The comorbidity of papillary thyroid carcinoma and the primary hyperparathyroidism
DOI:
https://doi.org/10.15584/ejcem.2018.2.4Keywords:
thyroid carcinoma, primary hyperparathyroidism, parathyroid adenomaAbstract
Introduction. The prevalence of papillary thyroid carcinoma (PTC) in patients with primary hyperparathyroidism (PHPT) is low, it can be estimated around 2 to 4%. For unknown reasons it is higher than the prevalence of PTC in the overall population. The authors analyse the comorbidity of PTC with PHPT on patients treated in their institution.
Material and methods. The analysis covered medical records of 885 patients subject to the thyroid resection procedure and 95 patients operated for PHPT, the procedures were performed in years 2005-2014.
Results. In the above-mentioned period there were 121 patients operated due to a malignant thyroid tumour and there were 95 patients that had surgery for PHPT. There were 4 cases of comorbidity of PHPT with papillary thyroid cancer. Prevalence of PTC at the patients with PHPT was 4.2%. In two out of the four cases, both diseases were diagnosed prior to the procedure and the single appropriate surgery i.e. total thyroidectomy and excision of parathyroid adenoma was performed. In the other two cases false positive localisation of parathyroid adenoma occurred due to metastatic cancerous lesions in cervical lymph nodes. The diagnosis of PTC was made postoperatively based on surgical specimen examination. Second surgical procedure appropriate for this diagnosis was necessary in both cases.
Conclusion. The comorbidity of PHPT and PTC is clinically important and should be taken into account in the case of patients with PHPT and thyroid tumours. There is the possibility of false positive localization of parathyroid adenoma in the case of metastatic cancerous lesions in cervical lymph nodes.
Downloads
References
Bilezikian JP, Silverberg SJ. Asymptomatic primary hyperparathyroidism. N Engl J Med. 2004;350(17):1746-1751. doi:10.1056/NEJMcp032200
Friedrich J, Krause U, Olbricht T, Eigler FW. Simultaneous interventions of the thyroid gland in primary hyperparathyroidism (pHPT). Zentralbl Chir. 1995;120(1):43-46.
Adler JT, Chen H, Schaefer S, Sippel RS. Does Routine Use of Ultrasound Result in Additional Thyroid Procedures in Patients with Primary Hyperparathyroidism? J Am Coll Surg. 2010;211(4):536-539. doi:10.1016/j.jamcollsurg.2010.05.015
Regal M, Paramo C, Luna Cano R, et al. Coexistence of primary hyperparathyroidism and thyroid disease. J Endocrinol Invest. 1999;22(3):191-197.
Attie JN, Vardhan R. Association of hyperparathyroidism with nonmedullary thyroid carcinoma: review of 31 cases. Head Neck. 1993;15(1):20-23.
Kissin M, Bakst H. Co-existing myxedema and hyperparathyroidism: case report. J Clin Endocrinol. 1947;7(2):152-158. doi:10.1210/jcem-7-2-152
Beus KS, Stack BC. Synchronous thyroid pathology in patients presenting with primary hyperparathyroidism. Am J Otolaryngol. 2004;25(5):308-312.
Vysetti S, Sridhar P, Theckedath B, Gilden JL, Morawiecki P. Synchronous Papillary Thyroid Carcinoma and Primary Hyperparathyroidism: Diagnosis and Management Issues. Hosp Pract. 2012;40(4):16-19. doi:10.3810/hp.2012.10.998
Kwee HWS, Marapin V, Verkeyn JMA, van Nederveen FH. A man with thyroid abnormalities: ectopic parathyroid adenoma and multifocal thyroid carcinoma. Ned Tijdschr Geneeskd. 2012;156(41):A5146.
Javadi H, Jallalat S, Farrokhi S, et al. Concurrent papillary thyroid cancer and parathyroid adenoma as a rare condition: a case report. Nucl Med Rev Cent East Eur. 2012;15(2):153-155.
Mahmoodzadeh H, Harirchi I, Hassan Esfehani M, Alibakhshi A. Papillary thyroid carcinoma associated with parathyroid adenoma. Acta Med Iran. 2012;50(5):353-354.
