Clinical application of advanced neuroimaging techniques – Magnetic Resonance Spectroscopy

Authors

  • Wiesław Guz Center for Innovative Research in Medical and Natural Sciences, Faculty of Medicine, University of Rzeszow, Rzeszow, Poland; Department of Elektroradiology, Faculty of Medicine, University of Rzeszow, Rzeszow, Poland https://orcid.org/0000-0002-1309-5374
  • Zuzanna Bober Center for Innovative Research in Medical and Natural Sciences, Faculty of Medicine, University of Rzeszow, Rzeszow, Poland https://orcid.org/0000-0002-7035-0677
  • Łukasz Ożóg Department of Biophysics, Faculty of Mathematics and Natural Sciences, University of Rzeszow, Rzeszow, Poland https://orcid.org/0000-0003-4562-1639
  • Adrian Truszkiewicz Center for Innovative Research in Medical and Natural Sciences, Faculty of Medicine, University of Rzeszow, Rzeszow, Poland https://orcid.org/0000-0002-5762-0492
  • Aneta Przypek Department of Elektroradiology, Faculty of Medicine, University of Rzeszow, Rzeszow, Poland
  • David Aebisher Department of Human Immunology, Faculty of Medicine, University of Rzeszow, Rzeszow, Poland https://orcid.org/0000-0002-2661-6570
  • Dorota Bartusik-Aebisher Department of Experimental and Clinical Pharmacology, Faculty of Medicine, University of Rzeszow, Rzeszow, Poland https://orcid.org/0000-0002-5557-5464
  • Andrzej Urbanik Department of Radiology, Collegium Medicum, Jagiellonian University, Krakow, Poland

DOI:

https://doi.org/10.15584/ejcem.2017.2.6

Keywords:

spectroscopy, MR, SVS, CSI

Abstract

Continuous scientific research and the increasing saturation of the medical market in Poland implements the possibilities of using advanced MR techniques including MRS in everyday practice. This method, which has so far been used primarily for research purposes, can bring measurable benefits to patients not only in terms of clarifying diagnosis and narrowing differential diagnosis, but also monitoring the course of various diseases and their treatment. Here we present the basic principles of performing and interpreting spectroscopic spectra and possible clinical applications and development prospects of MRS. The literature reviewed both Polish and foreign articles both historically and in the past 10 years. The paper presents methodological issues related to the proper performance of magnetic resonance spectroscopy (MRS) and spectral composition and the role of major metabolites, as well as current clinical applications and directions of MRS development.

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References

Bertoldo D, Watcharakorn A, Castillo M. Brain proton magnetic resonance spectroscopy. Introduction and overview. Neuroimag Clin N Am. 2013;23:359-380.

Jansen JFA, Backes WH, Nicolay K, Kooi ME. 1H MR spectroscopy of the brain : absolute quantification of metabolites. Radiology. 2006;240:318-332.

Posse S, Otazo R, Dager SR, Alger J. MR spectroscopis imaging : principles and recent advances. J Magn Reson Imaging. 2013;37:1301-1325.

Moonen CT, von Kienlinvan M, van Zijl PC, et al. Comparison of single-shot localization methods (STEAM and PRESS) for in vivo proton NMR spectroscopy. NMR Biomed. 1989;2:201-207.

Maudsley AA, Darkazanli A, Alger JR, et al. Comprehensive processing, display and analysis for in vivo MR spectroscopic imaging. NMR Biomed. 2006;19:492-503.

Klose U. Measurement sequences for single proton MR scpectroscopy. Eur J Radiol. 2008;67: 194-201.

Inverse problems. http://lcmodel.ca. Updated Novemver 18, 2016.

Sobiecka B, Urbanik A. The role of choline (Cho) in the diagnostics and differentiation of brain tumours with H MRS technique. Pol J Radiol. 2009;74:7.

Oz G, Alger R, Barker PB, et al. Clinical proton MR spectroscopy in central nervous system disorders. Radiology. 2014;270:658-679.

