"Valeriana officinalis" – a review
DOI:
https://doi.org/10.15584/ejcem.2022.3.2Keywords:
insomnia, valerian, valeriana, valeriana officinalisAbstract
Introduction and aim. Valeriana officinalis has been recognized in traditional medicine and used since ancient times for a variety of health ailments. It is mainly appreciated for its sedative and sleeping properties. Currently, scientists are conducting numerous studies on the exact chemical composition of valerian and the properties they carry in the human body.
Material and methods. This paper presents a narrative review on valerian.
Analysis of the literature. The desire to summarize information on the uses and properties of V. officinalis is presented. V. officinalis exhibits sedative, sleep-inducing and antidepressant properties. Studies show broad effects on the human nervous system, for example, reducing stress.
Conclusion. By discovering new properties of valerian, its properties are expanding significantly day by day. Its main use is primarily in the treatment of sleep disorders and nervous system disorders. However, it is also used in headaches, depression, anti-cancer therapy, urinary and digestive disorders. More and more people are turning to valerian as an alternative to drugs that have more side effects.
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References
LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012.
Shinjyo N, Waddell G, Green J. Valerian Root in Treating Sleep Problems and Associated Disorders-A Systematic Review and Meta-Analysis. J Evid Based Integr Med. 2020;25:2515690X20967323.
Halson SL. Sleep in elite athletes and nutritional interventions to enhance sleep. Sports Med. 2014;44(Suppl 1):S13‒S23.
Bhaskar S, Hemavathy D, Prasad S. Prevalence of chronic insomnia in adult patients and its correlation with medical comorbidities. J Family Med Prim Care. 2016;5(4):780‒784.
Bruni O, Ferini-Strambi L, Giacomoni E, Pellegrino P. Herbal Remedies and Their Possible Effect on the GABAergic System and Sleep. Nutrients. 2021;13(2):530.
Azizi H, Shojaii A, Hashem-Dabaghian F, et al. Effects of Valeriana officinalis (Valerian) on tension-type headache: A randomized, placebo-controlled, double-blind clinical trial. Avicenna J Phytomed. 2020;10(3):297‒304.
Dietz BM, Hajirahimkhan A, Dunlap TL, Bolton JL. Botanicals and Their Bioactive Phytochemicals for Women's Health. Pharmacol Rev. 2016;68(4):1026‒1073.
Kara M, Alparslan ED, Öztaş E, Erdoğan ÖN. In Vitro Cytotoxicity and Oxidative Stress Evaluation of Valerian (Valeriana officinalis) Methanolic Extract in Hepg2 and Caco2 Cells. Turk J Pharm Sci. 2021;18(5):604‒608.
Valerian. In: Drugs and Lactation Database (LactMed). Bethesda (MD): National Library of Medicine (US); May 17, 2021.
Hepsomali P, Groeger JA, Nishihira J, Scholey A. Effects of Oral Gamma-Aminobutyric Acid (GABA) Administration on Stress and Sleep in Humans: A Systematic Review. Front Neurosci. 2020;14:923.
Das G, Shin HS, Tundis R, et al. Plant Species of Sub-Family Valerianaceae-A Review on Its Effect on the Central Nervous System. Plants (Basel). 2021;10(5):846.
Chadwick M, Trewin H, Gawthrop F, Wagstaff C. Sesquiterpenoids lactones: benefits to plants and people. Int J Mol Sci. 2013;14(6):12780‒12805.
Panche AN, Diwan AD, Chandra SR. Flavonoids: an overview. J Nutr Sci. 2016;5:e47.
Heinrich M, Mah J, Amirkia V. Alkaloids Used as Medicines: Structural Phytochemistry Meets Biodiversity-An Update and Forward Look. Molecules. 2021;26(7):1836.
Kushiro T, Ebizuka Y. 1.18 - Triterpenes. Comprehensive Natural Products II. Elsevier; 2010: 673‒708.
Zielińska-Błajet M, Feder-Kubis J. Monoterpenes and Their Derivatives-Recent Development in Biological and Medical Applications. Int J Mol Sci. 2020;21(19):7078.
Savage K, Firth J, Stough C, Sarris J. GABA-modulating phytomedicines for anxiety: A systematic review of preclinical and clinical evidence. Phytother Res. 2018;32(1):3‒18.
Jewett BE, Sharma S. Physiology, GABA. StatPearls. Treasure Island (FL): StatPearls Publishing; 2021:July 26.
Tarkowski ŁP, Signorelli S, Höfte M. γ-Aminobutyric acid and related amino acids in plant immune responses: Emerging mechanisms of action. Plant Cell Environ. 2020;43(5):1103‒1116.
Pineau S, Legros C, Mattei C. The Medical use of Lemon Balm (Melissa officinalis) and Valerian (Valeriana officinalis) as Natural Sedatives: Insight into their Interactions with GABA Transmission. Int J Clin Pharmacol Pharmacother. 2016;1:112.
Orhan IE. A Review Focused on Molecular Mechanisms of Anxiolytic Effect of Valerina officinalis L. Connection with Its Phytochemistry through in vitro/in vivo Studies. Curr Pharm Des. 2021;27(28):3084‒3090.
Murray MT, Pizzorno J. Valeriana officinalis (Valerian), Textbook of Natural Medicine (Fifth Edition). St. Louis, Missouri: Elsevier; 2021:902-905.