Ghorra C, Rizk H, Abi Hachem R, Tannoury J, Abboud B. Association of parathyroid pathology with well-differentiated thyroid carcinoma. Presse Med. 2012;41(6):e265-e271. doi:10.1016/J.LPM.2011.12.016
Baumann K, Weichert J, Krokowski M, Diedrich K, Banz-Jansen C. Coexistent parathyroid adenoma and thyroid papillary carcinoma in pregnancy. Arch Gynecol Obstet. 2011;284(1):91-94. doi:10.1007/s00404-011-1903-0
Rajewska J, Lacka K, Stawny B, Majewski P. Primary hyperparathyroidism in patient with thyroid papillary cancer--case report. Pol Merkur Lekarski. 2010;29(174):373-376.
Chaychi L, Belbruno K, Golding A, Memoli V. Unusual Manifestation of Parathyroid Carcinoma in the Setting of Papillary Thyroid Cancer. Endocr Pract. 2010;16(4):664-668. doi:10.4158/EP10061.CR
Alavi MS, Azarpira N, Mojallal M. Incidental finding of bilateral papillary thyroid carcinoma in a patient with primary hyperparathyroidism. Hell J Nucl Med. 2010;13(1):56-58.
Iakovou IP, Konstantinidis IE, Chrisoulidou AI, Doumas AS. Synchronous parathyroid adenoma and thyroid papillary carcinoma: a case report. Cases J. 2009;2(1):9121. doi:10.1186/1757-1626-2-9121
Turki ZM, Hajri H, Zrig N, Kourda N, Ferjaoui M, Ben Slama C. Toxic nodular goitre associated with papillary thyroid carcinoma and primary hyperparathyroidism. Rev Laryngol Otol Rhinol (Bord). 2006;127(4):239-242.
Meshikhes A-WN, Butt SA, Al-Saihati BA. Combined parathyroid adenoma and an occult papillary carcinoma. Saudi Med J. 2004;25(11):1707-1710.
Krause U, Benker G, Reiners C, Rudy T. Coincidence of hyperparathyroidism and thyroid gland cancer. Langenbecks Arch Chir Suppl II Verh Dtsch Ges Chir. 1990:983-985.
De Menezes Montenegro FL, Lourenço DM, Tavares MR, et al. Total parathyroidectomy in a large cohort of cases with hyperparathyroidism associated with multiple endocrine neoplasia type 1: experience from a single academic center. Clinics. 2012;67(1):131-139. doi:10.6061/clinics/2012(Sup01)22.
Leitha T, Staudenherz A. Concomitant Hyperparathyroidism and Nonmedullary Thyroid Cancer, with a Review of the Literature. Clin Nucl Med. 2003;28(2):113-117. doi: 10.1097/01.RLU.0000048680.30820.52
Krause UC, Friedrich JH, Olbricht T, Metz K. Association of primary hyperparathyroidism and non-medullary thyroid cancer. Eur J Surg. 1996;162(9):685-689.
Lehwald N, Cupisti K, Krausch M, Ahrazoglu M, Raffel A, Knoefel WT. Coincidence of Primary Hyperparathyroidism and Nonmedullary Thyroid Carcinoma. Horm Metab Res. 2013;45(09):660-663. doi:10.1055/s-0033-1345184
Fedorak IJ, Salti G, Fulton N, Schark C, Straus FH 2nd, Kaplan EL. Increased incidence of thyroid cancer in patients with primary hyperparathyroidism: a continuing dilemma. Am Surg. 1994;60(6):427-431.
Masatsugu T, Yamashita H, Noguchi S, et al. Thyroid evaluation in patients with primary hyperparathyroidism. Endocr J. 2005;52(2):177-182.
