Myositis as a manifestation of neoplastic disease – report of the three cases
Keywords:
inflammatory myopathies, neoplastic disease, paraneoplastic syndromesAbstract
Inflammatory myopathies are classified as paraneoplastic syndromes. The most common associated are ovary, breast, lung, gastrointestinal and renal – cancers, haematological malignances, melanoma and widely spread in Asian nasopharyngeal carcinoma. Pathogenetic mechanism responsible for the coexistence of these diseases is unknown. Antigenic similarity between the regenerating myofibroblasts and some population of cancer cells may play an important role.
We described a case of dermatomyositis in a 74-years old man with concomitant bladder tumor and small-cell lung cancer and two cases of polimyositis: in 53-years old man in whom diagnosed testicular neoplasm and in 63-years old woman in whom ovarian tumor and myelodysplastic syndrome were detected during the observation. In all described cases we observed turbulent onset of disease, in two cases severe muscle pain, difficulty swallowing, and lack of response to therapy. These symptoms are classified as risk factors for cancer.
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