Characteristics of the health-promoting properties of Cornus mas
DOI:
https://doi.org/10.15584/ejcem.2022.2.11Keywords:
bioactive compounds, cornelian cherry, Cornus mas L., medicinal plantAbstract
Introduction and aim. The medicinal properties of Cornus mas L. have been used in European and Asian folk medicine for many centuries in the prevention and treatment of many diseases. The high biological activity of the plant results primarily from the presence of valuable ingredients, including anthocyanins, flavonoids and iridoid compounds. The aim of the article is to present the role of bioactive ingredients present in C.mas that determine its health-promoting properties.
Material and methods. Review and analysis of the scientific literature.
Analysis of the literature. The summarize information about in the field of phytochemical properties and therapeutic effects, among others anticancer, antidiabetic, neuroprotective, cardioprotective and antibacterial.
Conclusion. The results of many in vitro and in vivo scientific studies They indicate the possibility of the potential use of Cornelian cherry to obtain valuable nutraceutical and pharmacological substances.
Downloads
References
Klimenko S. The cornelian cherry (Cornus mas L.): collection, preservation, and utilization of genetic resources. J Fruit Ornam Plant Res. 2004;12:93-98.
Brindza P, Brindza J, Tóth D, Klimenko O, Grigorieva O. Slovakian cornelian cherry (Cornus mas L.): Potential for cultivation. Acta Hortic (ISHS). 2007;760:433-437.
Sozański T, Kucharska AZ, Szumny A, et al.The protective effect of the Cornus mas fruits (cornelian cherry) on hypertriglyceridemia and atherosclerosis through PPARα activation in hypercholesterolemic rabbits. Phytomedicine. 2014;21:1774-1784.
Dinda B, Kyriakopoulos AM, Dinda S, et al. Cornus mas L. (cornelian cherry), an important European and Asian traditional food and medicine: Ethnomedicine, phytochemistry and pharmacology for its commercial utilization in drug industry. J Ethnopharmacol. 2016;193:670-690.
Czerwieńska ME, Melzig MF. Cornus mas and Cornus officinalis—Analogies and Differences of Two Medicinal Plants Traditionally Used. Front Pharmacol. 2018; 9:894.
Jaćimović V, BoŽović D, Ercisli S, et al. Some fruit characteristics of selected cornelian cherries (Cornus mas L.) from Montenegro. Erwerbs-Obstbau. 2015; 57:119-124.
Bilejić SM, Golšin BR, Todorović NJ, et al. Physicochemical fruit characteristics of cornelian cherry (Cornus mas L.) genotypes from Serbia. Hort Sci. 2011;46:849-853.
Kazimierski M, Regula J, Molska M. Cornelian cherry (Cornus mas L.) – characteristics, nutritional and pro-health properties. Acta Sci Pol Technol Aliment. 2019;18(1):5-12.
Milenković-Andjelković AS, Andjelković MZ, Radovanović AN, et al. Phenol composition, DPPH radical scavenging and antimicrobial activity of Cornelian cherry (Cornus mas) fruit and leaf extracts. Hem Ind. 2015;69:331-337.
Stankovic MS, Zia-Ul-Haq M, Bojovic BM, Topuzovic MD. Total phenolics, flavonoid content and antioxidant power of leaf, flower and fruits from Cornelian cherry (Cornus mas L.). Bulg J Agric Sci. 2014;20:358-336.
West BJ, Deng S, Jensen CJ, et al. Antioxidant, toxicity, and iridoids tests of processed Cornelian cherry fruits. Int J Food Sci Technol. 2021;47:1392-1397.
Kucharska AZ, Szumny A, Sokół-Łetowska A, et al. Iridoids and anthocyanins in cornelian cherry (Cornus mas L.) cultivars. J Food Comp Anal. 2015;40:95-102.
Biaggi DM, Donno D, Mellano MG, et al. Cornus mas (L.) Fruit as a Potential Source of Natural Health-Promoting Compounds: Physico-Chemical Characterisation of Bioactive Components. Plant Foods Hum Nutr. 2018;73:89-94.
Boris P, Stajner DI, Keversan S, et al. Antioxidant capacity of cornelian cherry (Cornus mas L.) - Comparison between permanganate reducing antioxidant capacity and other antioxidant methods. Food Chem. 2012;134(2):734-741.
Piórecki N. Dereń jadalny (Cornus mas L.) – właściwości i możliwości. Szkółkarstwo, 2007;3:86-88.