Patočka J, Jákl J. Biomedically relevant chemical constituents of Valeriana officinalis. Journal of Applied Biomedicine. 2010;8:11‒18.
Cho S, Shimizu M. Natural Sleep Aids and Polyphenols as Treatments for Insomnia. Academic Press, Elsevier; 2015:141‒151.
Chadwick M, Trewin H, Gawthrop F, Wagstaff C. Sesquiterpenoids lactones: benefits to plants and people. Int J Mol Sci. 2013;14(6):12780‒12805.
Chen HW, Wei BJ, He XH, Liu Y, Wang J. Chemical Components and Cardiovascular Activities of Valeriana spp. Evid Based Complement Alternat Med. 2015;2015:947619.
Murphy K, Kubin ZJ, Shepherd JN, Ettinger RH. Valeriana officinalis root extracts have potent anxiolytic effects in laboratory rats. Phytomedicine. 2010;17(8-9):674‒678.
Mottaghipisheh J, Taghrir H, Boveiri Dehsheikh A, et al. Linarin, a Glycosylated Flavonoid, with Potential Therapeutic Attributes: A Comprehensive Review. Pharmaceuticals (Basel). 2021;14(11):1104.
Li J, Hao L, Wu J, Zhang J, Su J. Linarin promotes osteogenic differentiation by activating the BMP-2/RUNX2 pathway via protein kinase A signaling. Int J Mol Med. 2016;37(4):901‒910.
Lobo V, Patil A, Phatak A, Chandra N. Free radicals, antioxidants and functional foods: Impact on human health. Pharmacogn Rev. 2010;4(8):118‒126.
Morin CM, Beaulieu-Bonneau S, Cheung JMY. Treatment of Insomnia. Handbook of Sleep Disorders in Medical Conditions. Academic Press, Elsevier; 2019:27‒50.
Ríos JL. Effects of triterpenes on the immune system. J Ethnopharmacol. 2010;128(1):1‒14.
Seo DY, Lee SR, Heo JW, et al. Ursolic acid in health and disease. Korean J Physiol Pharmacol. 2018;22(3):235‒248.
Quintans JSS, Shanmugam S, Heimfarth L, et al. Monoterpenes modulating cytokines - A review. Food Chem Toxicol. 2019;123:233‒257.
Yang L, Liu J, Li Y, Qi G. Bornyl acetate suppresses ox-LDL-induced attachment of THP-1 monocytes to endothelial cells. Biomed Pharmacother. 2018;103:234‒239.
Volcho KP, Anikeev VI. Environmentally Benign Transformations of Monoterpenes and Monoterpenoids in Supercritical Fluids. Elsevier; 2014:69‒87.
Amaral de Brito AP, Galvão de Melo IMDS, El-Bachá RS, Guedes RCA. Valeriana officinalis Counteracts Rotenone Effects on Spreading Depression in the Rat Brain in vivo and Protects Against Rotenone Cytotoxicity Toward Rat Glioma C6 Cells in vitro. Front Neurosci. 2020;14:759.
Shi F, Li Y, Han R, et al. Valerian and valeric acid inhibit growth of breast cancer cells possibly by mediating epigenetic modifications. Sci Rep. 2021;11(1):2519.
Hellum BH, Nilsen OG. The in vitro inhibitory potential of trade herbal products on human CYP2D6-mediated metabolism and the influence of ethanol. Basic Clin Pharmacol Toxicol. 2007;101(5):350‒358.
Hellum BH, Hu Z, Nilsen OG. The induction of CYP1A2, CYP2D6 and CYP3A4 by six trade herbal products in cultured primary human hepatocytes. Basic Clin Pharmacol Toxicol. 2007;100(1):23‒30.
Hellum BH, Hu Z, Nilsen OG. Trade herbal products and induction of CYP2C19 and CYP2E1 in cultured human hepatocytes. Basic Clin Pharmacol Toxicol. 2009;105(1):58‒63.
Lefebvre T, Foster BC, Drouin CE, Krantis A, Livesey JF, Jordan SA. In vitro activity of commercial valerian root extracts against human cytochrome P450 3A4. J Pharm Pharm Sci. 2004;7(2):265‒273.
Sudati JH, Vieira FA, Pavin SS, et al. Valeriana officinalis attenuates the rotenone-induced toxicity in Drosophila melanogaster. Neurotoxicology. 2013;37:118‒126.
Bogacz A, Mrozikiewicz PM, Karasiewicz M, et al. The influence of standardized Valeriana officinalis extract on the CYP3A1 gene expression by nuclear receptors in in vivo model. Biomed Res Int. 2014;2014:819093.
Benke D, Barberis A, Kopp S, et al. GABA A receptors as in vivo substrate for the anxiolytic action of valerenic acid, a major constituent of valerian root extracts. Neuropharmacology. 2009;56(1):174‒181.
Torres-Hernández BA, Colón LR, Rosa-Falero C, et al. Reversal of pentylenetetrazole-altered swimming and neural activity-regulated gene expression in zebrafish larvae by valproic acid and valerian extract. Psychopharmacology (Berl). 2016;233(13):2533‒2547.
Dimpfel W. Pharmacological classification of herbal extracts by means of comparison to spectral EEG signatures induced by synthetic drugs in the freely moving rat. J Ethnopharmacol. 2013;149(2):583‒589.
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