Autoimmune polyglandular syndromes

Authors

  • Aleksandra Januszek-Trzciąkowska Z Katedry i Kliniki Pediatrii, Endokrynologii i Diabetologii Dziecięcej Śląskiej Akademii Medycznej w Katowicach
  • Ewa Małecka-Tendera Z Katedry i Kliniki Pediatrii, Endokrynologii i Diabetologii Dziecięcej Śląskiej Akademii Medycznej w Katowicach
  • Barbara Kalina-Faska Z Katedry i Kliniki Pediatrii, Endokrynologii i Diabetologii Dziecięcej Śląskiej Akademii Medycznej w Katowicach
  • Maria Kalina Z Katedry i Kliniki Pediatrii, Endokrynologii i Diabetologii Dziecięcej Śląskiej Akademii Medycznej w Katowicach

Keywords:

infections, microorganisms, resistance mechanisms

Abstract

Autoimmune polyglandular syndromes – APS are rare disorders of complex clinical manifestation. APS I is characterized by candidiasis of the skin and mucous membranes, hypoparathyroidism and adrenal insufficiency. APS II comprises adrenal insufficiency, autoimmune thyroid disease and diabetes mellitus type 1. APS III consists of autoimmune thyroid disease in connection with endocrinopathy other than adrenal insufficiency (eg. premature gonad failure, diabetes mellitus type 1). Mutations of AIRE gene are responsible for the development of APS I, and inheritance is autosomal recessive, monogenic. Syndromes APS II and III exhibit polygenic inheritance and are connected with the HLA system. The presented report reviews pathogenesis, clinical symptoms and complex treatment as well as follow-up of patients with autoimmune polyglandular syndromes.

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References

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Published

2007-09-30

How to Cite

Januszek-Trzciąkowska, A., Małecka-Tendera, E., Kalina-Faska, B., & Kalina, M. (2007). Autoimmune polyglandular syndromes. European Journal of Clinical and Experimental Medicine, 5(3), 264–267. Retrieved from https://journals.ur.edu.pl/ejcem/article/view/13330

Issue

Vol. 5 No. 3 (2007): Medical Journal of the Rzeszow University

Section

REVIEW PAPERS

License

Copyright (c) 2007 Medical Journal of the Rzeszow University

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