Natural properties of lycopene and its application in medicine
DOI:
https://doi.org/10.15584/ejcem.2021.2.8Keywords:
carotenoid, lycopene, medicineAbstract
Introduction. The subject of the article is a chemical compound belonging to the carotenoid family, i.e. lycopene.
Aim. The aim of this study was to describe interest among scientists regarding lycopene due to its unique properties, general availability and potential for wide application in medicine.
Material and methods. This article is a review in which the properties of lycopene, its chemical structure and sources (especially in the form of tomato fruits and its products), as well as its important role and importance in medicine, is presented.
Analysis of the literature. Lycopene is an interesting compound with interesting properties. It may prove to be an important and readily available means of preventing and fighting cancer (especially prostate cancer, uterine cancer and breast cancer). Additionally, lycopene can counteract cardiovascular diseases that are common nowadays.
Conclusion. The data indicates increased number of papers regarding applications of lycopene in medicine.
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References
Qu Y, Su A, Li Y, Meng Y, Chen Z. Manipulation of the Regulatory Genes Rhodobacter sphaeroides Enhances Lycopene Production. J Agric Food Chem. 2021;69(14):4134-4143.
McTiernan A. Dietary prevention of breast cancer in high-risk women: role of carotenoids. Am J Clin Nutr. 2021;113(3):499-500.
Xie Z, Yang F. The effects of lycopene supplementation on serum insulin-like growth factor 1 (IGF-1) levels and cardiovascular disease: A dose-response meta-analysis of clinical trials. Complement Ther Med. 202156:102632.
Gopinath H, Karthikeyan K, Meghana V. For the love of color: Plant colors and the dermatologist. Indian J Dermatol Venereol Leprol. 202086(6):622-629.
Dumont D, Danielato G, Chastellier A, et al. Multi-Targeted Metabolic Profiling of Carotenoids, Phenolic Compounds and Primary Metabolites in Goji Lycium.) Berry and Tomato Solanum lycopersicum Reveals Inter and Intra Genus Biomarkers. Metabolites. 2020;10(10):422.
Wise LA, Wesselink AK, Bethea TN, et al. Intake of Lycopene and other Carotenoids and Incidence of Uterine Leiomyomata: A Prospective Ultrasound Study. J Acad Nutr Diet. 2021 121(1):92-104.
Vats S, Bansal R, Rana N, et al. Unexplored nutritive potential of tomato to combat global malnutrition. Crit Rev Food Sci Nutr. 2020:1-32.
Zhu K, Zheng X, Ye J, et al. Building the Synthetic Biology Toolbox with Enzyme Variants to Expand Opportunities for Biofortification of Provitamin A and Other Health-Promoting Carotenoids. J Agric Food Chem. 2020;68(43):12048-12057.
Li N, Wu X, Zhuang W, et al. Tomato and lycopene and multiple health outcomes: Umbrella review. Food Chem. 2021;343:128396.
Sakemi Y, Sato K, Hara K, Honda M, Shindo K. Biological Activities of Z-Lycopenes Contained in Food. J Oleo Sci. 2020;69(11):1509-1516.
Wang J, Huang C, Guo K, et al. Converting Escherichia coli MG1655 into a chemical overproducer through inactivating defense system against exogenous DNA. Synth Syst Biotechnol. 2020;5(4):333-342.
Kumari GUWUP, Gunathilake KDPP. In vitro bioaccessibility and antioxidant activity of black plum (Syzygium caryophyllatum). J Food Biochem. 2020;44(12):e13499.
Zhao Y, Ma DX, Wang HG, et al. Lycopene Prevents DEHP-Induced Liver Lipid Metabolism Disorder by Inhibiting the HIF-1α-Induced PPARα/PPARγ/FXR/LXR System. J Agric Food Chem. 2020;68(41):11468-11479.
Loayza FE, Brecht JK, Simonne AH, et al. A brief hot-water treatment alleviates chilling injury symptoms in fresh tomatoes. J Sci Food Agric. 2021;101(1):54-64.
Ali A, Saliem S, Abdulkareem A, Radhi H, Gul S. Evaluation of the efficacy of lycopene gel compared with minocycline hydrochloride microspheres as an adjunct to nonsurgical periodontal treatment: A randomised clinical trial. J Dent Sci. 2021;16(2):691-699.
van Steenwijk HP, Bast A, de Boer A. The Role of Circulating Lycopene in Low-Grade Chronic Inflammation: A Systematic Review of the Literature. Molecules. 2020;25(19):4378.
Gupta N, Kalaskar A, Kalaskar R. Efficacy of lycopene in management of Oral Submucous Fibrosis- A systematic review and meta-analysis. J Oral Biol Craniofac Res. 2020;10(4):690-697.
Grabowska M, Wawrzyniak D, Rolle K, Chomczyński P, Oziewicz S, Jurga S, Barciszewski J. Let food be your medicine: nutraceutical properties of lycopene. Food Funct. 2019;10(6):3090-3102.
Bacanli M, Başaran N, Başaran AA. Lycopene: Is it Beneficial to Human Health as an Antioxidant? Turk J Pharm Sci. 2017;14(3):311-318.
Kelkel M, Schumacher M, Dicato M, Diederich M. Antioxidant and anti-proliferative properties of lycopene. Free Radic Res. 2011;45(8):925-40.
Zhai LL, Tang ZG. Lycopene improves sperm motility and morphology: a promising agent for treating male infertility. Eur J Nutr. 2020;59(2):835-836.
Williams EA, Pacey A. Reply to the letter: Lycopene improves sperm motility and morphology: a promising agent for treating male infertility. Eur J Nutr. 2020;59(2):837.
Saini RK, Rengasamy KRR, Mahomoodally FM, Keum YS. Protective effects of lycopene in cancer, cardiovascular, and neurodegenerative diseases: An update on epidemiological and mechanistic perspectives. Pharmacol Res. 2020 May;155:104730.
Pogoda K, Pucka M, Tabarkiewicz J, et al. Lycopene activity on lung and kidney cancer cells by T2 relaxation time 1H Magnetic Resonance Imaging in vitro. Eur J Clin Exp Med. 2020;18 (1):5–9.
Steiner AZ, Hansen KR, Barnhart KT, et al. Reproductive Medicine Network. The effect of antioxidants on male factor infertility: the Males, Antioxidants, and Infertility (MOXI) randomized clinical trial. Fertil Steril. 2020;113(3):552-560.e3.
Cheng HM, Koutsidis G, Lodge JK, Ashor A, Siervo M, Lara J. Tomato and lycopene supplementation and cardiovascular risk factors: A systematic review and meta-analysis. Atherosclerosis. 2017;257:100-108.
Palozza P, Catalano A, Simone RE, Mele MC, Cittadini A. Effect of lycopene and tomato products on cholesterol metabolism. Ann Nutr Metab. 2012;61(2):126-34.
Cuevas-Ramos D, Almeda-Valdés P, Chávez-Manzanera E, et al. Effect of tomato consumption on high-density lipoprotein cholesterol level: a randomized, single-blinded, controlled clinical trial. Diabetes Metab Syndr Obes. 2013;6:263-73.
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