Cytotoxic and anticancer activity of Moringa oleifera
DOI:
https://doi.org/10.15584/ejcem.2020.3.9Keywords:
anticancer activity, cytotoxic activity, Moringa oleiferaAbstract
Introduction. Given its very strong antioxidant properties, Moringa oleifera is particularly noteworthy among medicinal plants. The high contents antioxidants in the M. oleifera determining her antioxidant activities deciding for very important anticancer properties.
Aim. The aim of the paper is to provide an overview of the cytotoxic and anticancer activity of Moringa oleifera.
Material and methods. This review was performed based systematic analysis of literature.
Analysis of the literature. The results of scientific research conducted in vitro indicate that extracts from Moringa oleifera significantly affect the development of human cancer cells such as myeloma, leukemia, cervix, breast, colon, lung, liver, neuroblastoma, pancreas, colorectal, epidermoid, oral, ovarian, muscular, prostate, skin.
Conclusion. This indicates Moringa oleifera as that they may be used as a therapeutic agent to support oncological therapies.
Downloads
References
Maciąg M, Szklarczyk M. Rośliny w medycynie, farmacji i przemyśle. Sentkowska A, Dróżdż P, Pyrzyńska K, eds. Napary ziołowe jako źródło związków polifenolowych. Wyd. Naukowe TYGIEL. 2016;111-118.
Fahey J. Moringa oleifera: A Review of the Medical Evidence for Its Nutritional, Therapeutic, and Prophylactic Properties. Part 1. Trees for Life Journal. 2005;1;5.
Prabhu K, Murugan K, Nareshkumar A, Ramasubramanian N, Bragadeeswaran S. Larvicidal and repellent potential of Moringa oleifera against malarial vector, Anopheles stephensi Liston. Asian Pacific J Trop Biomed. 2011;1(2):124-129. doi: 10.1016/S2221-1691(11)60009-9
Afolabi AO, Aderoju HA, Alagbonsi I.A. Effects of Methanolic Extract of Moringa Oleifera leaves on semen and biochemical parameters in cryptorchid rats. Afr J Tradit Complement Altern Med. 2013;10(5):230-235. doi: 10.4314/ajtcam.v10i5.3
Gopalakrishnan L, Doriya K, Kumar DS. Moringa oleifera: A review on nutritive importance and its medicinal application. Food Science and Human Wellness. 2016; 5(2):49-56. doi.org/10.1016/j.fshw.2016.04.001
Siddhuraju P, Becker K. Antioxidant properties of various solvent extracts of total phenolic constituents from three different agroclimatic origins of drumstick tree (Moringa oleifera Lam.) leaves. J Agric Food Chem. 2003;51(8):2144-55. doi: 10.1021/jf020444+
Amaglo NK, Bennett RN, Curto RB, et al. Profiling selected phytochemicals and nutrients in different tissues of the multipurpose tree Moringa oleifera L., grown in Ghana. Food Chem. 2010;122:1047-1054. doi : 10.1016/j.foodchem.2010.03.073
Tesfay SZ, Bertling I, Odindo AO, Workneh TS, Mathaba N. Levels of anti-oxidants in different parts of Meringa (Moringa oleifera) seedling. Afr J Agric Res. 2011;6:5123-5132. http://www.academicjournals.org/AJAR
Ghazali HM, Mohammed AS. Nuts and seeds in health and disease prevention. Preedy V, Watson Roland, eds. Elsevier, 2011;1-1226.
Pakade V, Cukrowska E, Chimuka L. Comparison of antioxidant activity of Moringa oleifera and selected vegetables in South Africa. S Afr J Sci. 2013;109(3/4):154-155. http://dx.doi.org/10.1590/ sajs.2013/1154
Abdull Razis AF, Ibrahim MD, Kntayya SB. Health benefit of Moringa oleifera. Asian Pac J Cancer Pre., 2014;20:8571-8576. doi:10.7314/apjcp.2014.15.20.8571
Elangovan M, Dhanarajan MS, Rajalakshmi A, Jayachitra A, Pardhasaradhi M, Bhogireddy N. Analysis of phytochemicals, antibacterial and antioxidant activities of Moringa oleifera Lam. leaf extract- an in vitro study. Int J Drug Dev Res. 2014;6(4):173-180.