Guleryuz M, Bolat I, Pirlak L. Selection of table cornelian cherry (Cornus mas L.) types in Coruh Valley. Turk J Agric Forestry. 1998;22:357-364.
Pantelidis GE, Vasilakakis M, Manganaris GA, et al. Antioxidant capacity, phenol, anthocyanin and ascorbic acid contents in raspberries, red currants, gooseberries and cornelian cherries. Food Chem. 2007;102:777-783.
Horváth G, Turcsi E, Molnár P, et al. Isolation and identification of carotenoids in the fruit of cornelian cherry (Cornus mas L.). Planta Med. 2007;73:286.
Benzie IFF. Evolution of dietary antioxidants. Comp Biochem Physiol Part A Mol Integr Physiol. 2003;136(1):113-126.
Pisoschi AM, Pop A, Iordache F, Stanca L, Predoi G, Serban AI. Oxidative stress mitigation by antioxidants - An overview on their chemistry and influences on health status. Eur J Med Chem. 2021;209:112891.
Leja M, Mareczek A, Nanaszko B. Antyoksydacyjne właściwości owoców wybranych gatunków dziko rosnących drzew i krzewów. Rocz AR Pozn Ogrodn. 2007;41:327-331.
Celep E, Aydin A, Yesilada EA. Comparative study on the in vitro antioxidant potentials of three edible fruits: cornelian cherry, Japanese persimmon and cherry laurel. Food Chem Toxicol. 2012;50:3329-3335.
Popović BM, Štajner D, Slavko K, et al. Antioxidant capacity of cornelian cherry (Cornus mas L.)–comparison between permanganate reducing antioxidant capacity and other antioxidant methods. Food Chem. 2012;134:734-741.
Pyrkosz-Biardzka K, Kucharska A, Sokol-Łetowska A, et al. A comprehensive study on antioxidant properties of crude extracts from fruits of Berberis vulgaris L., Cornus mas L. and Mahonia aquifolium. Nutt Pol J Food Nutr Sci 2014;64:91-99.
Hosu A, Cimpoiu C, David L, et al. Study of the antioxidant property variation of cornelian cherry fruits during storage using HPTLC and spectrophotometric assays. J Anal Methods Chem. 2016;2016:2345375.
Moldovan B, Filip A, Clichici S, et al. Antioxidant activity of Cornelian cherry (Cornus mas L.) fruits extract and the in vivo evaluation of its anti-inflammatory effects. J Funct Foods. 2016;26:77-87.
Desai SJ, Prickril B, Rasooly A. Mechanisms of Phytonutrient Modulation of Cyclooxygenase-2 (COX-2) and Inflammation Related to Cancer. Nutr Cancer. 2018;70(3):350-375.
Choi YH, Jin GY, Li GZ, et al. Cornuside suppresses lipopolysaccharide-induced inflammatory mediators by inhibiting nuclear factor-kappa B activation in RAW 264.7 macrophages. Biol Pharm Bull. 2011;34(7):959-966.
Peyman MK, Maziar SB, Shahin A, et al. Therapeutic uses and pharmacological effects of Cornus mas A review. J Pharm Biomed Sci. 2014;6:1732-1738.
Guy M, John A H. Apoptosis and cancer chemotherapy. Cell Tissue Resh. 2000;301:143-152.
Ghobrial IM, Witzig TE, Adjei AA. Targeting apoptosis pathways in cancer therapy. Cancer J Clin. 2005;55:178-194.
Sak K. Cytotoxicity of dietary flavonoids on different human cancer types. Pharmacogn Rev. 2014;8(16):122-146.
Savikin K, Zdunic G, Jankovic T, et al. In vitro cytotoxic and antioxidative activity of Cornus mas and Cotinus coggygria. Nat Prod Res. 2009;18:1731-1739.
Yousefi B, Abasi M, Abbasi MM, Jahanban-Esfahlan R, Anti-proliferative properties of Cornus mass fruit in different human cancer cells. Asian Pacific J Cancer Prev. 2015;16(14):5727-5731.
Forman V, Haladová M, Grančai D, Ficková M, Antiproliferative activities of water infusions from leaves of five Cornus L. species. Molecules., 2015;20(12):22546-22552.
Tiptiri-Kourpeti A, Fitsiou E, Spyridopoulou K, Vasileiadis S, Iliopoulos C, Galanis A, Chlichlia K. Evaluation of antioxidant and antiproliferative properties of Cornus mas L. fruit juice. Antioxidants, 2019;8(9):377.