Lachungpa T, Sarawagi R, Chakkalakkoombil SV, Jayamohan AE. Imaging features of primary hyperparathyroidism. BMJ Case Rep. 2014;2014. doi:10.1136/bcr-2013-203521
Weiss DM, Chen H. Role of cervical ultrasound in detecting thyroid pathology in primary hyperparathyroidism. J Surg Res. 2014;190(2):575-578. doi:10.1016/j.jss.2014.03.038
Greilsamer T, Blanchard C, Christou N, et al. Management of thyroid nodules incidentally discovered on MIBI scanning for primary hyperparathyroidism. Langenbeck’s Arch Surg. 2015;400(3):313-318. doi:10.1007/s00423-015-1286-y
Arciero CA, Shiue ZS, Gates JD, et al. Preoperative Thyroid Ultrasound Is Indicated in Patients Undergoing Parathyroidectomy for Primary Hyperparathyroidism. J Cancer. 2012;3:1-6.
Whitcroft KL, Sharma A. Sestamibi scintigraphy for parathyroid localisation: a reminder of the dangers of false positives. BMJ Case Reports. 2014;2014. doi:10.1136/bcr-2013-203225
Onkendi EO, Richards ML, Thompson GB, Farley DR, Peller PJ, Grant CS. Thyroid Cancer Detection with Dual-isotope Parathyroid Scintigraphy in Primary Hyperparathyroidism. Ann Surg Oncol. 2012;19(5):1446-1452. doi:10.1245/s10434-012-2282-x
Lee J, Obrzut S, Yi E, Deftos L, Bouvet M. Incidental Finding of Metastatic Papillary Thyroid Carcinoma in a Patient with Primary Hyperparathyroidism. Endocr Pract. 2007;13(4):380-383. doi:10.4158/EP.13.4.380
Polyzos SA, Anastasilakis AD, Iakovou IP, Partsalidou V. Primary hyperparathyroidism and incidental multifocal metastatic papillary thyroid carcinoma in a man. Arq Bras Endocrinol Metabol. 2010;54(6):578-582.
Yamamoto T, Tatemoto Y, Hibi Y, Ohno A, Osaki T. Thyroid Carcinomas Found Incidentally in the Cervical Lymph Nodes: Do They Arise From Heterotopic Thyroid Tissues? J Oral Maxillofac Surg. 2008;66(12):2566-2576. doi:10.1016/J.JOMS.2008.06.025
Michaud L, Balogova S, Burgess A, et al. A Pilot Comparison of 18F-fluorocholine PET/CT, Ultrasonography and 123I/99mTc-sestaMIBI Dual-Phase Dual-Isotope Scintigraphy in the Preoperative Localization of Hyperfunctioning Parathyroid Glands in Primary or Secondary Hyperparathyroidism: Influence of. Medicine (Baltimore). 2015;94(41):e1701.
Li Q, Pan J, Luo Q, Wang Y, Bao Y, Jia W. The key role of 99mTc-MIBI SPECT/CT in the diagnosis of parathyroid adenoma: a case report. Arch Endocrinol Metab. 2015;59:265-269.
Nagar S, Walker DD, Embia O, Kaplan EL, Grogan RH, Angelos P. A novel technique to improve the diagnostic yield of negative sestamibi scans. Surgery. 2014;156(3):584-590. doi:10.1016/j.surg.2014.05.020
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2018 European Journal of Clinical and Experimental Medicine
This work is licensed under a Creative Commons Attribution 4.0 International License.
Our open access policy is in accordance with the Budapest Open Access Initiative (BOAI) definition: this means that articles have free availability on the public Internet, permitting any users to read, download, copy, distribute, print, search, or link to the full texts of these articles, crawl them for indexing, pass them as data to software, or use them for any other lawful purpose, without financial, legal, or technical barriers other than those inseparable from having access to the Internet itself.
All articles are published with free open access under the CC-BY Creative Commons attribution license (the current version is CC-BY, version 4.0). If you submit your paper for publication by the Eur J Clin Exp Med, you agree to have the CC-BY license applied to your work. Under this Open Access license, you, as the author, agree that anyone may download and read the paper for free. In addition, the article may be reused and quoted provided that the original published version is cited. This facilitates freedom in re-use and also ensures that Eur J Clin Exp Med content can be mined without barriers for the research needs.