Wright RJ, Lee KS, Hyacinth HI , et al.. IDAn investigation of the antioxidant capacity in extracts from Moringa oleifera plants grown in Jamaica. Plants. 2017;6(4):48. doi:10.3390/plants6040048
Dhakad AK, Ikram M, Sharma S, Khan S, Pandey VV, Singh A. Biological, nutritional, and therapeutic significance of Moringa oleifera Lam. Phytother Res. 2019;33(11):2870-2903. doi: 10.1002/ptr.6475
Peixoto JRO, Silva GC, Costa RA, Fontenelle JLS, Vieira GHF, Filho AAF, dos Fernandes Vieira RHS. In vitro antibacterial effect of aqueous and ethanolic Moringa leaf extracts. Asian Pac J Trop Med. 2011;4(3):201-204. doi.org/10.1016/S1995-7645(11)60069-2
Jaiswal D, Rai PK, Mehta S, Chatterji S, Shukla S, Rai DK, Sharma G, Sharma B, Khair S, Watal G. Role of Moringa oleifera in regulation of diabetes-induced oxidative stress. Asian Pac J Trop Med. 2013;6(6):426-432. doi: 10.1016/S1995-7645(13)60068-1
Waterman C, Cheng DM, Rojas-Silva P Poulev A, Dreifus J, Lila MA, Raskin I. Stable, water extractable isothiocyanates from Moringa oleifera leaves attenuate inflammation in vitro. Phytochem. 2014;103:114-122. doi: 10.1016/j.phytochem.2014.03.028
Singh A, Dayal R, Ojha RP, Mishra KP. Promising role of Moringa oleifera (Lam.) in improving radiotherapy: An overview. J Innovations Pharm Biol Sci. 2015;2:182-192.
Fitriana WD, Ersam T, Shimizu K, Fatmawati S. Antioxidant activity of Moringa oleifera extracts. Indionesian J Chem. 2016;16(3):297-301. doi.org/10.22146/ijc.21145
Karim NA, Ibrahim MD, Kntayya SB, Rukayadi Y, Hamid HA, Razis AF. Moringa oleifera Lam: Targeting Chemoprevention. Asian Pac J Cancer Prev. 2016;17(8):3675-3686.
Vergara-Jimenez M, Almatrafi MM, Fernandez ML. Bioactive components in Moringa oleifera leaves protect against chronic disease. Antioxidants (Basel). 2017;6(4):91. doi: 10.3390/antiox6040091
Kou X, Li B, Olayanju JB, Drake JM, Chen N. Nutraceutical or pharmacological potential of Moringa oleifera Lam. Nutrients. 2018;10(3):343. doi: 10.3390/nu10030343
Xu YB, Chen GL, Guo MQ. Antioxidant and Anti-Inflammatory Activities of the Crude Extracts of Moringa oleifera from Kenya and Their Correlations with Flavonoids Antioxidants (Basel). 2019; 8(8): 296. doi: 10.3390/antiox808029
Guy M, John A H. Apoptosis and cancer chemotherapy. Cell Tissue Resh. 2000; 301: 143-152.
Ghobrial IM, Witzig TE, Adjei AA. Targeting apoptosis pathways in cancer therapy. Cancer J Clin. 2005; 55:178-194.
Parvathy MVS, Umamaheshwari A. Cytotoxic effect of Moringa oleifera leaf extracts on human multiple myeloma cell lines. Trends Med Res. 2007;2(1):44-50. doi: 10.3923/tmr.2007.44.50
Khalafalla M, Abdellatef E, Dafalla H, et al. Active principle from Moringa oleifera Lam leaves effective against two leukemias and a hepatocarcinoma. Afr J Biot. 2011;9:8467-8471.
