Synthetic evaluation of structural brain changes in magnetic resonance imaging (MRI) with diagnosis function in persons with Down’s syndrome (DS).
Keywords:
Down syndrome, MRI, brain morphologyAbstract
In Down’s syndrome brain has abnormal morphology at all structural levels. The aim of investigations was an estimation of morphological picture brain using magnetic resonance imaging (MRI) at children and youth with DS untreated and treated according to Wrocław’s Model of Rehabilitation (WMR) in reference to homologous control group of healthy children. Investigation was carry out at 31 persons with DS in age from 4 to 28 years being under care of Children’s Develop Disturbances Outpatient Clinic in Medical Academy in Wrocław. Children with DS in view of age of beginning treatments and model of therapy were divided onto 3 groups: first group - was treated from birth according to WMR; in second group children began treatment among 2 and 8 year of life and they used different methods of treatment (so-called complex stimulation of development - CSD), meanwhile group third- not improved, was observed from 8 year of life. In obtained pictures MR, select morphological parameters were measured, which they serve to objective estimation of reduction of the brain tissue. These features allowed to construct a mathematical model of quantitative analysis, called diagnostic function ZDMPB which describes degree of morphological pathology of brain (DMPB). Statistical verification confirmed significance 253 of difference average value of population of function DMPB, qualifying degree of morphological pathology of brain among group of children with DS and healthy children. Also smaller average value DMPB of population in subgroups of children with DS systematically improved were shown, what testifies at about smaller structural deficits of brain this children and positive influence of early neurostimulation.
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