Expression of CD 43 and PSGL-1 on peripheral blood neutrophils of patients with Lyme borreliosis
Keywords:
Lyme boreliosis, neutrophils, adhesion molecules, CD43, PSGL-1Abstract
The aim of the study was to evaluate mRNA of CD43 of patients with Lyme borreliosis. Investigations conducted at patients with Lyme boreliosis did not show the essential differences in expression both the mRNA the PSGL-1 how and mRNA CD 43 in neutrophils. However we affirmed the essential growth the soluble PSGL-1 in serum of the patients with Lyme boreliosis. The growth observed in own investigations of concentration of soluble forms the PSGL across it blocking on neutrophils specific ligand it can lead to set – back of inflammatory.
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Ardman B., Sikorski M., Staunton D: CD43 Interferes with T-Lymphocyte Adhesion Proc.Natl. Acad.Sci.USA 1995, 89,5001–6
Atkin E., Aversa J., Steere A. C. Expression of adhesion molecules in synovia of patients with treatment resistant lyme arthritis. Infect. Immun. 2001; 69, 1774–80
Banawarth A.: Chronische lymphocytarie meningitis endzündlichepolyneuritis und reumatismius. Arch Psychiatr Nervenkr. 1941;113:284–376
Behera A.K, Hildebrand E, Uemastu M: Identification of a TLR-independent pathway for Borrelia burgdorferiinduced expression of matrix metalloproteinases and inflammatory mediators through binding to integrin alpha 3 beta 1. J. Immunol 2006, 177, 657–664.
Boggenmeyer E., Stehle T., Schaible U.E., Hahne M., Vestweber D., Simon M.M.: Borrelia burgdorferi upregulates the adhesion molecules E- selectin, P-selectin, ICAM–1 and VCAM–1 on mouse endothelioma cells in vitro. Cells Adhes. Commun. 1994, 2, 145–157.
Coburn J., Leong J.M., Erban J.K.: Integrin λ5β3 mediated binding of the Lyme disease agent Borrelia burgdorferi to human platelets. Proc Natl Acad Sci USA 1993, 90,7059–63
Etzioni M.: Leukocyte adhesion deficiency II: a group of integrin activation defects in hematopoietic lineage cells. Curr Opin Allergy Clin Immunol. 2004 Dec,4, 485–90
Gebbia J.A., Coleman J.L., Benach J.L.: Borrelia spirochetes upregulate release and activation of matrix metalloproteinase gelatinase B (MMP–9) and collagenase 1 (MMP–1) in human cells. Infect Immun. 2001, 69:456–62
Górski A.: The role of cell adhesion molecules in immunopathology. Immunol. Today 1994,15,251.
Iżycka A., Jabłońska E., Zajkowska J.: Expression of LFA –1 and L- selectin on peripheral blood neutrophils and concentrations of soluble forms of sICAM –1 and sL – selectin in blood serum of patients with Lyme borreliosis. Praca wysłana do druku Acta Mcrobiologica
Iżycka A., Jabłońska E., Zajkowska J., i in.: Bakteriobójcze właściwości granulocytów obojętnochłonnych (PMN) krwi obwodowej u chorych z boreliozą z Lyme. Med Dośw Mikrobiol 2000; 52:165
Ley E.: Molecular mechanisms of leukocyte rolling and adhesion to microvascular endothelium. Eur. Heart J. 1993,14 supl. lI 68–73.
Lusitani D., Malawista S.E., Montgomery R.R.: Borrelia burgdorferi are susceptible to killing by a variety of PMN components. J. Infect. Dis. 2002;185:797–804.
Ma Y., Seiler K.P., Tai K.F., Yang L., Woods M.: Outer surface lipoproteins of Borrelia burgdorferi stimulate nitric oxide production by the cytokine-inducible pathway. Infect. Immun., Sep 1994; 62: 3663–3671.
Martinez M., Joffraud M., Giraud S.: Regulation of PSGL-1 interactions with L-selectin, P-selectin, and E-selectin: Role of human fucosyltransferase-IV and -VII. J. Biol. Chem 2005, 280,5378–5390
McEver M.: P-selectin and PSGL–1: exploiting connections between inflammation and venous thrombosis. Thromb Haemost. 2002;87(3):364–5.
McFartland A., Ardman B., Manjunath R.: CD43diminishes susceptibility to T lymphocyte mediated cytolysis. J. Immunol 1995, 154, 1097–1104.
Schumacher M., Siebers A.: P-selectin glycoprotein ligand–1 (PSGL–1) is up-regulated on leucocytes from patients with chronic obstructive pulmonary disease. Clin Exp Immunol. 2005;142,370–6.
Sellati T.J., Burms M.J., Ficazolla M.: Borrelia burgdorferi upregulates expression of adhesion molecules on endothelial cells and promoters transendothelial migration of neutrophils in vitro. Infect. Immun. 1995, 4439–4447.
Welpy J.K., Keene J.L., Schmuke J.J. i wsp.: Selectin as potential targets of therapeutic intervention in inflammatory diseases. Biochim. Bophys. Acta 1994,1197,215.
Woodman R., Brent J., Hickey M.: The Functional Paradox of CD43 in Leukocyte Recruitment:A Study Using CD43-deficient Mice. J. Exp. Med. 1998, 188, 2181
Zanardo R., Bonder J.: A down-regulatable E-selectin ligand is functionally important for PSGL–1–independent leukocyte–endothelial cell interactions. Blood, 2004; 104: 3766–773.
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