Varalakshmi K, Nair S. Anticancer, cytotoxic potential of Moringa oleifera extracts on HeLa cell Line. J Nat Pharm. 2011;2(3):138-138. doi: 10.4103/2229-5119.86260
Sreelatha SA, Jeyachitra B, Padma PR. Antiproliferation and induction of apoptosis by Moringa oleifera leaf extraction human cancer cells. Food Chem Toxicol. 2011;49(6):1270-1275. doi: 10.1016/j.fct.2011.03.006.
Shaban A, Mishra G M, Nautiyal R, et al. In vitro cytotoxicity of Moringa oleifera against different human cancer cell lines. Asian J Pharm Clin Res. 2012;5(4):271–272.
Tiloke C, Phulukdaree A, Chuturgoon AA. The antiproliferative effect of Moringa oleifera crude aqueous leaf extract on cancerous human alveolar epithelial cells. BMC Compl and Altern Med. 2013;13:226-234. doi: 10.1186/1472-6882-13-226
Berkovich L, Earon G, Ron I, Rimmon A, Vexler A, Lev-Ari S. Moringa Oleifera aqueous leaf extract down-regulates nuclear factor-kappaB and increases cytotoxic effect of chemotherapy in pancreatic cancer cells. BMC Complement Altern Med. 2013;13:212. doi: 10.1186/1472-6882-13-212
Charoensin S. Antioxidant and anticancer activities of Moringa oleifera leaves. J Med Plants Res. 2014;8(7):318-325 doi: 10.5897/JMPR2013.5353
Jung IL. Soluble Extract from Moringa oleifera Leaves with a New Anticancer Activity. PLoS ONE. 2014;9(4): e95492. doi:10.1371/journal.pone.0095492
Al-Asmari AK, Albalawi SM, Athar MT, Khan AQ, Al-Shahrani H, Islam M. Moringa oleifera as an anti-cancer agent against breast and colorectal cancer cell lines. PLoS One. 2015;10(8):e0135814. doi: 10.1371/journal.pone.0135814.
Jung IL, Lee JH, Kang SC. A potential oral anticancer drug candidate, Moringa oleifera leaf extract, induces the apoptosis of human hepatocellular carcinoma cells. Oncology Letters. 2015;10(3):1597–1604. doi: 10.3892/ol.2015.3482
Krishnamurthy PT, Vardarajalu A, Wadhwani A, Patel V. Identification and characterization of a potent anticancer fraction from the leaf extracts of Moringa oleifera L. Indian J Exp Biol. 2015;53(2):98-103.
Kaur H, Shantanu. Anticancer activity of a constituent from Moringa oleifera leaves. J Chem Pharm Res. 2015;7(1): 701–705.
Milugo T, Masila VM, B. Owuor et al. Anti-cancer activities of crude extracts from medicinal plants Moringa oleifera Lam and Rauwolfia caffra against selected cancer cell lines. IOSR J Pharm Biol Sci. 2016;11(3):59–64. doi:10.9790/3008-1103025964
Zayas-Viera MDM, Vivas-Mejia PE, Reyes J. Anticancer Effect of Moringa oleifera Leaf Extract in Human Cancer Cell Lines. J Health Dispa Res Prac. 2016;9(1):102. https://digitalscholarship.unlv.edu/jhdrp/vol9/iss5/102
Madi N, Dany M, Abdoun S, Usta J. Moringa oleifera's nutritious aqueous leaf extract has anticancerous effects by compromising mitochondrial viability in an ROS-Dependent Manner, J Am Coll Nutr, 2016;35(7):604–613. doi: 10.1080/07315724.2015.1080128
Guon TE, Chung HS. Moringa oleifera fruit induce apoptosis via reactive oxygen species-dependent activation of mitogen-activated protein kinases in human melanoma A2058 cells. Oncol Lett. 2017;14(2):1703‐1710. doi:10.3892/ol.2017.6288
Tragulpakseerojn J, Yamaguchi N, Pamonsinlapatham P, et al. Anti-proliferative effect of Moringa oleifera Lam (Moringaceae) leaf extract on human colon cancer HCT116 cell line. Trop J Pharm Res. 2017;16(2):371–378 doi.org/10.431/tjpr.v16i2.16
Adebayo IA, Arsad H, Samian MR. Antiproliferative effect on breast cancer (MCF7) of Moringa oleifera seed extracts. Afr J Tradit Complement Altern Med. 2017;14(2):282‐287. doi:10.21010/ajtcam.v14i2.30