Herminghaus S, Dierks T, Pilatus U, et al. Determination of histopathological tumor grade in neuroepithelial brain tumors by using spectral pattern analysis of in vivo spectroscopic data. Journal of Neurosurgery. 2003;1:74-81.

Julià-Sapé M, Griffiths JR, Tate RA. Classification of brain tumours from MR spectra: the INTERPRET collaboration and its outcomes. NMR in Biomedicine. 2015(28):12,1772-1787.

Jaskólski DJ, Fortuniak J, Majos A et al. Magnetic resonance spectroscopy in intracranial tumours of glial origin. Neurol Neurochir Pol. 2013;47(5):438-449.

Jaskólski DJ, Fortuniak J, Stefańczyk L, Majos A, et al. Differential diagnosis of intracranial meningiomas based on magnetic resonance spectroscopy. Neurol Neurochir Pol. 2013;47(3):247-255.

An academic search engine for scientific articles site. https://pdfs.semanticscholar.org. Updated February 20, 2016.

Magierski R, Sobów T, Kłoszewska I. Spektroskopia MR w chorobach zwyrodnieniowych ośrodkowego układu nerwowego. Postępy Psychiatrii i Neurologii. 2005;14(2):155-163.

Urbanik A. Diagnostyka otępienia przy pomocy protonowej spektroskopii MR. Przegl Lek. 2010;67:237.

Szafirska M, Urbanik A, Róg T. Zmiany metaboliczne w obrębie blaszek u chorych na stwardnienie rozsiane - ocena w technice protonowej spektroskopii MR (1HMRS). Prz Lek. 2013;70(5):328-334.

Szafirska M, Urbanik A. Rola rezonansu magnetycznego w diagnostyce stwardnienia rozsianego. Ogólnopol Prz Med. 2012;3:48-53.

Podsiadło L, Urbanik A, Garlicki A, et al. 1H MRS application in the evaluation of CNS in the patents with AIDS. Pol J Radiol. 2003;68(3):5-9.

Michalska J, Kociemba W, Steinborn B, et al. Rola spektroskopii rezonansu magnetycznego w padaczce. Neur Dziecięca, 2008;34:61-64.

Silverstone PH, McGrath BM, Kim H. Bipolar disorder and myo-inositol: a review of the magnetic resonance spectroscopy findings. Bipolar Disord. 2005;7(1):1-10.

Renshow PF, Lafer B, Babb SM, et al. Basal ganglia choline levels in depression and response due to fluoxetine treatment: in vivo proton magnetic resonance spectroscopy study. Biol Psychiatry. 1997;41(8):837-43.

Rachel W, Siwek M, Dudek D, et al. Protonowa spektroskopia rezonansu magnetycznego w zaburzeniach afektywnych. Neuropsychiatr Neuropsychol. 2008;3:29.

Herman-Sucharska I, Werewka-Maczuga A, Urbanik A, et al. Ocena przydatności protonowej spektroskopii MR w diagnostyce i monitorowaniu leczenia choroby afektywnej jednobiegunowej. Przegl Lek. 2010;67:4.

Karcz P, Urbanik A. Spektroskopia protonowa mięśni podudzia przed i po wysiłku fizycznym. Przegl Lek. 2013;70(5):286-92.

Zaleska T, Walecki J, Michalak M, Michalak E. Spektroskopia magnetycznego rezonansu w kardiologii. Medical Science Review- Diagnostyka Obrazowa. 2002;1:20-24.

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Published

2017-06-30

How to Cite

Guz, W., Bober, Z., Ożóg, Łukasz, Truszkiewicz, A., Przypek, A., Aebisher, D., Bartusik-Aebisher, D., & Urbanik, A. (2017). Clinical application of advanced neuroimaging techniques – Magnetic Resonance Spectroscopy. European Journal of Clinical and Experimental Medicine, 15(2), 133–140. https://doi.org/10.15584/ejcem.2017.2.6

Issue

Vol. 15 No. 2 (2017)

Section

REVIEW PAPERS

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