Prevalence of celiac disease in children and adolescents with diabetes mellitus type 1 in Podkarpatian Region
Keywords:
diabetes mellitus, celiac disease, screening test, childrenAbstract
The prevalence of celiac disease among children with type I diabetes mellitus exceeds the prevalence of the condition in the general population. To investigate the prevalence of celiac disease in the large cohort of children and adolescents with type 1 diabetes mellitus was the aim of the study.
Material and methods: 765 children from the Podkarpatian Region with diabetes type 1 diagnosed in years 1990-2005 were enrolled into the study. Prospective serologic screening was performed in 355 children with diabetes diagnosed during 5 consecutive years between January 2000 and December 2005. Among 410 children with diabetes diagnosed in the period of 10 years - between January 1990 and December 1999, serologic tests for celiac disease were performed exclusively in children with clinical symptoms of malabsorption syndrome. Intestinal biopsy was performed in all children with positive results of serologic tests. 60
Results. Celiac disease was diagnosed in 8 out of 355 children (2,25%) screened in the years 2000– 2005 and in 3 out of 410 children with diabetes mellitus type 1 diagnosed in the years 1990-1999.
Conclusions. The prevalence of celiac disease in children and adolescents with diabetes type 1 in podkarpatian region is relatively low. Screening for celiac disease in type 1 diabetes, although costly, was an effective method to detect silent form of the disease.
Downloads
References
Maki M., Hallstrom O., Huupponen T., Vesikari T., Visakorpi J.K., Increased prevalence of coeliac disease in diabetes, Arch Dis Child. 1984; 59(8): 739.
Sigurs N., Johansson C., Elfstrand P.O., Viander M., Lanner A., Prevalence of coeliac disease in diabetic children and adolescents in Sweden, Acta Paediatr. 1993; 82(9): 748.
De Vitis I., Ghirlanda G., Gasbarrini G., Prevalence of coeliac disease in type I diabetes: a multicentre study, Acta Paediatr Suppl. 1996; 412: 56.
Cronin C.C., Feighery A., Ferriss J.B., Liddy C., Shanahan F., Feighery C., High prevalence of celiac disease among patients with insulin-dependent (type I) diabetes mellitus, Am J Gastroenterol. 1997; 92(12): 2210–2.
Hansen D., Bennedbaek F.N., Hansen L.K., Hoier-Madsen M., Hegedu L.S., Jacobsen B.B. i wsp.: High prevalence of coeliac disease in Danish children with type I diabetes mellitus, Acta Paediatr. 2001; 90(11): 1238–43.
Tanure M.G., Silva I.N., Bahia M., Penna F.J.: Prevalence of Celiac Disease in Brazilian Children with Type 1 Diabetes Mellitus. J Pediatr Gastroenterol Nutr. 2006; 42(2): 155.
Cronin C.C., Shanahan F.: Insulin-dependent diabetes mellitus and coeliac disease,s Lancet. 1997; 349(9058): 1096.
Pena A.S., Garrote J.A., Crusius J.B., Advances in the immunogenetics of coeliac disease. Clues for understanding the pathogenesis and disease heterogeneity, Scand J Gastroenterol Suppl. 1998; 225: 56.
Collin P., Kaukinen K., Valimaki M., Salmi J., Endocrinological disorders and celiac disease, Endocr Rev. 2002;23(4): 464–83.
Holmes G.K., Coeliac disease and Type 1 diabetes mellitus – the case for screening Diabet Med. 2001; 18(3): 169.
Barera G., Bonfanti R., Viscardi M., Bazzigaluppi E., Calori G., Meschi F. i wsp.: Occurrence of celiac disease after onset of type 1 diabetes: a 6-year prospective longitudinal study, Pediatrics. 2002;109(5): 833.
Freemark M., Levitsky L.L.: Screening for celiac disease in children with type 1 diabetes: two views of the controversy, Diabetes Care. 2003;26(6): 1932.
Holmes G.K., Screening for coeliac disease in type 1 diabetes, Arch Dis Child. 2002;87(6): 495.
Schober E., Rami B., Granditsch G., Crone J., Coeliac disease in children and adolescents with type 1 diabetes mellitus: to screen or not, to treat or not? Horm Res. 2002;57 Suppl 1: 97.
