102(1):46-52.
Alamgeer, Uttra AM, Hasan UH. Anti-arthritic activity of aqueous-methanolic extract and various fractions of Berberis orthobotrys Bien ex Aitch. BMC Complement Altern Med. 2017;17(1):371.
Sengupta P, Raman S, Chowdhury R, et al. Evaluation of apoptosis and autophagy inducing potential of berberis aristata, azadirachta indica, and their synergistic combinations in parental and resistant human osteosarcoma cells. Front Oncol. 2017;7:296.
Zovko Končić M, Kremer D, Karlović K, Kosalec I. Evaluation of antioxidant activities and phenolic content of Berberis vulgaris L. and Berberis croatica Horvat. Food Chem Toxicol. 2010;48(8-9):2176-2180.
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