Jinghua L, Linmei S, Ping H, et al. Amelioration of oxidative stress through apoptosis-mediated pathway in colon cancer cells by hexane fraction of Moringa oleifera extract. Pharma Mag. 2018;14(57):311. doi: 10.4103/pm.pm_284_17
Ndung’u JW, Anino E, Kahura Njuguna D, et al. Phytochemical Screening and Synergistic Anti-proliferative Activity against Selected Cancer Cell Lines of Moringa oleifera and Indigofera arrecta Leaf Extracts. Eur J Med Plants. 2018;23(2): 1-11. doi.org/10.9734/EJMP/2018/41021
Ali EN, Chatterton CC. Anticancer activity of Moringa oleifera leaves extract. AIP Conference Proceedings.2018;2030:020125. doi: 10.1063/1.5066766
Vipul PP, Vishal VP. Screening of Moringa oleifera Leaf Extract on Various Human Cancerious Cell Line Using Microtiter Plate Based Assay. Curr Trends Biomed Eng & Biosci. 2018;14(1):555879. doi: 10.19080/CTBEB.2018.14.555879.
Ju J, Gothai S, Hasanpourghadi M, et al. Anticancer potential of Moringa oleifera flower extract in human prostate cancer PC-3 cells via induction of apoptosis and downregulation of AKT pathway. Phcog Mag. 2018;14:477-481. doi: 10.4103/pm.pm_516_17
Potestà M, Minutolo A, Gismondi A, et al. Cytotoxic and apoptotic effects of different extracts of Moringa oleifera Lam on lymphoid and monocytoid cells. Exper Therap Med. 2019;18,1:5-17. doi.org/10.3892/etm.2019.7544
Gaffar S, Apriani R, Herlina T. n-Hexane fraction of Moringa oleifera Lam. leaves induces apoptosis and cell cycle arrest on T47D breast cancer cell Line. J Pharm Pharmacogn Res. 2019;7(3):173-183.
Tiloke C, Phulukdaree A, Gengan RM, Chuturgoon AA. Moringa oleifera aqueous leaf extract induces cell-cycle arrest and apoptosis in human liver hepatocellular carcinoma cells. Nutr Cancer. 2019;4:1-10. doi: 10.1080/01635581.2019.1597136
Do BH, Nguyen TPT, Ho NQC, Le TL, Hoang NS, Doan CC. Mitochondria-mediated Caspase-dependent and Caspase-independent apoptosis induced by aqueous extract from Moringa oleifera leaves in human melanoma cells. Mol Biol Rep. 2020;47(5):3675‐3689. doi: 10.1007/s11033-020-05462-y
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2020 European Journal of Clinical and Experimental Medicine
This work is licensed under a Creative Commons Attribution 4.0 International License.
Our open access policy is in accordance with the Budapest Open Access Initiative (BOAI) definition: this means that articles have free availability on the public Internet, permitting any users to read, download, copy, distribute, print, search, or link to the full texts of these articles, crawl them for indexing, pass them as data to software, or use them for any other lawful purpose, without financial, legal, or technical barriers other than those inseparable from having access to the Internet itself.
All articles are published with free open access under the CC-BY Creative Commons attribution license (the current version is CC-BY, version 4.0). If you submit your paper for publication by the Eur J Clin Exp Med, you agree to have the CC-BY license applied to your work. Under this Open Access license, you, as the author, agree that anyone may download and read the paper for free. In addition, the article may be reused and quoted provided that the original published version is cited. This facilitates freedom in re-use and also ensures that Eur J Clin Exp Med content can be mined without barriers for the research needs.