Amin R., Murphy N., Edge J., Ahmed M.L., Acerini C.L., Dunger D.B., A longitudinal study of the effects of a gluten-free diet on glycemic control and weight gain in subjects with type 1 diabetes and celiac disease, Diabetes Care. 2002;25(7): 1117.
Collin P., Pirttila T., Nurmikko T., Somer H., Erila T., Keyrilainen O., Celiac disease, brain atrophy, and dementia, Neurology. 1991; 41(3): 372.
Hernandez M.A., Colina G., Ortigosa L., Epilepsy, cerebral calcifications and clinical or subclinical coeliac disease. Course and follow up with gluten-free diet, Seizure. 1998;7(1): 49.
Kieslich M., Errazuriz G., Posselt H.G., Moeller-Hartmann W., Zanella F., Boehles H., Brain white-matter lesions in celiac disease: a prospective study of 75 diettreated patients, Pediatrics. 2001; 108(2): E21.
Mohn A., Cerruto M., Lafusco D., Prisco F., Tumini S., Stoppoloni O. i wsp.: Celiac disease in children and adolescents with type I diabetes: importance of hypoglycemia, J Pediatr Gastroenterol Nutr. 2001; 32(1): 37–40.
Not T., Tommasini A., Tonini G., Buratti E., Pocecco M., Tortul C. i wsp.: Undiagnosed coeliac disease and risk of autoimmune disorders in subjects with Type I diabetes mellitus, Diabetologia. 2001; 44(2): 151.
Mora S., Barera G., Ricotti A., Weber G., Bianchi C., Chiumello G., Reversal of low bone density with a gluten-free diet in children and adolescents with celiac disease, Am J Clin Nutr. 1998; 67(3): 477.
Catassi C., Fabiani E., Corrao G., Barbato M., De Renzo A., Carella AM. i wsp. Italian Working Group on Coeliac Disease and Non-Hodgkin's-Lymphoma: Risk of non-Hodgkin lymphoma in celiac disease, JAMA. 2002; 287(11): 1413.
Collin P., Vilska S., Heinonen P.K., Hallstrom O., Pikkarainen P., Infertility and coeliac disease, Gut. 1996; 39(3): 382.
Meloni G.F., Dessole S., Vargiu N., Tomasi P.A., Musumeci S., The prevalence of coeliac disease in infertility, Hum Reprod. 1999; 14(11): 2759.
Bruno G., Merletti F., Biggeri A., Cerutti F., Grosso N., De Salvia A. i wsp., Piedmont Study Group for Diabetes Epidemiology. Increasing trend of type I diabetes in children and young adults in the province of Turin (Italy). Analysis of age, period and birth cohort effects from 1984 to 1996, Diabetologia. 2001; 44(1): 22.
Mauny F., Grandmottet M., Lestradet C., Guitard J., Crenn D., Floret N. i wsp., Increasing trend of childhood type 1 diabetes in Franche-Comte (France): analysis of age and period effects from 1980 to 1998, Eur J Epidemiol. 2005; 20(4): 325.
Diabetes Epidemiology Research International Group: Secular trends in incidence of childhood IDDM in 10 countries, Diabetes. 1990; 39(7): 858.
Gardner S.G., Bingley P.J., Sawtell P.A., Weeks S., Gale E.A., Rising incidence of insulin dependent diabetes in children aged under 5 years in the Oxford region: time trend analysis. The Bart's-Oxford Study Group. BMJ. 1997; 315(7110): 713.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2006 Medical Journal of the Rzeszow University
This work is licensed under a Creative Commons Attribution 4.0 International License.
Our open access policy is in accordance with the Budapest Open Access Initiative (BOAI) definition: this means that articles have free availability on the public Internet, permitting any users to read, download, copy, distribute, print, search, or link to the full texts of these articles, crawl them for indexing, pass them as data to software, or use them for any other lawful purpose, without financial, legal, or technical barriers other than those inseparable from having access to the Internet itself.
All articles are published with free open access under the CC-BY Creative Commons attribution license (the current version is CC-BY, version 4.0). If you submit your paper for publication by the Eur J Clin Exp Med, you agree to have the CC-BY license applied to your work. Under this Open Access license, you, as the author, agree that anyone may download and read the paper for free. In addition, the article may be reused and quoted provided that the original published version is cited. This facilitates freedom in re-use and also ensures that Eur J Clin Exp Med content can be mined without barriers for the research needs.