Park CH, Noh JS, Tanaka T, et al. The effects of corni fructus extract and its fractions against alpha-glucosidase inhibitory activities in vitro and sucrose tolerance in normal rats. Am J Chin Med. 2011;39:367-380.
Asgary S, Rafieian-Kopaei M, Shamsi F, et al. Biochemical and histopathological study of the anti-hyperglycemic and anti-hyperlipidemic effects of cornelian cherry (Cornus mas L.) in alloxan-induced diabetic rats. J Complement Integr Med. 2014;11:63-69.
Shishehbor F, Azemi ME, Zameni D, et al. Inhibitory effects of hydroalcoholic extracts of barberry, sour cherry and Cornelian cherry on α-amylase and α-glucosidase activities. Int J Pharm Res Allied Sci. 2016;5:423-428.
Soltani R, Gorji A, Asgary S, et al. Evaluation of the Effects of Cornus mas L. Fruit Extract on Glycemic Control and Insulin Level in Type 2 Diabetic Adult Patients: A Randomized Double-Blind Placebo-Controlled Clinical Trial. Evid Based Complement Alternat Med. 2015;2015:740954.
Zhang W, Hong D, Zhou Y, et al. Ursolic acid and its derivative inhibit protein tyrosine phosphatase 1B, enhancing insulin receptor phosphorylation and stimulating glucose uptake. Biochim Biophys Acta. 2006;1760(10):1505-1512.
Sozański T, Kucharska AZ, Rapak A, et al. Iridoid-loganic acid versus anthocyanins from the Cornus mas fruits (cornelian cherry): Common and different effects on diet-induced atherosclerosis, PPARs expression and inflammation. Atherosclerosis. 2016;254:151-160.
Asgary S, Rafieian-Kopaei M, Shamsi F, et al. The effects of cornelian cherry on atherosclerosis and atherogenic factors in hypercholesterolemic rabbits. J Med Plants Res. 2011;5(13):2670-2676.
A Tsuda T, Horio F, Uchida K, et al. Dietary cyanidin 3-O-beta-D-glucoside-rich purple corn color prevents obesity and ameliorates hyperglycemia in mice. J Nutr. 2003;133(7):2125-2130.
Lefevre M, Wiles JE, Zhang X, et al. Expression microarray analysis of the effects of grape anthocyanins in mice: a test of a hypothesis-generating paradigm. Metabolism. 2008;57(7):52-57.
Hosseinpour F, Shomali T, Rafieian-Kopaei M. Hypocholesterolemic activity of cornelian cherry (Cornus mas L.) fruits. J Complement Integr Med. 2017;14(4). doi:10.1515/jcim-2017-0007
Gholipour S, Shomali T, Rafieian-Kopaei M. Anti-hypertriglyceridemic activity of Cornus mas in diabetic rats. J Clin Diag Res. 2018;12(8):1-5.
Świerczewska A, Buchholz T, Melzig MF, Czerwińska ME, In vitro α-amylase and pancreatic lipase inhibitory activity of Cornus mas L. and Cornus alba L. fruit extracts. J Food and Drug Anals. 2019;27(1):249-258.
Fraser R, Ingram MC, Anderson NH, et al. Cortisol effects on body mass, blood pressure, and cholesterol in the general population. Hypertension. 1999; 33(6):1364-1368.
Lofti A, Shahryar A, Rasoolian H. Effects of cornelian cherry (Cornus mas L.) fruit on plasma lipids, cortisol, T3 and T4 levels in hamsters. J Anim Plant Sci. 2014;24:459-462.
Asgary S, Kelishadi R, Rafieian-Kopaei M, et al. Investigation of the lipid-modifying and antiinflammatory effects of Cornus mas L. supplementation on dyslipidemic children and adolescents. Pediatr Cardiol. 2013;34(7):1729-1735.
Asgary S, Rafieian-Kopaei M, Adelnia A, et al. Comparing the effects of lovastatin and Cornus mas fruit on fibrinogen level in hypercholesterolemic rabbits. ARYA Atheroscler. 2010;6(1):1-5.
Rafieian-Kopaei M, Asgary S, Adelnia A, et al. The effects of cornelian cherry on atherosclerosis and atherogenic factors in hypercholesterolemic rabbits. J Med Plants Res. 2011;5:2670-2676.
Gholamrezayi A, Aryaeian N, Rimaz S, Abolghasemi J, Fallah S, Moradi N, Taghizadeh M. The effect of Cornus mas fruit extract consumption on lipid profile, glycemic indices, and leptin in postmenopausal women- a randomized clinical trial. Phytotherapy Res. 2019;33(11):2979-2988.
Alavian SM, Banihabib N, Es Haghi M, et al. Protective Effect of Cornus mas Fruits Extract on Serum Biomarkers in CCl4-Induced Hepatotoxicity in Male Rats. Hepat Mon. 2014;14(4):10330.
Abbasi M, Abdollahi B, Milani P, et al. Effects of hydro-methanolic extract of Cornus mas on histopathological and biochemical parameters of rats' liver and kidney. Bothalia J. 2014;44:250-259.
Saei H, Hatami H, Azarmi M, et al. Hepatoprotective effect of Cornus mas fruits extract on serum biomarkers in methotrexate induced liver injury in male rats. Pharmacol. 2016;1:91-98.
Abbasi MM, Hassanalilou T, Khordadmehr M, et al. Effects of Cornus mas Fruit Hydro-Methanolic Extract on Liver Antioxidants and Histopathologic Changes Induced by Cisplatin in Rats. Indian J Clin Biochem. 2020;35(2):218-224.
Cooper EL, Ma MJ. Alzheimer disease: clues from traditional and complementary medicine. J. Tradit. Complement. Med. 2017;7:380-385.
Francik R, Kryczyk J, Krośniak M, et al. The neuroprotective effect of Cornus mas on brain tissue of Wistar rats. Scientific World Journal. 2014;847368.
Francik R, Kryczyk-Kozioł J, Krośniak M, Francik S. Activity of para oxonase 1 and lipid profile in rats fed cornelian cherry or chokeberry in different types of diet. Act Pol Pharma - Drug Research, 2017;74(6):1683-1679.
Turker A, Yildirim A, Karakas F. Antibacterial and antitumor activities of some wild fruits grown in Turkey. Biotechnol Biotechnol Eq. 2012;26:2765-2772.
Radovanović BC, Milenković-Andelković AS, Radovanović AB, et al. Antioxidant and antimicrobial activity of polyphenol extracts from wild berry fruits grown in Southeast Serbia. Trop J Pharmaceut Res. 2013;12:813-819.
Kyriakopoulos AM, Dinda B. Cornus mas (Linnaeus) novel devised medicinal preparations: bactericidal effect against Staphylococcus aureus and Pseudomonas aeruginosa. Molecules 2015;20:11202-11218.
Hosseinpour-Jaghdani F, Shomali T, Gholipour-Shahraki A, et al. Cornus mas: a review on traditional uses and pharmacological properties. J Complement Integr Med 2017;14:20160137.
Krisch J, Galgóczy L, Tölgyesì M, Papp T, Vágvölgyi C. Effect of fruit juices and pomace extracts on the growth of gram-positive and gram-negative bacteria. Acta Biol Szeg. 2008;52(2):267-270.
Krzyściak P, Krosniak M, Gąstoł M, et al. Antimicrobial activity of Cornelian cherry (Cornus mas L.). Postępy Fitoterapii, 2011;4:227-231.
Antolak H, Czyzowska A, Sakač M, et al. Phenolic Compounds Contained in Little-known Wild Fruits as Antiadhesive Agents Against the Beverage-Spoiling Bacteria Asaia spp. Molecules. 2017;22(8):1256.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2022 European Journal of Clinical and Experimental Medicine
This work is licensed under a Creative Commons Attribution 4.0 International License.
Our open access policy is in accordance with the Budapest Open Access Initiative (BOAI) definition: this means that articles have free availability on the public Internet, permitting any users to read, download, copy, distribute, print, search, or link to the full texts of these articles, crawl them for indexing, pass them as data to software, or use them for any other lawful purpose, without financial, legal, or technical barriers other than those inseparable from having access to the Internet itself.
All articles are published with free open access under the CC-BY Creative Commons attribution license (the current version is CC-BY, version 4.0). If you submit your paper for publication by the Eur J Clin Exp Med, you agree to have the CC-BY license applied to your work. Under this Open Access license, you, as the author, agree that anyone may download and read the paper for free. In addition, the article may be reused and quoted provided that the original published version is cited. This facilitates freedom in re-use and also ensures that Eur J Clin Exp Med content can be mined without barriers for the research needs.
